Clinical trials: Living Donors
Liver Transplantation, Portal Hypertension
Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantation
The goal of this clinical trial is to compare the effects of somatostatin and terlipressin on lowering portal pressure in patients with portal hypertension undergoing liver transplantation, and to investigate whether there are…
- Trial name
- NCT07304466
- Testing
- Somatostatin, Terlipressin
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medipol University Hospital
Patency, Hepatic Venous Congestion
Usability of Ringed Polytetrafluoroethylene Graft for Venous Vascular Reconstruction of Living Donor Liver Transplantation
Middle hepatic vein (MHV) reconstruction with an interposition vessel graft has been settled as a standard procedure for living donor liver transplantation (LDLT) using a right lobe graft.
- Trial name
- MHVLDLT (NCT01205802)
- Testing
- MHV reconstruction
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Acute Kidney Injury, Liver Diseases
Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation
Acute kidney injury (AKI) following liver transplantation (LT) is associated with increased costs, morbidity, and mortality. Dexmedetomidine has known to have anti-inflammatory effect and has been shown to ameliorate IRI in…
- Trial name
- NCT03522688
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Asan Medical Center
Pediatric Liver Transplantation
Prospective Tacrolimus Pharmacokinetics Study in Pediatric Living Donor Liver Transplantation
Our first aim is thus to investigate, retrospectively first and then prospectively, in de novo pediatric (living donor) liver recipients, the tacrolimus in vivo and in vitro metabolism and its variability with focus on…
- Trial name
- NCT02064777
- Testing
- Tacrolimus
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ACL
LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study
The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients.
- Trial name
- LivD_ACLR (NCT05395767)
- Testing
- Endoscopic Anterior Cruciate Ligament reconstruction using living donor hamstring allograft from a parent donor
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
Donor Hepatectomy
Dexmedetomedine Infusion Versus Fentanyl Infusion for Donor Anlgesia During Living Donor Hepatectomy
To compare between the analgesic effect of dexmedetomedine infusion versus Fentanyl infusion during donor hepatectomy.
- Trial name
- NCT02531529
- Testing
- dexmedetomedine, Fentanyl
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mansoura University
End-Stage Renal Disease, Chronic Kidney Diseases
Technology-enabled Social Network Intervention to Increase Live Donor Kidney Transplantation
The study is a 2-arm randomized controlled trial among patients referred for kidney transplant evaluation at a single transplant center to compare the effects of a digital-analog intervention to increase living-donor kidney…
- Conditions
- End-Stage Renal Disease, Chronic Kidney Diseases, Kidney Transplant, Living Kidney Donor
- Trial name
- KT-CONNECT (NCT07072767)
- Testing
- Digital education outreach intervention for kidney transplant access and human guide, Digital education outreach intervention for kidney transplant access only (unguided)
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- State University of New York at Buffalo
Kidney Failure, Kidney Diseases
Expanding Live Donor Kidney Transplantation Through Advocacy Training and Social Media
This pilot study will be a clinical trial to test the feasibility and effectiveness of an educational intervention and a mobile health intervention in adults with end stage renal disease (ESRD) who have not yet identified a…
- Trial name
- ENGAGE (NCT03099434)
- Testing
- Facebook App, Live Donor Champion + Facebook App
- Where
- 2 sites in United States
- Volunteers
- 775 people
- Sponsor
- Johns Hopkins University
Transplantation, Kidney, Living Donors
Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients
The aim of this study is to determine a comprehensive immune profile of transplant donors and recipients through assessment of immune cell compositions in bone marrow, and lymph nodes.
- Conditions
- Transplantation, Kidney, Living Donors, Kidney Transplant Recipients
- Trial name
- NCT01150487
- Testing
- bone marrow aspirations, lymph node collection
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Ischemia Reperfusion Injury
Purge Vs no Purge in Living Donor Liver Transplantation Recipients
The investigators tested the impact of purging the graft contents and mesenteric blood into the systemic circulation versus washing out this volume out of the circulation in living donor liver transplantation recipients.
- Trial name
- PNP (NCT02540447)
- Testing
- Purge
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Kidney Transplant Candidates
Increasing Communication About Live Donor Kidney Transplant
This study will test the efficacy of a communication intervention intended to increase and improve kidney transplant candidates' communication about live donor kidney transplantation.
- Trial name
- NCT01855438
- Testing
- Living Donor Transplant Education
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplantation
Trial of Rituximab Given Pre-Transplant to Sensitised Live Donor Kidney Recipients
About one third of prospective kidney transplant recipients have antibodies in their blood directed against the tissues of their only available kidney donor.
- Trial name
- RAPTURE (NCT00371904)
- Testing
- Rituximab, Standard Care
- Where
- 3 sites in Australia
- Volunteers
- 192 people
- Sponsor
- Hunter and New England Health
Catheter-Associated Urinary Tract Infections (CAUTIs), Kidney Transplantation
Early (Postoperative Day 3) Versus Standard (Postoperative Day 6) Urethral Catheter Removal After Living Donor Kidney Transplantation
Urinary tract infection is one of the most common complications after kidney transplantation and is associated with increased morbidity, prolonged hospitalization, and impaired graft outcomes.
- Trial name
- (EARLY-KTx) (NCT07681843)
- Testing
- Early urethral catheter removal, Standard urethral catheter removal
- Where
- Israel
- Volunteers
- 172 people
- Sponsor
- Fahim Kanani
Endstage Kidney Disease
Implementing "Explore Transplant"- A Pilot Study
Patients with End Stage Kidney Disease (ESKD) require Renal Replacement Therapy (RRT) in order to survive, be it dialysis or kidney transplantation (KT).
- Trial name
- NCT03046732
- Testing
- Implementing "Explore Transplant" Education
- Where
- 2 sites in Canada
- Volunteers
- 227 people
- Sponsor
- University Health Network, Toronto
End Stage Renal Disease and Kidney Transplantation
Communicating About Choices in Transplantation
The purpose of this study is to test the impact of a newly developed educational program on kidney transplant candidates' communication about living and deceased donor kidney transplantation.
- Trial name
- COACH (NCT01853007)
- Testing
- COACH Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Living Liver and Kidney Donors
Living Organ Donor Recovery Enhancement Program
The purpose of the study is to test if using these living donor-specific pre-transplant resources would lead to a better and faster recovery post-transplant.
- Trial name
- NCT03865264
- Testing
- Recovery Enhancement Program
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
End Stage Renal Disease, Transplantation
Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study
Kidney transplantation from living donors has been shown to carry many benefits over deceased donor transplantation. Because of benefits such as shorter waiting times and improved outcome for transplant recipients, living kidney…
- Trial name
- NCT00951977
- Where
- 3 sites in United States
- Volunteers
- 7,029 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Renal Transplant Donor of Left Kidney, Renal Transplant Donor of Right Kidney
Fractures and Bone Disease in Living Kidney Donors
This research study is being done to measure bone health in living kidney donors and compare them to non-kidney donors to learn if living kidney donors have a higher risk of bone fractures (breaks) after kidney donation.
- Trial name
- NCT04810884
- Where
- United States
- Volunteers
- 4,415 people
- Sponsor
- Mayo Clinic
Liver Transplantation
Non-Invasive Assessment of Graft Fibrosis After Living Donor Liver Transplantation
The aim of this study is to compare prospectively the ability of MRE and Transient Elastography in detection and staging of allograft fibrosis in comparison to Liver biopsy in patients who underwent Living Donor Liver…
- Trial name
- NCT03176290
- Testing
- Fibro-α score = (1.35 (numeric constant) +AFP (IU ml-1) × 0.009584 + aspartate aminotransferase (AST)/alanine aminotransferase(ALT) × 0.243 - platelet count (×109 l-1) × 0.001624).
- Volunteers
- 31 people
- Sponsor
- Ain Shams University