Clinical trials: Living Donor of Kidney
Kidney Transplant Failure and Rejection
Individualization of the Immunological Risk Based on Selective Biomarkers in Living-donor Renal Recipients
This is a clinical trial comparing the immunosuppressive treatment determined according to two biomarkers, donor-specific IFN-γ ELISPOT and Mismatch of HLA between donor and recipient, in patients undergoing low immunological…
- Trial name
- BIOIMMUN (NCT03465397)
- Testing
- biomarkers driven immunosuppressive therapy
- Where
- 6 sites in Spain
- Volunteers
- 164 people
- Sponsor
- ORIOL BESTARD
Kidney Failure, Surgery
Effect of Lost Wage Reimbursement to Kidney Donors on Living Donation Rates
The study is designed as a randomized controlled trial. The investigators hypothesize that kidney transplant recipient candidates whose donors are offered reimbursement of lost wages (treatment arm) will have a higher probability…
- Conditions
- Kidney Failure, Surgery, Renal Failure
- Trial name
- NCT03350269
- Testing
- Information provision
- Where
- 6 sites in United States
- Volunteers
- 1,310 people
- Sponsor
- Arbor Research Collaborative for Health
Kidney Transplantation
A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA)
The purpose of this study is to determine the optimal regimen for the use of siplizumab, a human anti-CD2 antibody, combined with donor bone marrow cells and non-myeloablative conditioning, for tolerance induction in living donor…
- Trial name
- NCT04803006
- Testing
- TCD601
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- ITB-Med LLC
Kidney Transplantation
Evaluation of 2 Techniques of Apheresis to Desensitize ABO Incompatible Kidney Transplant Candidates
Kidney transplantation is the treatment of choice for end-stage renal disease. ABO incompatible (ABOi) living donor kidney transplantation is one of the best ways to expand the donors' pool.
- Trial name
- DADI (NCT03477656)
- Testing
- Large volume specific immunoadsorption, Double Filtration Plasmapheresis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Kidney Transplantation
Clinical Trial With Donor Modified Immune Cells in Living Donor Kidney Transplantation
In this clinical trial the investigational medicinal product MIC is to be examined for its efficacy and safety in patients with living kidney transplantation.
- Trial name
- NCT05365672
- Testing
- MIC, Standard of Care
- Where
- 8 sites in Germany
- Volunteers
- 126 people
- Sponsor
- TolerogenixX GmbH
Healthy, Living Kidney Donation
Telemedicine to Support Living Kidney Donor Candidates
The goal of this feasibility clinical trial is to learn if telemedicine can be used to provide education and evaluation and counseling for people who are considering living kidney donation.
- Trial name
- NCT07206069
- Testing
- Standard Care (in control arm), Telemedicine Shared Decision-Making
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Kidney Transplant Recipients
Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplantation
The study will compare how well transplanted kidneys work and the response of people's immune systems as tacrolimus, a calcineurin inhibitor (CNI), is withdrawn.
- Trial name
- NCT01517984
- Testing
- Tacrolimus (CNI) Withdrawal, Standard Immunosuppressive Therapy
- Where
- 11 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Transplant Donation
Information-Assisted Intervention for Potential Living Kidney Donors
This study aims to evaluate the effectiveness of an information-assisted intervention in enhancing knowledge, decision self-efficacy, and reducing decisional conflict among potential living kidney donors.
- Trial name
- NCT07243717
- Testing
- Information-Assisted Intervention
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Renal Transplantation, Uremia
Clonal Deletion on Living-Relative Donor Kidney Transplantation
The objective of this trial is to determine if clonal deletion before kidney transplantation can effectively reduce the need for post transplant immunosuppression.
- Trial name
- DAWN (NCT01408797)
- Testing
- donor specific transfusion, MMF, Bortezomib, drugs added according to the immuno condition of the recipients
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Fuzhou General Hospital
Cytomegalovirus (CMV) Infection, Kidney Transplantation
A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients
HB-101 is a bivalent recombinant vaccine against human CMV infection. This is a randomized, placebo-controlled, phase 2 study to assess the safety, reactogenicity, immunogenicity, and efficacy of HB-101 in CMV-Seronegative…
- Trial name
- NCT03629080
- Testing
- HB-101 vaccine
- Where
- 25 sites in United States, Denmark and 4 more
- Volunteers
- 83 people
- Sponsor
- Hookipa Biotech GmbH
Liver Transplant; Complications, Renal Injury
Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury
This study is a prospective observational study of a single cohort of the patients who will undergo a scheduled living donor liver transplantation.
- Trial name
- NCT03877133
- Testing
- Near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Renal Transplantation, Graft Rejection
A Study to Evaluate the Effect of Thymoglobulin and Reduced Doses of Steroids to Prevent Renal Transplant Rejection
This study involves the use of a drug called Thymoglobulin, which is approved in the US to treat kidney transplant rejection and in Canada to treat and to prevent kidney transplant rejection.
- Trial name
- NCT00089947
- Testing
- Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)]
- Where
- 19 sites in United States
- Volunteers
- 150 people
- Sponsor
- Genzyme, a Sanofi Company
Kidney Transplantation (Status Post), Preoperative Anxiety
Animated Video Versus Written Leaflet for Preoperative Kidney Transplant Education
This randomized comparative trial evaluated whether an animated educational video, added to standard verbal counselling, differs from a content-matched written information leaflet, also added to standard verbal counselling, in…
- Conditions
- Kidney Transplantation (Status Post), Preoperative Anxiety, Patient Education
- Trial name
- NCT07651384
- Testing
- Animated educational video, Written information leaflet
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Delirium After Living Donor Renal Transplantation
Effects of Dexmedetomidine on Delirium After Living Donor Renal Transplantation in Adult Patients
Delirium, an acute change in mental status, is a serious medical complication among hospitalized patients. Syndrome of delirium involves agitation, sleep disturbance, affective disorders and cognitive disruptions.
- Trial name
- NCT02509949
- Testing
- Dexmedetomidine, Saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tao Zhang
Living Kidney Donors Undergoing VAMS-nephrectomy
Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study
Hyperalgesia is known to be caused by the excitatory amino acid through NMDA receptor. GABA, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia.
- Trial name
- NCT02340455
- Testing
- Pregabalin_male, Pregabalin_female
- Where
- South Korea
- Sponsor
- Yonsei University
Transplanted Organ Rejection
A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation
A randomized controlled study to evaluate the safety, efficacy, and overall benefit of FCR001 cell therapy in de novo living donor renal transplantation.
- Trial name
- FREEDOM-1 (NCT03995901)
- Testing
- FCR001
- Where
- 18 sites in United States
- Volunteers
- 15 people
- Sponsor
- Talaris Therapeutics Inc.
Transplant Recipient (Kidney)
Clinical and Immunological Outcomes of Living and Deceased Donor Transplantation
This is a retrospective, prospective, single-centre, non-pharmacological observational study. The primary objective is to investigate the long-term prognosis of the kidney transplant function of different types of donors.
- Trial name
- TxBo2022 (NCT06759831)
- Where
- Italy
- Volunteers
- 1,293 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Kidney Injury, Liver Transplantation
Perioperative Evaluation of Terlipressin Infusion During Living Donor Liver Transplantation on Incidence of Acute Kidney
To study the impact of intra and post-operative Terlipressin infusion on the occurrence of acute kidney injury after LDLT To investigate perioperative Neutrophil Gelatinase Associated Lipocalin (NGAL) changes and study the effect…
- Conditions
- Acute Kidney Injury, Liver Transplantation, Terlipressin, NGAL
- Trial name
- Terli-NGAL (NCT02059460)
- Testing
- Terlipressin
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- National Liver Institute, Egypt
Immune Tolerance
Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation
This research study is to determine if donor blood stem cells given after living, related, HLA antigen (Ag) haplotype match or living, unrelated donor kidney transplantation.
- Trial name
- CIRM (NCT03292445)
- Testing
- Immune tolerance after kidney transplant, Donor blood stem cells and T cells
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Strober
Skin Closure of Surgical Incisions by Tissue Glue vs Suture
Tissue Glue (Cyanoacrylate) Versus Conventional Suture in Kidney Donors
By means of a prospective, randomised trial the investigators want to examine skin closure in living donors - subjected to laparoscopic, hand-assisted nephrectomy - by tissue glue (Cyanoacrylate (Liquiband)) versus conventional…
- Trial name
- TG-CYANO (NCT01521871)
- Testing
- Skin wound closure by tissue glue, Skin wound closure by conventional suture + dressing
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital