Clinical trials: Local; Infection
Tuberculosis
Study Evaluating Aerosol and Intradermal Administration of a Candidate Tuberculosis (TB) Vaccine, MVA85A, as a Way to Increase Immune Response and Avoid Anti-vector Immunity
Boost vaccinations sometimes have no effect because the body has got used to the vaccine and no longer reacts to it. We are therefore investigating whether vaccinating with aerosolised MVA85A (a candidate tuberculosis vaccine)…
- Trial name
- NCT01954563
- Testing
- MVA85A
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Surgical Complication
The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery
Study objective: This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound…
- Trial name
- TRANOP (NCT06270407)
- Testing
- Tranexamic Acid 100 MG/ML, 0.9%sodium chloride
- Where
- 11 sites in Denmark, Finland and 1 more
- Volunteers
- 3,000 people
- Sponsor
- St. Olavs Hospital
Surgical Site Infection (SSI)
Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic
Surgical site infections were defined as infections that developed in the area of an operation within 30 days after surgery. They remained a common problem after surgery and could increase pain, delay wound healing, prolong…
- Trial name
- NCT07478874
- Testing
- Cefazolin plus Gentamicin, Cefazolin
- Where
- Pakistan
- Volunteers
- 284 people
- Sponsor
- Lahore General Hospital
Chronic Hepatitis B
Safety Study of HBV DNA Vaccine to Treat Patients With Chronic Hepatitis B Infection
The purpose of this study is to evaluate how well the vaccine is tolerated at sites where administrations are given and any effects it may have on subjects' wellbeing.
- Trial name
- NCT00277576
- Testing
- ppdpSC18 administered by PMED
- Where
- 9 sites in Hong Kong, Singapore and 2 more
- Volunteers
- 48 people
- Sponsor
- PowderMed
Common Cold
Warming Sensation and Tolerability Study of Acetylcysteine 2% Oral Solution for Productive Cough
This is a 1-treatment arm, open label design. This 1-day study includes a screening on day of attendance at clinic, followed by a washout period of 30 minutes to 8 hours (if participants are eligible for dosing the same day).
- Trial name
- NCT02822287
- Testing
- Acetylcystine
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- GlaxoSmithKline
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer
RATIONALE: Taking part in a clinical trial may help children with cancer receive more effective treatment. PURPOSE: Determine why patients who are eligible for protocols made available through the Pediatric Oncology Group do not…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Leukemia
- Trial name
- NCT00002485
- Testing
- psychosocial assessment and care
- Where
- 31 sites in United States, Canada and 2 more
- Volunteers
- 359 people
- Sponsor
- Children's Oncology Group
Burkitt Lymphoma, KSHV-associated Multicentric Castleman Disease
Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in Uganda
This phase I trial studies how well rituximab hyaluronidase and combination chemotherapy work in treating patients in Uganda with Burkitt lymphoma, diffuse large B-cell lymphoma, or Kaposi sarcoma herpesvirus associated…
- Conditions
- Burkitt Lymphoma, KSHV-associated Multicentric Castleman Disease, Diffuse Large B-Cell Lymphoma
- Trial name
- NCT03864419
- Testing
- Rituximab and Hyaluronidase Human, Cyclophosphamide, Vincristine
- Where
- Uganda
- Volunteers
- 18 people
- Sponsor
- Fred Hutchinson Cancer Center
Pneumonia
Impact of a Regional Antimicrobial Stewardship on the Length of Stay of Patients Admitted to Hospital With Pneumonia
This study evaluates the effectiveness of an antimicrobial stewardship program to reduce the length of stay of patients admitted to hospital with a diagnosis of pneumonia.
- Trial name
- RASPCAP (NCT02276092)
- Testing
- antimicrobial stewardship
- Where
- Canada
- Volunteers
- 1,400 people
- Sponsor
- Royal Victoria Hospital, Canada
Radius Fracture Distal, Surgery
Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up
A 10-year follow up of a fusion of two earlier published randomized controlled trials. 203 patients with displaced distal radius fractures were randomized to surgery with a volar locking plate or external fixation.
- Conditions
- Radius Fracture Distal, Surgery, Surgery--Complications, Treatment Complication
- Trial name
- EXTEND (NCT05371938)
- Testing
- Volar locking plate, external fixation
- Where
- Sweden
- Volunteers
- 203 people
- Sponsor
- Olof Skoldenberg
Tension-Type Headache, Orofacial Pain
Laser Therapy on Tension-type Cephalea and Orofacial Pain in Post-covid-19 Patients
Considering the auxiliary potential effect of photobiomodulation in controlling persistent CTT and TMD-related pain in patients who have been diagnosed with COVID-19, and are recovered from the viral infection, we intend to…
- Conditions
- Tension-Type Headache, Orofacial Pain, COVID-19
- Trial name
- NCT05430776
- Testing
- Photobimodulation
- Where
- 2 sites in Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Herpes Zoster, Local Infiltration
Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain
Herpes zoster (HZ) is a skin infection disease which cause severe zoster-associated pain (ZAP) along sensory nerve in the corresponding segment.
- Conditions
- Herpes Zoster, Local Infiltration, Acute Pain
- Trial name
- NCT06344403
- Testing
- analgesic, Tender point infiltration
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Beijing Tiantan Hospital
Rheumatic Heart Disease, Pregnancy
Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease
The hemodynamic parameters of 31 pregnant women with rheumatic valve disease, undergoing restorative dentistry under local anesthesia with 2% solution of lidocaine, divided in two groups, with (Group LE) and without 1:100,000…
- Conditions
- Rheumatic Heart Disease, Pregnancy, Dental Caries
- Trial name
- NCT00482573
- Testing
- Dental local anesthesia
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Wound Complication, Cardiac Surgery
Effectiveness of Topical Vancomycin in Reducing Sternal Wound Infections Post-Cardiac Surgery
Title: The Role of Vancomycin Powder in Reducing Sternal Wound Infections Following Cardiac Surgery: A Randomized Controlled Trial Introduction: Sternal wound infections (SWIs) are significant complications in cardiac surgery…
- Trial name
- NCT06651268
- Testing
- while Group B (vancomycin group, n=12) had vancomycin powder applied during closure. T
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Liaquat National Hospital & Medical College
Hiv
Regional Multicenter Study to Evaluate Tolerability and Efficacy of TAF/FTC/RPV Combination (ODEFSEY ®) in Prevention of Sexual or Blood Exposure to HIV
Prospective, multicenter study to evaluate tolerability, adherence and efficacy of a 28-day course of TAF/FTC/RPV, an HIV post-exposure prophylaxis after a potential sexual or blood exposure to HIV.
- Trial name
- AES ODEFSEY (NCT03451032)
- Testing
- Non Interventional Study
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Infectious Diseases
Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics
The physicians have few options for skin antisepsis. Alternatives for common use antiseptics are costly or ineffective. In order to have more options, this study is needed.
- Trial name
- NCT01321125
- Testing
- Bacterial culture of the prepared skin's areas, Preparing skin's areas to be tested, Antiseptic substantivity
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Inflammation, Burns
Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing
The purpose of this study is to evaluate the change in signs of inflammation/local infection when Mepilex Border Ag is used in normal clinical practice when used on chronic ulcers (venous leg, diabetic foot and pressure ulcers)…
- Conditions
- Inflammation, Burns, Ulcers
- Trial name
- NCT01214811
- Testing
- Mepilex Border Ag
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Molnlycke Health Care AB
Catheter Infection
Local Inflammation Does Not Correlate With Bacterial Colonization and Contamination of Perineural Catheters
The aim of this study was to investigate the influence of alcoholic skin disin-fection before PNC (perineural catheter)-removal on the detection of bacteria on the subcutaneous part of the PNC or on the tip.
- Trial name
- NCT02599181
- Testing
- propanol-biphenol: Kodan
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Covid19
Public Health Emergency: SOLIDARITY TRIAL Philippines
This study is an adaptive, randomized, open-label, controlled clinical trial utilizing an adaptive design to compare effects of repurposed drugs with local standard of care alone on major inpatient hospital outcomes.
- Trial name
- NCT05024006
- Testing
- Remdesivir, Hydroxychloroquine, Lopinavir / Ritonavir
- Where
- 25 sites in Philippines
- Volunteers
- 1,314 people
- Sponsor
- University of the Philippines
HIV Infections, Hepatitis B, Chronic
Safety and Acceptability of a Vaginal Microbicide
The purpose of this study is to determine the safety and acceptability of a vaginal microbicide in HIV uninfected sexually active women.
- Trial name
- NCT00111943
- Testing
- 1% tenofovir gel
- Where
- 3 sites in United States, India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Appendicitis
A Comparison of UGBRS Block and Local Infiltration
In this research study, the investigators are trying to find out which of the two methods of injecting local anesthetics (at the site of the belly button cut or by ultrasound guided rectus sheath block) will provide better pain…
- Trial name
- NCT02352519
- Testing
- UGBRSB, Local Infiltration
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine