Clinical trials: Liver Tumour
Pancreatic Adenocarcinoma Metastatic, Liver Metastasis
NH002-mediated Sonoporation With Chemotherapy in Advanced Pancreatic Cancer
This is a phase I study that will enroll patients with pancreatic cancer and liver metastasis who have failed prior gemcitabine-based chemotherapy.
- Trial name
- NCT07314385
- Testing
- nanoliposomal irinotecan+5-FU+leucovorin, NH002 (Perflutren Lipid Microspheres) Injectable Suspension, Aco Apache Ultrasound
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- National Taiwan University Hospital
Hepatocellular Carcinoma (HCC), Second Line Treatment
A Phase II, Single-Arm, Prospective Trial on the Efficacy and Safety of QL1706 Combination Regimen as Second-Line Therapy for Targeted-Immunotherapy-Resistant Hepatocellular Carcinoma
The goal of this prospective Phase II clinical trial is to evaluate the efficacy and safety of QL1706-based combination therapy in patients with hepatocellular carcinoma (HCC) who have failed prior targeted-immunotherapy (e.g.…
- Trial name
- DRIVE-II (NCT07138885)
- Testing
- HAI-FOLFOX + bevacizumab + QL1706, TACE + bevacizumab + TAS-102 + QL1706
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma
Hepatocellular Carcinoma Using Stereotactic Body Radiotherapy
Respiratory-gated, volumetric-modulated arc therapy will be used for the clinical development of high dose rate Stereotactic Body Radiotherapy (SBRT) in inoperable hepatocellular carcinoma (HCC).
- Trial name
- NCT01850316
- Testing
- Stereotactic Ablative Radiotherapy
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Unresectable Hepatocellular Carcinoma
Long-Term Survival With Lenvatinib-Based Therapy in Unresectable Liver Cancer
This study reviewed real-world outcomes of patients with unresectable hepatocellular carcinoma who received lenvatinib-based treatment.
- Trial name
- NCT07298538
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hepatocellular Carcinoma
Yang Yin Fu Zheng Jie Du Therapy in HBV Related Hepatocellular Carcinoma Induced Anemia (YYFZJDTIHBVRHCIA)
Clinical research of Yang Yin Fu Zheng Jie Du therapy in HBV related hepatocellular carcinoma induced anemia. The purpose of this study is to observe the efficacy of routine medical care combined with Yang Yin Fu Zheng Jie Du…
- Trial name
- NCT05088733
- Testing
- Yang Yin Fu Zheng Jie Du therapy, Routine medical care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Ditan Hospital
Hepatocellular Carcinoma, Cirrhosis
Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant
Immunotherapy can safely downstage patients and achieve durable systemic disease control to improve clinical outcomes in HCC patients undergoing liver transplant.
- Conditions
- Hepatocellular Carcinoma, Cirrhosis, Portal Hypertension
- Trial name
- NCT05027425
- Testing
- Durvalumab, Tremelimumab, Liver Transplant
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati
Hepatocellular Carcinoma
Phase II Study of Fruquintinib Combined With Sintilimab and TACE for Inoperable Primary Hepatocellular Carcinoma
The goal of this prospective, interventional clinical trial is to evaluation of fruquintinib in combination with sintulimab and TACE for inoperable primary hepatocellular carcinoma for progression-free survival (PFS).
- Trial name
- NCT05971199
- Testing
- Fruquintinib, Sintilimab, Transcatheter arterial chemoembolization（TACE）
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Zhejiang Cancer Hospital
Oncology, Interventional Radiology
Clinical Evaluation of an Augmented Reality Intraprocedural Needle Guidance Platform for Soft Tissue Biopsy
This clinical feasibility evaluation is intended to further characterize and quantify the potential benefits of the FDA-cleared XR90 Augmented Reality (AR )imaging and guidance platform utilization in percutaneous soft tissue…
- Conditions
- Oncology, Interventional Radiology, Liver Carcinoma, Renal Carcinoma
- Trial name
- NCT07046832
- Testing
- Augmented Reality Guided Biopsy, Ultrasound Guided Biopsy
- Where
- 3 sites in United States
- Volunteers
- 104 people
- Sponsor
- MediView XR, Inc.
Stage I Adult Liver Cancer, Stage I Colorectal Cancer
Electronic Monitoring Device of Patient-Reported Outcomes and Function in Improving Patient-Centered Care in Patients With Gastrointestinal Cancer Undergoing Surgery
This pilot clinical trial studies an electronic monitoring device of patient-reported outcomes (PROs) and function in improving patient-centered care in patients with gastrointestinal cancer undergoing surgery.
- Conditions
- Stage I Adult Liver Cancer, Stage I Colorectal Cancer, Stage IA Gastric Cancer, Stage IA Pancreatic Cancer
- Trial name
- NCT02511821
- Testing
- Computer-Assisted Intervention, Vivofit watch, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Hepatocellular Carcinoma (HCC), Liver Transplantation
Validation of the TRAIN-AI for the Risk of HCC Recurrence After Liver Transplantation
Liver transplantation (LT) is the best treatment option for patients with early stages of hepatocellular carcinoma (HCC).1 However, the use of LT depends on maintaining a balance between the risk of post-transplant recurrence or…
- Conditions
- Hepatocellular Carcinoma (HCC), Liver Transplantation, Deep Learning Model
- Trial name
- TRAIN-AI (NCT06799468)
- Testing
- liver transplantation
- Volunteers
- 1,769 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Colorectal Cancer
Short-term Effects of LASI Surgery Versus Conventional Laparotomy for Colorectal Liver Metastasis
Surgical resection is still recommended as the optional treatment for colorectal liver metastasis (CLM) patients. There are two main concerns for resectable colorectal liver metastasis which remain controversial: surgical time…
- Trial name
- NCT02350166
- Testing
- laparoscopic surgery
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Hepatocellular Carcinoma
Balloon Assisted Transarterial Therapy for Hepatocellular Carcinoma
To prove the treatment concept of the use of balloon assistance in transarterial therapy for HCC.
- Trial name
- NCT04780802
- Testing
- The balloon catheter is placed at the various arterial feeders of the tumor
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Hepatocellular Carcinoma, Renal Cell Carcinoma
Study of ACC-1898 in Adult Participants With Advanced Solid Tumors
This is a research study of an experimental drug called ACC-1898. ACC-1898 is an oral tyrosine kinase inhibitor (TKI) that blocks several proteins kinases which may help cancer cells grow and spread.
- Conditions
- Hepatocellular Carcinoma, Renal Cell Carcinoma, Thyroid Carcinoma, Medullary, Thyroid Carcinoma Primary Differentiated
- Trial name
- NCT07252661
- Testing
- ACC-1898
- Volunteers
- 40 people
- Sponsor
- AccSalus Biosciences, Inc.
Liver Metastases
Comparison Between LDCT With DL Recontruction and Standard Dose CT
This prospective study aims to perform intra-individual comparison of the image quality between low dose liver CT with deep learning reconstruction and standard dose liver CT with iterative reconstruction in patients with liver…
- Trial name
- NCT05324046
- Testing
- contrast-enhanced abdomen CT
- Where
- 2 sites in South Korea
- Volunteers
- 134 people
- Sponsor
- Seoul National University Hospital
HepatoCellular Carcinoma
Study of Y90-Radioembolization With Nivolumab in Asians With Hepatocellular Carcinoma
The purpose of this study is to evaluate the effect of liver-localised radioembolization and nivolumab on liver cancer.
- Trial name
- NCT03033446
- Testing
- Y-90 Radioembolization, Nivolumab
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National Cancer Centre, Singapore
Carcinoma, Hepatocellular
Risk of Hepatocellular Carcinoma in Patient With Liver Cirrhosis
Purpose of the study is to determine transcriptomics, metabolomics and proteomics features of liver cirrhotic tissue in patients with hepatocellular carcinoma (HCC) and to find a correlation with the risk of developing HCC and…
- Trial name
- NCT03083002
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Modena and Reggio Emilia
Hepatocellular Carcinoma, Hepatocellular Cancer
Natural History Study of Children and Adults With Fibrolamellar Hepatocellular Carcinoma
Background: Fibrolamellar Hepatocellular Carcinoma (FL-HCC) is a rare liver cancer. It usually occurs in young people who have no history of liver disease.
- Trial name
- NCT03748927
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Hepatocellular Carcinoma, Liver Metastases
Study of Palliative Radiotherapy for Symptomatic Hepatocellular Carcinoma and Liver Metastases
The purpose of this study is to see whether one dose of palliative radiation therapy directed to the liver in combination with standard BSC might help to reduce liver pain/discomfort due to cancer when compared to getting…
- Trial name
- NCT02511522
- Testing
- Best Supportive Care, Palliative Radiation Therapy
- Where
- 7 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Canadian Cancer Trials Group
Malignancies
Identifying Tissue-of-origin in Transplant Patients and Patients with Malignancies.
the investigators are developing a method for diagnosing cell death in the body using blood and urine tests. The test is based on two well-known phenomena in biology.
- Trial name
- cfDNA (NCT06703853)
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Hadassah Medical Organization
Colorectal Neoplasms
Colorectal Cancer Treated With Adjuvant Regorafenib Versus Placebo After Curative Treatment of Liver Metastases in a Randomized, Double-blind, Placebo-Controlled Phase-III STudy
To evaluate and compare the efficacy and safety of regorafenib versus placebo in subjects with colorectal cancer (CRC) after curative resection of liver metastasis and completion of all planned chemotherapy.
- Trial name
- COAST (NCT01939223)
- Testing
- Regorafenib (Stivarga, BAY73-4506)
- Where
- 121 sites in United States, Australia and 12 more
- Volunteers
- 25 people
- Sponsor
- Bayer
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