Clinical trials: Local Anesthesia
Pain, Postoperative
Exparel vs. Standard Bupivicaine for Abdominoplasty
Background \& study question: Strategies for post-operative pain control that make use of various different types of medicines are advantageous both for patient comfort and for minimizing the use of opioid pain medicines and…
- Trial name
- NCT01853176
- Testing
- Liposomal Injection Bupivacaine (Exparel), Standard bupivicaine
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Emory University
Dental Pain
Buffered Local Anesthetic
The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of…
- Trial name
- NCT05757648
- Testing
- Non-buffered Anesthetic, Buffered Anesthetic, Onset
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pain Management
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
Opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids.
- Trial name
- NCT03757715
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Tibial Fractures
Intra-articular Local Anesthetic Injection and Hematoma Aspiration
The primary objective of this study is to determine whether a patient with a tibial plateau fracture (non-displaced, displaced, or depression type) will have decreased pain and narcotic analgesia requirements following an…
- Trial name
- NCT02951884
- Testing
- Aspiration, Bupivacaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Loyola University
Anesthesia, Local, Pain
Evaluation of the Dental Vibe Injection Comfort System
This study investigated the Dental Vibe Injection Comfort System (DV), developed to lessen anesthesia pain through pulsed vibration, a form of counter-stimulation.
- Trial name
- DVRCT (NCT04971941)
- Testing
- Dental Vibe
- Volunteers
- 60 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Disc Herniation, Lumbosacral Radiculopathy
CT Guided Injection for Low Back Radiculopathy: A Randomized Clinical Trial
Herniated disc sometimes cause back pain radiating down to a leg. This pain can be so severe that it is functionally disabling. The purpose of this randomized clinical trial is to determine if corticosteroid medication, delivered…
- Trial name
- NCT01267825
- Testing
- CT-guided corticosteroid+ bupivicaine, Standard medical care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Breast Surgery
Erector Spinae Versus Paravertebral Nerve Blocks for Breast Surgery
Following painful surgical procedures of the breast, postoperative analgesia is often provided with a paravertebral nerve block (PVB).
- Trial name
- NCT03549234
- Testing
- Erector Spinae (single injection), Paravertebral (single injection)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Osteoarthritis of Hip, Regional Anesthesia
Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
The purpose of this research study is to evaluate the analgesic efficacy of adding a single shot parasacral (sciatic) nerve block to a continuous lumbar plexus block in patients undergoing total hip replacement.
- Conditions
- Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty
- Trial name
- NCT02161484
- Testing
- Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rita Merman
Postoperative Pain, Objective Assessment of Sedation
Infrared Pupillometry During General Anesthesia to Predict Pain
The study comprises of a series of pupillary measurements using infrared pupillometry in patients undergoing arthroscopic knee surgery of any type.
- Trial name
- NCT02058511
- Testing
- Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Chronic Low Back Pain
Comparison of Kinesio Taping and Local Injection in Chronic Low Back Pain
Low back pain can be seen in every period of life. More than 80 percent of the society complain of low back pain at any time of life.
- Trial name
- NCT03895307
- Testing
- kinesio tape, local anesthetic, local serum physiologic
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pregnancy
Local Anesthesia and Pain Perception During an Amniocentesis
This study is been designed to answer the question of whether local anesthesia (1% lidocaine) decreases the perception of pain associated with amniocentesis in a randomized double blind placebo controlled manner.
- Trial name
- NCT00583011
- Testing
- Local Anesthesia
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pain
Effectiveness Study of Different Local Anesthetic Mixtures
Purpose and Background The purpose of this research study is to investigate the benefits of mixing lidocaine and bupivacaine for numbing the skin.
- Trial name
- CA (NCT01243112)
- Testing
- 1% Lidocaine with Epinephrine (1:100,000), 0.25% Bupivacaine with Epinephrine (1:200,000), 0.5% Lidocaine, 0.125 Bupivacaine, and epi (1:150,000)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Postoperative Pain
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management
To evaluate the efficacy of bilateral continuous erector spinae blocks (BESB) for postoperative analgesia in children and adolescents undergoing cardiac surgical procedures via sternotomy in the Early Recovery After Surgery…
- Trial name
- NCT04567407
- Testing
- Bilateral erector spinae blocks using ropivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Tourniquet Hypertension, Intraoperative Hypertension
Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension
The purpose of this prospective randomized double-blind study is to determine if the novel technique of ultrasound guided peri-arterial injection of local anesthetic around the femoral artery decreases ischemic hypertension…
- Conditions
- Tourniquet Hypertension, Intraoperative Hypertension, Total Ankle Arthroplasty, Ankle Fusion
- Trial name
- NCT03390426
- Testing
- Mepivacaine, Perifemoral Injection of Local Anesthetic, Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Anesthesia, Glycocalyx
Effect General and Regional Anesthesia on Glycocalyx
Observational study evaluating effect general or regional anaesthesia on glycocalyx by using perfused Boundary Region in sublingual microcirculation.
- Conditions
- Anesthesia, Glycocalyx, Perfused Boundary Region
- Trial name
- NCT02783443
- Testing
- General anesthesia, Regional anesthesia
- Volunteers
- 60 people
- Sponsor
- University Hospital Hradec Kralove
Saphenous Nerve Block
Saphenous Nerve Block for Foot and Ankle Surgery
Patients undergoing foot and ankle surgery have the option of having a nerve block administered by their Anesthesiologist. The nerve block numbs the foot and results in less post-operative nausea and vomiting, and better pain…
- Trial name
- NCT02382744
- Testing
- Ultrasound Guidance, Ultrasound guidance + nerve stimulation
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hip Fractures
Regional Versus General Anesthesia for Promoting Independence After Hip Fracture
The purpose of this study is to find out if two types of standard care anesthesia are the same or if one is better for people who have hip fractures.
- Trial name
- REGAIN (NCT02507505)
- Testing
- Regional Anesthesia, General Anesthesia
- Where
- 45 sites in United States, Canada
- Volunteers
- 1,848 people
- Sponsor
- University of Pennsylvania
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Anesthesia, Caudal
Caudal Block Versus Local Wound Infiltration for Inguinal Procedures
Single-centre observational study to analyse whether there is a difference in post-operative pain scores and set up time when comparing caudal block with local wound infiltration
- Trial name
- NCT04590027
- Volunteers
- 86 people
- Sponsor
- University Hospital Tuebingen
Pain Control for Intrauterine Device Insertions
Paracervical Block Before Intrauterine Device (IUD) Insertion
The purpose of this study is to evaluate if a paracervical block containing 1% lidocaine administered prior to IUD insertion reduces insertion pain.
- Trial name
- NCT01207401
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northwestern University