Clinical trials: Living Donors
ACL
LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study
The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients.
- Trial name
- LivD_ACLR (NCT05395767)
- Testing
- Endoscopic Anterior Cruciate Ligament reconstruction using living donor hamstring allograft from a parent donor
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
Kidney Transplant, End Stage Kidney Disease (ESRD)
ABO- or HLA- Incompatible LDKT Compared to Waitlist/DDKT in Elderly Patients
This retrospective multicenter cohort study evaluates the survival outcomes of elderly patients (aged ≥60 years) with end-stage kidney disease who underwent ABO- or HLA-incompatible living donor kidney transplantation compared…
- Trial name
- NCT07436338
- Where
- 2 sites in South Korea
- Volunteers
- 1,819 people
- Sponsor
- Seoul National University Hospital
Kidney Transplant Recipients
Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplantation
The study will compare how well transplanted kidneys work and the response of people's immune systems as tacrolimus, a calcineurin inhibitor (CNI), is withdrawn.
- Trial name
- NCT01517984
- Testing
- Tacrolimus (CNI) Withdrawal, Standard Immunosuppressive Therapy
- Where
- 11 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemodynamic Instability
Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation
The aim of this study is to compare the accuracy of PVI (pleth variability index)
- Trial name
- NCT01792011
- Testing
- PVI-guided fluid management
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Inonu University
Chronic Kidney Disease, End-stage Renal Disease
A Randomized Trial to Reduce the Disparity in Live Donor Kidney Transplantation
The main purpose of this study is to learn which educational method is most helpful to patients and their family members when they consider whether to pursue live donor kidney transplantation.
- Trial name
- NCT00785265
- Testing
- Group-Based (GB) Intervention, Home-Based (HB) Intervention
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Beth Israel Deaconess Medical Center
Renal Failure, End Stage
The ONE Study ATDC Trial
To collect evidence of the safety of administering autologous tolerogenic dendritic cells (ATDC) preparations to living-donor renal transplant recipients in the context of an international European Union funded consortium aimed…
- Trial name
- ONEatDC (NCT02252055)
- Testing
- ATDC_Nantes
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Nantes University Hospital
End-stage Renal Failure, Kidney Graft Rejection
Reference Group Trial for The ONE Study
To investigate the progression of the immunological response in living-donor kidney transplant recipients treated with a standard immunosuppressive regimen.
- Trial name
- NCT01656135
- Testing
- Blood drawing for immune monitoring and questionnaires
- Where
- 8 sites in United States, France and 3 more
- Volunteers
- 70 people
- Sponsor
- University of Regensburg
Kidney Failure
Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor FCRx Infusion
An open-label study to assess the safety, efficacy, and tolerance of FCRx cell therapy in adult recipients within 12 months after kidney transplantation from a living donor.
- Trial name
- NCT00497926
- Testing
- Enriched Hematopoietic Stem Cell Infusion
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Talaris Therapeutics Inc.
Renal Insufficiency
Atorvastatin in the Recipient's Kidney Graft From a Living Donor
Renal insufficiency is a priority disease in the health system, which may require renal replacement therapy based on kidney transplantation, which is considered as therapy of choice.
- Trial name
- ATORV15 (NCT02522117)
- Testing
- Atorvastatin
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Patency, Hepatic Venous Congestion
Usability of Ringed Polytetrafluoroethylene Graft for Venous Vascular Reconstruction of Living Donor Liver Transplantation
Middle hepatic vein (MHV) reconstruction with an interposition vessel graft has been settled as a standard procedure for living donor liver transplantation (LDLT) using a right lobe graft.
- Trial name
- MHVLDLT (NCT01205802)
- Testing
- MHV reconstruction
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Liver Transplant
Stented Biliary Anastomosis in Living Donor Liver Transplantation
Determination of biliary complications in stented group compared to duct to duct anastomosis without stent
- Trial name
- NCT03636321
- Testing
- living donor liver transplantation with internal biliary stent
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alaa Mstafa Hassan Sewefy
End Stage Liver Disease
Spray Diathermy Versus Harmonic Scalpel Technique for Hepatic Parenchymal Transection
Consecutive patients, who were treated for end stage liver cirrhosis by LDLT were included in this a prospective study.Patients enrolled in the study divided into two groups according to the day of surgery.
- Trial name
- LDLT (NCT02617498)
- Testing
- harmonic scalpel, spray mode diathermy
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Transplantation, Liver
PK of MMF in Cadaveric vs Living Donor Liver Transplant Recipients
The purpose of this study is to measure the amount of MMF and tacrolimus concentration in the blood at a given time. Currently MMF is ordered as a set dose and tacrolimus is given based on body weight.
- Trial name
- NCT00178425
- Testing
- Serial blood sampling as described in protocol, Estimation of Creatinine Clearance at regular intervals
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Rochester
Kidney Transplant; Complications, Muscle Relaxation
Progressive Relaxation Exercises for Kidney Donors
Complex emotions and other possible changes associated with agreeing to enroll after laparoscopic donor nephrectomy may cause living donors to experience anxiety, increase in perceived pain temperature, or last longer after…
- Trial name
- NCT06394245
- Testing
- Progressive muscle exercises
- Volunteers
- 63 people
- Sponsor
- Fenerbahce University
Living Donor Liver Transplantation, Liver Transplantation
Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma
This study is supposed to make liver transplantation available for treatment in well selected patients suffering from non-resectable intrahepatic cholangiocarcinoma.
- Conditions
- Living Donor Liver Transplantation, Liver Transplantation, Neoadjuvant Therapy
- Trial name
- LIVINCA (NCT06539377)
- Testing
- Living donor liver transplantation
- Volunteers
- 6 people
- Sponsor
- Jena University Hospital
Kidney Transplant Rejection
Cellular Immunotherapy in Recipients of Human Leukocyte Antigen (HLA)-Mismatched, Living Donor Kidney Transplants
The Phase 2 primary objective is to evaluate achievement of persistent mixed chimerism and withdrawal of at least one immunosuppression drug for a minimum of 6 months with no episodes of biopsy-proven acute rejection or…
- Trial name
- NCT03605654
- Testing
- MDR-102, Immunosuppressive Agents
- Sponsor
- Medeor Therapeutics, Inc.
ICU Readmission
ICU Readmission in Adult Egyptian Patients Undergoing Living Donor Liver Transplant
Liver transplantation is the only definitive treatment for end stage liver disease. Being a major abdominal surgery, may have postoperative complications that require readmission, which may be serious and life threatening.
- Trial name
- NCT04067739
- Testing
- non interventional study
- Where
- Egypt
- Volunteers
- 299 people
- Sponsor
- Ain Shams University
Chronic Kidney Disease, End Stage Renal Disease
Educating Missouri Patients About Preemptive Living Donor Transplantation
This study is a group-randomized controlled trial to explore whether improved community transplant education for renal patients not yet on dialysis could increase patients' willingness to pursue preemptive living donor transplant…
- Trial name
- NCT01048437
- Testing
- Transplant education with video, Transplant education with speakers
- Where
- 5 sites in United States
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Liver Transplant Rejection
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients.
Our study aimed at studying the impact of gene polymorphism of NFKBIA and PTPN22 genes on rejection episodes in liver transplant Egyptian recipients. Also assess patients' factors associated with graft rejection.
- Trial name
- NCT06060808
- Testing
- gene polymorphism
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Helwan University
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University