Clinical trials: Living Donor Liver Transplantation
Transplantation Infection, Liver Grafting
Bacillus Clausii in Liver Transplantation
A prospective, randomized, controlled study of the safety and efficacy of using Bacillus clausii probiotic oral preparation to decrease the incidence of infection during the first 30 days after living donor liver transplantation…
- Conditions
- Transplantation Infection, Liver Grafting, Hepatic Transplantation
- Trial name
- NCT05047406
- Testing
- Bacillus clausii Probiotic liquid
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Living Donor Liver Transplantation
Impact of Splenic Artery Ligation in LDLT for Patients With Portal Hypertension
In this study, the investigators aim to prove that performing splenic artery ligation in living donor liver transplantation for patients with portal hypertension is beneficial for early graft function postoperatively.
- Trial name
- NCT04988100
- Testing
- splenic artery ligation, No intervention
- Volunteers
- 30 people
- Sponsor
- Assiut University
Liver Transplant; Complications, Renal Injury
Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury
This study is a prospective observational study of a single cohort of the patients who will undergo a scheduled living donor liver transplantation.
- Trial name
- NCT03877133
- Testing
- Near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Liver Transplant
Outflow Reconstruction in Right Lobe Living Donor Liver Transplantation
Modified Right Lobe Graft(MRLG) is one of the most common used graft in liver transplantation .Anterior sector of allograft in MRLG usually congested to decrease this congestion tributaries of middle hepatic vein should be…
- Trial name
- NCT03666689
- Testing
- surgical technique
- Volunteers
- 50 people
- Sponsor
- Assiut University
Donor Hepatectomy, Serum Lactate
Effect of Preoperative Carbohydrate Loading on Serum Lactate Levels in Patients Undergoing Donor Hepatectomy
This randomized controlled trial investigated whether preoperative carbohydrate loading reduces perioperative serum lactate levels in patients undergoing donor hepatectomy.
- Conditions
- Donor Hepatectomy, Serum Lactate, Preoperative Carbohydrate Loading
- Trial name
- NCT07723391
- Testing
- Preoperative Carbohydrate Loading
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shifa International Hospital
Liver Transplant, Complications
Doppler Ultrasonography in Assessment of Graft Hemodynamics After Living-Donor Liver Transplantation
Graft ischemia after liver transplantation is associated with a high incidence of morbidity and mortality . The overall incidence of vascular complications in adults varies widely among transplant centers worldwide, but remains…
- Trial name
- NCT03893773
- Testing
- doppler ultrasonagraphy
- Volunteers
- 50 people
- Sponsor
- ZRMohamed
Living Donor Liver Transplantation
Delayed Infusion of DCreg in Living Donor Liver Transplantation
Phase I/II, single center, prospective, open-label, non-controlled, non-randomized, interventional, cohort study in which low risk living donor liver transplant (LDLT) recipients who are between 1 and 3 years after…
- Trial name
- NCT04208919
- Testing
- Donor-derived DCreg
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Angus W. Thomson PhD DSc
Cirrhosis, Liver
Graft Inflow Modulation for Portal Hyper-perfusion in Live Donor Liver Transplantation
In this study, the investigators aim to prove that performing graft inflow modulation (GIM) in liver with portal hyper-perfusion is beneficial for early graft function postoperatively.
- Trial name
- NCT04252794
- Testing
- Splenic artery ligation, No intervention
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Tissue Donors, Liver Transplantation
The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy
Liver transplantation is the gold standard treatment for patients with end-stage liver disease. Despite its outstanding success, liver transplantation still entails certain complications including ischemia-reperfusion injury.
- Conditions
- Tissue Donors, Liver Transplantation, Ischemia Reperfusion Injury
- Trial name
- NCT03386435
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Massive Ascites
Impact Of Timing Of Drainage Of Massive Ascites On Operative And Post-Operative Course In Living-Donor Liver Transplant Recipients. A Prospective Randomized Controlled Trial.
Massive ascites is usually controlled over several weeks pre-operatively in liver transplant recipients with the risk of encephalopathy and peritonitis.
- Trial name
- AscitesLDLT (NCT02867293)
- Testing
- ultrasound guided ascitic fluid drainage, operative drainage of ascites through small skin incision after induction of anesthesia, ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Living Donor Liver Transplantation, Liver Transplantation
Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma
This study is supposed to make liver transplantation available for treatment in well selected patients suffering from non-resectable intrahepatic cholangiocarcinoma.
- Conditions
- Living Donor Liver Transplantation, Liver Transplantation, Neoadjuvant Therapy
- Trial name
- LIVINCA (NCT06539377)
- Testing
- Living donor liver transplantation
- Volunteers
- 6 people
- Sponsor
- Jena University Hospital
Chronic Liver Disease
Effect of Perioperative Oral Rifaximin on Early Graft Dysfunction in Adult Living Donor Liver Transplant
Liver transplantation has been a lifesaving treatment for individuals with end stage liver disease and acute liver failure. However, initial poor function of a liver allograft after liver transplantation, termed early graft…
- Trial name
- NCT06743464
- Testing
- Rifaximin 550 MG, SOC
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Liver Disease and Cirrhosis
Influence of Donor and Recipient Genetic Polymorphisms on Graft Steatosis After Liver Transplant
MASH (Metabolic Dysfunction-associated Steatohepatitis) is among the most common indications for liver transplantation.The metabolic syndrome persists after liver transplant and is often further exacerbated among MAFLD patients…
- Trial name
- NCT07685353
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Liver Transplantation
Duct-to-duct vs Roux-en-y Hepaticojejunostomy for Biliary Reconstruction in Adult Living Donor Liver Transplantation
The purpose of this study is to empirically determine whether one of 2 surgical techniques commonly used for bile duct reconstruction during living donor liver transplantation results in fewer biliary complications.
- Trial name
- NCT00646685
- Testing
- surgical technique: duct-to-duct biliary reconstruction, surgical technique: roux-en-y biliary reconstruction
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Hcc
Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria
The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.
- Trial name
- NCT04069416
- Testing
- living donor liver transplantation
- Volunteers
- 241 people
- Sponsor
- Ain Shams University
Liver Transplant Rejection
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients.
Our study aimed at studying the impact of gene polymorphism of NFKBIA and PTPN22 genes on rejection episodes in liver transplant Egyptian recipients. Also assess patients' factors associated with graft rejection.
- Trial name
- NCT06060808
- Testing
- gene polymorphism
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Helwan University
Living Donor Liver Transplantations With Anti-HBc (+) Grafts
Long-term Outcomes of Living Donor Liver Transplantations With Anti-HBc (+) Grafts in Pediatric Patients
The goal of this observational study is to compare in anti-HBc (+) grafts/ anti-HBc (-) grafts. The main question it aims to answer is the long-term efficacy of active vaccination and graft/patient outcomes of anti-HBc (+) grafts…
- Trial name
- NCT06290726
- Volunteers
- 204 people
- Sponsor
- Chang Gung Memorial Hospital
Liver Transplantation
Long-term Follow-up of Living Liver Donors: A Single-center Experience
Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239…
- Trial name
- NCT04814290
- Testing
- health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).
- Volunteers
- 476 people
- Sponsor
- Mansoura University