Clinical trials: Living-Donor Kidney Transplant
Kidney Failure, Chronic
Induction Therapy Study in Live Donor Kidney Transplant Recipients With a Positive Crossmatch
The purpose of this study is to determine whether the anti-T cell antibody, Thymoglobulin is a more effective induction medication than the anti-IL-2R inhibitor daclizumab, in kidney transplant recipients who have a positive…
- Trial name
- NCT00275509
- Testing
- Thymoglobulin, Daclizumab, Plasmapheresis
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Johns Hopkins University
Kidney Transplantation in Highly Sensitized Patients
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
The goal of this clinical trial is to learn about the efficacy and safety of imlifidase in highly sensitized paediatric patients, 1-17 years old, with end stage renal disease (ESRD).
- Trial name
- DINKY (NCT05753930)
- Testing
- Imlifidase
- Where
- 6 sites in Finland, France and 3 more
- Volunteers
- 10 people
- Sponsor
- Hansa Biopharma AB
Renal Transplantation, Mesenchymal Stem Cells
Mesenchymal Stromal Cells in Living Donor Kidney Transplantation
Kidney transplantation is a good treatment option for people with kidney disease. However, there is still much to learn about how to best care for the transplanted kidney and keep it functioning for a long time.
- Trial name
- NCT03478215
- Testing
- Mesenchymal Stromal Stem Cells (MSCs) Infusion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Methodist Hospital Research Institute
Kidney Transplant
Reducing Disparities in Living Donor Transplant Among African Americans
For most of the patients in the United States with end stage renal disease (ESRD), kidney transplantation represents the optimal treatment, and living donor kidney transplantation (LDKT) is preferable.
- Trial name
- NCT03819686
- Testing
- Living ACTS website, Standard transplant education procedures
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- Emory University
Kidney Transplantation
Live Donors for Kidney Transplants
On a yearly basis there are approximately 12,000 kidney transplants in the United States. Presently there are approximately 40,000 patients awaiting a transplant with only 5,000 available donors.
- Trial name
- NCT00001856
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Transplanted Organ Rejection
A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation
A randomized controlled study to evaluate the safety, efficacy, and overall benefit of FCR001 cell therapy in de novo living donor renal transplantation.
- Trial name
- FREEDOM-1 (NCT03995901)
- Testing
- FCR001
- Where
- 18 sites in United States
- Volunteers
- 15 people
- Sponsor
- Talaris Therapeutics Inc.
Transplant; Failure, Kidney, EBV
Belatacept 3 Month Post Transplant Conversion Study
This study is being done to investigate the impact of changing immunosuppressive medications from tacrolimus (Prograf®) to belatacept (Nulojix®) between three (3) and six (6) months after kidney transplantation.
- Trial name
- NCT02213068
- Testing
- belatacept, Tacrolimus, MPA
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Lorenzo Gallon
Kidney Transplantation, Acute Graft Rejection
Pre-formed Alloreactivity in Renal Transplant Recipients
This investigator-initiated study will analyse the role of pre-formed alloreactive T cells on acute rejection episodes and graft outcome in kidney transplant recipients after living donation.
- Trial name
- NCT02633826
- Where
- 13 sites in Germany
- Volunteers
- 190 people
- Sponsor
- Martina Sester
Kidney Insufficiency
Rituximab Therapy for Patients on Kidney Transplant Waiting List With Positive Donor Specific Crossmatch to Living Donor
Primary Objectives: Conversion of a positive donor specific cross-match to a living donor to a negative cross-match thereby allowing successful renal transplantation.
- Trial name
- NCT00476515
- Testing
- Rituximab
- Sponsor
- Massachusetts General Hospital
Chronic Post Operative Pain, Kidney Transplant; Complications
Post-surgical Chronic Pain After Retroperitoneal Laparoscopic Living Kidney Donor
This study aimed to determine the relationship between the quadratus lumborum and erector spinae plane block technique and the incidence and severity of chronic post-surgical pain in accordance with Brief Pain Inventory Score…
- Conditions
- Chronic Post Operative Pain, Kidney Transplant; Complications, Anesthesia Regional, Laparoscopy
- Trial name
- NCT05572775
- Testing
- Quadratus lumborum (QL) block, Erector Spinae Plane (ESP) Block
- Where
- Indonesia
- Volunteers
- 146 people
- Sponsor
- Universitas Indonesia
Immune Tolerance
Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation
This research study is to determine if donor blood stem cells given after living, related, HLA antigen (Ag) haplotype match or living, unrelated donor kidney transplantation.
- Trial name
- CIRM (NCT03292445)
- Testing
- Immune tolerance after kidney transplant, Donor blood stem cells and T cells
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Strober
Renal Failure
Impact of Donor-Specific Antibodies in (Highly-) Immunized Living Donor Kidney Transplant Recipients
Kidney transplantation is the preferred treatment for end-stage renal disease. Alongside limited availability of donors, rejection and premature graft loss are main barriers to kidney transplantation.
- Trial name
- NCT05431712
- Volunteers
- 252 people
- Sponsor
- Erasmus Medical Center
Kidney Failure
Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor FCRx Infusion
An open-label study to assess the safety, efficacy, and tolerance of FCRx cell therapy in adult recipients within 12 months after kidney transplantation from a living donor.
- Trial name
- NCT00497926
- Testing
- Enriched Hematopoietic Stem Cell Infusion
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Talaris Therapeutics Inc.
Living-Donor Kidney Transplant
Thymoglobulin Versus Campath-1H Versus Daclizumab in Adult, Primary Living Donor Renal Transplantation
To observe in a randomized prospective pilot study the effectiveness and toxicity of Thymoglobulin vs. Campath-1H used for induction therapy in recipients of living donor (LD) kidneys, compared with our standard treatment…
- Trial name
- NCT00681343
- Testing
- Thymoglobulin, Campath-1H, Daclizumab
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Miami
Transplant Donation
Information-Assisted Intervention for Potential Living Kidney Donors
This study aims to evaluate the effectiveness of an information-assisted intervention in enhancing knowledge, decision self-efficacy, and reducing decisional conflict among potential living kidney donors.
- Trial name
- NCT07243717
- Testing
- Information-Assisted Intervention
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Kidney Diseases, Kidney Failure, Chronic
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
The purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation
- Conditions
- Kidney Diseases, Kidney Failure, Chronic, Kidney Failure, Renal Insufficiency
- Trial name
- NCT01289548
- Testing
- remote ischaemic preconditioning
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Immunosuppressive Treatment of Living-donor Renal Transplantation
The ONE Study nTreg Trial (ONEnTreg13)
The aim of this trial is to collect evidence of the safety of administering autologous CD4+CD25+FoxP3+ natural regulatory T cells (nTregs) to living-donor renal transplant recipients.
- Trial name
- ONEnTreg13 (NCT02371434)
- Testing
- autologous CD4+CD25+FoxP3+ natural regulat. T cells (nTregs)
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Prof. Dr. Petra Reinke
Living Donor Kidney Transplantation
Multidisciplinary Support To Access Living Donor Kidney Transplant-Pilot
For patients with kidney failure the two treatment options are kidney transplantation or dialysis. Transplantation offers longer survival, better quality of life and provides cost savings for the health system (>$60,000/year per…
- Trial name
- MuST AKT (NCT04666545)
- Testing
- MuST AKT
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Kidney Transplant Rejection, Kidney Transplant; Complications
Basiliximab vs Low-dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients
Demonstrate that low dose (3 mg/kg total ) rATG (thymoglobulin) has similar efficacy (delayed graft function, slow graft function, biopsy proven acute rejection episodes, infections, hospitalizations, adverse events, graft loss…
- Trial name
- NCT03006419
- Testing
- Basiliximab, Thymoglobulin
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Kidney Transplant, Kidney Transplant Donor
Outcomes of a Pre-operative Exercise Programme for Live Donor and Recipient Kidney Transplant Patients
The goal of this clinical trial is to learn if a pre-operative outpatient exercise programme, monitored by a smart wearable device is acceptable to live kidney donor and recipient transplant patients.
- Conditions
- Kidney Transplant, Kidney Transplant Donor, Kidney Transplant Recipient
- Trial name
- OPERATe (NCT06858098)
- Testing
- Exercise programme, Wearable smart device
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Manchester