Clinical trials: Liver Transplants
Brain Damage, Postoperative Cognitive Dysfunction
Liver Transplant Does it Affect the Brain
Neuronal damage caused by neuroinflammation in patients undergoing major surgery is the most determinant factor of postoperative cognitive disfunction (POCD).
- Conditions
- Brain Damage, Postoperative Cognitive Dysfunction, Neuron Specific Enolase, Glial Fibrillary Acidic Protein
- Trial name
- NCT04368052
- Testing
- Mini Mental Test (MMT), S-100 beta, Neuron specific enolase and Glial fibrillary acidic protein
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Ege University
Liver Cirrhosis
Effect of Saccharomyces Boulardii in Patients in the Waiting List for Liver Transplant
The purpose of this study is to evaluate the effect of Saccharomyces boulardii in patients in the waiting list for liver transplant.
- Trial name
- NCT01762748
- Testing
- Saccharomyces boulardii
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Liver Transplantation, Living Donor
Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors
Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia…
- Conditions
- Liver Transplantation, Living Donor, Postoperative Pain
- Trial name
- NCT07233096
- Testing
- Rectus Intercostal Plane Block, Control (No Block)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
Cytomegalovirus, Organ Transplant
Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)
This study is being done to find out if administering CytoGam® after the end of standardly prescribed preventive antiviral treatment can help transplant recipients with a high risk for developing late CMV disease after a liver…
- Conditions
- Cytomegalovirus, Organ Transplant, Kidney Transplant; Complications, Liver Transplant Complications
- Trial name
- SHIELD (NCT06958796)
- Testing
- Cytomegalovirus Immune Globulin Intravenous (Human) monthly for three months
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Camille N. Kotton, MD
Hepatocellular Carcinoma
Multicenter RCT of ADV-TK Gene Therapy Improving the Outcome of Liver Transplantation for Advanced HCC
Compare the effect of liver transplantation (LT) plus ADV-TK gene therapy versus LT only in advanced primary hepatocellular carcinoma.
- Trial name
- NCT03313596
- Testing
- ADV-Tk, LT
- Where
- 11 sites in China
- Volunteers
- 180 people
- Sponsor
- Huazhong University of Science and Technology
Osteoporosis, Liver Transplantation
Osteoporosis in Children and Adults Following Liver Transplantation
This pilot project aims to 1) estimate the prevalence of osteoporosis in adults having undergone liver transplantation in childhood, and 2) identify risk factors for osteoporosis in this group. We aim to study 40 individuals.
- Trial name
- NCT00008788
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Research Resources (NCRR)
Renal Insufficiency
Safety Use of ATeGe in Liver Transplant Recipients With Pre-transplant Renal Dysfunction
Renal dysfunction in the context of liver transplantation is a major issue, with difficult patients' management and determining a worsened prognosis.
- Trial name
- ATG_HVH (NCT01453218)
- Testing
- ATeGe-Fresenius
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Vall d'Hebron
Liver Transplantation
Association of Genetic Polymorphism and Acute Kidney Injury After Liver Transplantation
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
- Trial name
- NCT02489474
- Where
- South Korea
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hepatocellular Carcinoma (HCC), Liver Transplantation
Validation of the TRAIN-AI for the Risk of HCC Recurrence After Liver Transplantation
Liver transplantation (LT) is the best treatment option for patients with early stages of hepatocellular carcinoma (HCC).1 However, the use of LT depends on maintaining a balance between the risk of post-transplant recurrence or…
- Conditions
- Hepatocellular Carcinoma (HCC), Liver Transplantation, Deep Learning Model
- Trial name
- TRAIN-AI (NCT06799468)
- Testing
- liver transplantation
- Volunteers
- 1,769 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Liver Transplant
Biliary Anastomosis in Living Donor Liver Transplant With Amniotic Tissue
The goal of this single armed, non-randomized, pilot study is to demonstrate that placental tissue grafts are safe in living donor liver transplant and assess their impact on biliary outcomes in adults.
- Trial name
- NCT07102550
- Testing
- MiMedx AmnioFix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Jaekeun Kim
Biliary Strictures Post Liver Transplantation
Trial Comparing Kaffes Stent With Plastic Prosthesis in the Treatment of Anastomotic Biliary Strictures Post Orthotopic Liver Transplantation
Biliary anastomotic strictures (post liver transplantation) occur in 15-20 % of the cases. Biliary stenting using plastic prosthesis during a period of 1 year is the treatment of choice.
- Trial name
- NCT01339078
- Testing
- Plastic stenting, Kaffes stenting
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Opioid Use, Auriculotherapy
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear.
- Conditions
- Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain
- Trial name
- NCT05506878
- Testing
- NSS-2 BRIDGE
- Where
- 4 sites in United States
- Volunteers
- 286 people
- Sponsor
- Jacques E. Chelly
Single Transplant, 5 Years of Follow-up After Transplant, in Which an Attempt Was Made to Suspend IS
De Novo Metabolic Syndrome in Liver Transplant Patients After Immunosuppression Withdrawal
Evaluate de novo onset of metabolic syndrome, NAFLD and NASH in liver transplant recipients who have discontinued immunosuppressive therapy ("tolerant") and in those taking immunosuppressive therapy ("non-tolerant").
- Trial name
- NCT05808192
- Testing
- Immunosuppressive
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Rome Tor Vergata
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Liver Transplant; Complications, Vitamin D Deficiency
Relationship Between Serum Vitamin D and Outcomes of Liver Transplantation in Cirrhotic Patients Undergoing Liver Transplantation and Effects of Vitamin D Supplementation in Post-transplant Period
The study population is patients with liver cirrhosis undergoing liver transplantation; In this study, the sample will be selected from cirrhosis patients undergoing liver transplantation in Taleghani (Tehran), Imam Khomeini…
- Trial name
- NCT05568836
- Testing
- vitamin D supplementation, control
- Volunteers
- 42 people
- Sponsor
- National Nutrition and Food Technology Institute
Hepatitis C Virus Infection, Liver Transplantation
Effect of Immunosuppression Drug Weaning on Hepatitis C Virus (HCV)-Induced Liver Damage After Liver Transplantation
Viral infections can profoundly influence alloimmune responses and hamper allograft tolerance induction. Persistent hepatitis C virus (HCV) infection occurs in 50% of liver and 20% of kidney transplant recipients, but the impact…
- Trial name
- NCT00668369
- Testing
- Gradual immunosuppression drug withdrawal.
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Hospital Clinic of Barcelona
HCC
Sorafenib Combined With Arsenical in Treating Patients With Recurrent HCC After Liver Transplantation
To analyze the safety, efficacy and pharmacokinetic characteristics of sorafenib combined with compound huangdai tablets in patients with recurrent hepatocellular carcinoma after liver transplantation
- Trial name
- HCC (NCT04232722)
- Testing
- Arsenicals
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Zhejiang University
Postoperative Residual Curarization, Liver Transplantation
Sugammadex/Neostigmine and Liver Transplantation
Cirrhotic patients undergoing liver transplantation are at very high risk of post operative complication such as post-operative residual curarization.
- Trial name
- NCT02697929
- Testing
- sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Immunosuppression
Conversion of CellCept to Myfortic: A Prospective Study in Liver Transplant Recipients
The objective of this study is to determine the tolerability and safety of Myfortic in liver transplant patients. Patients receiving CellCept who have GI side effects will have CellCept discontinued and changed to Myfortic…
- Trial name
- NCT00336895
- Testing
- Myfortic
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pittsburgh
Liver Transplant; Complications
Perioperative Hemostasis Management in Liver Transplantation
Liver transplantation (LT) is a surgery with risk of bleeding. Several risk factors have been identified: complex dissection, portal hypertension, history of ascites fluid infections, history of surgical procedures, pre-existing…
- Trial name
- HEMOTRANSPLANT (NCT06257407)
- Where
- 16 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
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