Clinical trials: Local Adverse Effects
Hip Fracture, Postoperative Pain
Effect of PENG Block on Postoperative Tramadol Consumption in Partial Hip Prosthesis Surgery
This study aims to evaluate the effect of ultrasound-guided pericapsular nerve group (PENG) block on postoperative tramadol consumption, pain scores, and clinical outcomes in patients undergoing partial hip prosthesis surgery.
- Trial name
- PENG-PKP (NCT07534137)
- Testing
- PENG Block, General Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- University of Gaziantep
Cataract Surgery, Patient Satisfaction
Evaluation of Duration of Anesthesia and Patient Satisfaction After Retrobulbar Block Applied in Cataract Surgery
It is aimed to determine patient satisfaction (pain assessment during and after the operation) and the initial and total anesthesia durations of eye lid and globe anesthesia after administration of local anesthetic solution only…
- Conditions
- Cataract Surgery, Patient Satisfaction, Akinesia, Anesthesia, Local
- Trial name
- NCT04178200
- Testing
- Lidocaine 2% Injectable Solution 0.75 ml, Bupivacaine Hcl 0.5% Inj 0.75 ml, Lidocaine 2% Injectable Solution 1.5 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Develi Devlet Hastanesi
Poisoning by BCG Vaccine
Influence of Hyaluronic Acid on Bacillus Calmette-Guérin Local Side Effects
The purpose of this study is to evaluate a possible role of intravesical Hyaluronic Acid in reducing local toxicity of Bacillus Calmette Guerin (BCG) used to treat bladder urothelial cell carcinoma.
- Trial name
- NCT02207608
- Testing
- Hyaluronic Acid, BCG (Immucist®)
- Volunteers
- 30 people
- Sponsor
- University of Rome Tor Vergata
Child With Adverse Drug Reactions
Adverse Drug Reactions in Pediatrics: Experience of a Regional Pharmacovigilance Center
Aim. - To describe the adverse drug reactions (ADR) and the drugs involved in pediatrics. Methods. - An observational study on all ADR notifications recorded in the French pharmaco-vigilance database by the Regional…
- Trial name
- Pediatry ADR (NCT03316014)
- Testing
- Adverse drug reaction
- Volunteers
- 632 people
- Sponsor
- CHU de Reims
Umbilical Hernia
Analgesic Efficacy After Umbilical Hernia Repair in Children
Umbilical hernia repair is a common painful outpatient procedure performed in children. Often analgesia for this procedure is provided by using local infiltration of the surgical site by the surgeons and perioperative opioids and…
- Trial name
- NCT00578136
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Children's Hospital of Philadelphia
Breast Cancer
Dose Optimization for Pulsed-dose-rate (PDR)/High-dose-rate (HDR) Brachytherapy Alone for Early Breast Cancer
Accelerated partial breast irradiation (APBI) leads to a equivalent local control rate with lower toxicity as external beam irradiation (EBI) after breast conserving surgery (BCS) in a highly selected subgroup of patients with…
- Trial name
- NCT01175694
- Testing
- Interstitial multicatheter brachytherapy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Erlangen
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural
Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Aim of this study is to determine whether Inferior Vena Cava analyzed by trans-thoracic echocardiography is an effective method to guide titrated fluid repletion in non critical patients, in order both to decrease post procedural…
- Conditions
- Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural, Regional Anesthesia Morbidity
- Trial name
- NCT02271477
- Testing
- Ultrasound-guided volemic repletion
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Drug Toxicity
Regional Data Exchange to Improve Medication Safety
Medication reconciliation, a process by which a provider obtains and documents a thorough medication history with specific attention to comparing current and previous medication use, can prevent medication-related errors and…
- Trial name
- NCT01239121
- Testing
- HIE-Enhanced Medication Reconciliation, Optimal Medication Reconciliation without HIE
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Palmar-plantar Erythrodysesthesia
F511 Cream in Preventing Palmar-Plantar Erythrodysesthesia in Patients Receiving Doxorubicin Hydrochloride Liposome for Metastatic Breast Cancer
RATIONALE: F511 cream may prevent or reduce palmar-plantar erythrodysesthesia in women receiving doxorubicin hydrochloride liposome for metastatic breast cancer.
- Trial name
- NCT00992706
- Testing
- antiperspirant cream F511, pegylated liposomal doxorubicin hydrochloride
- Where
- 15 sites in Switzerland
- Volunteers
- 91 people
- Sponsor
- Swiss Cancer Institute
Cancer
Impact of a Coordinated Regional Organization to Secure Patient's Care Treated by Oral Antineoplastic Agents
The purpose is to estimate evolution of patients treated by oral neoplastic agents, in term of early or unforeseen recourse to the hospital for adverse events.
- Trial name
- CHIMORAL (NCT01947296)
- Where
- France
- Volunteers
- 284 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bed Bathing
A Double-blind Evaluation of Adverse Effects of Bath With Wipes Impregnated With 2% Chlorhexidine Versus Placebo
Traditional bed bathing have been related to cross-infection. In order to avoid this complication, single-use products such as wipes impregnated with chlorhexidine use is increasing.
- Trial name
- NCT02096094
- Testing
- Standardization phase, Control bath, Bath with chlorhexidine
- Where
- Mexico
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Neuralgia, Neuropathic Pain
PK of Lidocaine/Tetracaine and PD Derived From a New Topical Formulation for Treatment of Neuropathic Pain.
Post-herpetic neuralgia (PHN) is the most frequent complications related to herpes zoster, and can persist for months or even years, and require extensive treatment.
- Conditions
- Neuralgia, Neuropathic Pain, Local Anesthetic Complication, Lidocaine Adverse Reaction
- Trial name
- PK/PDLido (NCT06171243)
- Testing
- Lidocaine topical
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Wound Heal, Wound Surgical
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part II
The purpose of the present study is to evaluate the influence of the post-surgical chlorhexidine indication in the gene expression profile and cellular behavior in the early wound healing process -24 hours after injury- of the…
- Conditions
- Wound Heal, Wound Surgical, Oral Soft Tissue Conditions, Chlorhexidine Adverse Reaction
- Trial name
- NCT04276129
- Testing
- periodontal surgery + 24 hr buccal attached gingiva (G) biopsy, post-surgical CHX mouth-rinses indication
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- University of Roma La Sapienza
Anesthesia; Adverse Effect, Spinal and Epidural
Comparative Study Between Bilateral and Unilateral Spinal Anaesthesia
The purpose of this study is to compare unilateral spinal anesthesia using hyperbaric Prilocaine with "classical bilateral spinal anesthesia" using plain Prilocaine according to block characteristics and quality of micturition…
- Trial name
- NCT01877356
- Testing
- bilateral spinal anesthesia, unilateral spinal anesthesia
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Hospital, Antwerp
Prostate Cancer, Adverse Effects Surgery
TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer
This study is set up as a phase I prospective, single center, device interventional pilot study carried in office setting under local anesthesia.
- Conditions
- Prostate Cancer, Adverse Effects Surgery, MRI, Ultrasound
- Trial name
- TPF-LITT (NCT05698576)
- Testing
- TRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Urological Research Network, LLC
Anesthesia; Adverse Effect, Anesthesia, Local
Impatto Emodinamico Dell'Anestesia Subaracnoidea Titrata Versus Tecnica Single-shot Nei Pazienti Sottoposti ad Artroprotesi d'Anca. RCT
Studying the hemodynamic effects of titrated subarachnoid anesthesia versus conventional single-shot subarachnoid anesthesia
- Trial name
- NINO (NCT05868642)
- Testing
- subarachnoid block
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Istituto Ortopedico Rizzoli
Anesthesia, Conduction, Nerve Block
Neurologic Complications in Peripheral Regional Anesthesia - An Evaluation Based on a Standardized Protocol
To evaluate the incidence of neurologic complications as a consequence of peripheral regional anesthesia, all patients receiving peripheral nerve blocks will be evaluated according to a standardized protocol screening pain…
- Conditions
- Anesthesia, Conduction, Nerve Block, Adverse Effects
- Trial name
- NCT00445016
- Testing
- peripheral regional anesthesia
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- BG Unfallklinik Murnau
Post Operative Pain, Regional Anesthesia Morbidity
Does ESP Block Reduce Pain and Opiates Consumption After Surgery
The patients will be randomly assigned to standard therapy or standard therapy+ESP nerve block. After surgery pain level and narcotic consumption will be measured, and vital signs and side effects will bo monitored for up to 72…
- Conditions
- Post Operative Pain, Regional Anesthesia Morbidity, Opioid-Related Disorders, Chronic Pain
- Trial name
- NCT05512897
- Testing
- erector spinea plane block
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michael Dubilet MD
Dermatitis
Olive Oil With Omega 3 to Treat Stasis Dermatitis
Olive oil and Omega 3 have many anti inflammatory effects that may be beneficial in the inflammation and edema of chronic stasis dermatitis.
- Trial name
- NCT00421161
- Testing
- olive oil and omega 3 in a combined cream
- Where
- 3 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center