Clinical trials: Local Anesthetic Effectiveness
Efficacy of Drugs in Pain Management
Dexamethasone Versus Dexmedetomidine in IPACK Block to Reduce Pain Post Arthroscopic Knee Surgeries
The investigators will test the effects of dexamethasone versus dexmedetomidine as adjuvant to bupivacaine in IPACK Block and it's direct effect in decreasing pain post operative following Arthroscopic knee surgeries
- Trial name
- NCT07024043
- Testing
- Dexamethasone versus Dexmedetomidine in IPACK Block to reduce pain post Arthroscopic knee surgeries, IPACK and multi-modal analgesic regimen
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Referred
Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section
The purpose of this study is to determine if giving an injection of numbing medication at the incision at the end of cesarean will help control pain AFTER cesarean delivery.
- Trial name
- NCT03383588
- Testing
- Bupivacaine, Morphine, Fentanyl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Axillary Brachial Plexus Block
Determining the Minimum Effective Volume of Local Anesthetic for Ultrasound-guided Axillary Brachial Plexus Block
This is a study to calculate the minimum effective volume of bupivacaine 0,5% with epinephrine for successful axillary brachial plexus block for hand surgery in 50% of the patients (MEV50).
- Trial name
- NCT01421914
- Testing
- Bupivacaine 0,5%
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Federal University of São Paulo
Postoperative Pain
TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy
Major abdominal surgeries are associated with severe abdominal pain, which can affect respiratory and cardiac functions, if insufficiently managed. This increases the incidence of post-operative morbidity.
- Trial name
- NCT02930707
- Testing
- Magnesium Sulfate, Bupivacaine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Low-level-laser Theraphy, Anesthesia, Local
Anethesia Efficacy on Teeth With MIH (Molar Incisor Hypomineralisation)
Difficulty in achieving anesthesia in teeth with molar incisor hypomineralisation (MIH) is a frequently reported clinical problem.
- Conditions
- Low-level-laser Theraphy, Anesthesia, Local, Molar Incisor Hypomineralization
- Trial name
- MIH (NCT05344014)
- Testing
- Photobiomodulation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Postoperative Pain
Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy
Effective post-surgical pain management is a crucial component of a patient's postoperative course following posterior colporrhaphy.
- Trial name
- NCT04032327
- Testing
- Exparel plus plain bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Walter Reed National Military Medical Center
Breast Cancer
The Analgesic Efficacy of the Pectoral Nerves Block Versus Local Anesthetic Infiltration After Mastectomy
This trial will include patients undergoing radical mastectomy under general anesthesia. One group of patients will receive a pectoral nerve block, done by the anesthetist under ultrasound guidance at the beginning of the…
- Trial name
- PECS (NCT04116021)
- Testing
- PECS block, Local infiltration
- Volunteers
- 50 people
- Sponsor
- Hôpital du Valais
Minimum Effective Concentration of Local Anesthetic
The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block
The aim of this study is to determine the minimum effective concentration of local anesthetic (ropivacaine 40mL) required to produce an effective double-injection USG-SCB for surgical anesthesia in 90% of patients (MEC90) in…
- Trial name
- NCT02286336
- Testing
- brachial plexus block
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Huazhong University of Science and Technology
Cholelithiasis, Cholecystectomy, Laparoscopic
Unilateral Laparoscopic TAP Block vs. Local Infiltration in Post-Cholecystectomy Analgesia
This study compared different methods of pain control after laparoscopic gallbladder removal. A total of 160 patients were randomly assigned to receive either a unilateral laparoscopic TAP block, local anesthetic infiltration, a…
- Conditions
- Cholelithiasis, Cholecystectomy, Laparoscopic, Pain, Postoperative, Anesthesia, Local
- Trial name
- TAP vs LAI (NCT07176299)
- Testing
- Unilateral laparoscopic TAP block (0.25% bupivacaine), Local anesthetic infiltration (0.25% bupivacaine), Combined TAP block and local anesthetic infiltration (0.25% bupivacaine)
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Pain
Local Infiltration Analgesia for Hip Arthroscopy
The purpose of this study is to examine if ultrasound guided infiltration of local anesthetic solution around the hip joint will provide effective pain control after hip arthroscopy.
- Trial name
- NCT01454518
- Testing
- Infiltration of local anesthetic, Normal Saline Injection
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Trinity Health Of New England
Postoperative Pain
PAIN - Postoperative Analgesia INvestigation
The purpose of this study is to assess the efficacy of the intraoperative injection of prolonged acting (liposomal) bupivacaine in postoperative pain control after truncal surgical incisions.
- Trial name
- PAIN (NCT02111746)
- Testing
- Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The University of Texas Health Science Center, Houston
Local Anesthesia Infiltration
Efficacy of Facial Massager in Reducing Intra Oral Injection Pain in Pediatric Patients
Abstract Background: Local anesthesia is a primary source of anxiety in pediatric dentistry. Objective: To evaluate if mechanical vibration from a low-cost facial massager reduces pain and anxiety during injections using the Gate…
- Trial name
- NCT07682181
- Testing
- Facial T massager, Topical Benzocaine 20%
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Hospital, India
Low Back Pain, Lumbago
Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies.
The treatment of chronic low back pain is a major objective of public healthcare, because it causes an important number of sick leaves.
- Conditions
- Low Back Pain, Lumbago, Modic I Discopathy
- Trial name
- MODISC (NCT01694134)
- Testing
- Hydrocortancyl., Lidocaine
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Soft Tissue Injuries
Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children
Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures.
- Trial name
- NCT05448807
- Testing
- OraVerse
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Scalp Nerve Block, Craniotomy Surgery
The Efficacy of Regional Scalp Block in Craniotomy
The objective of this clinical trial is to evaluate the role of scalp nerve block in craniotomy. The primary questions it seeks to answer are: What are the efficacy and safety profiles of scalp nerve block in craniotomy? The…
- Trial name
- NCT06720285
- Testing
- nerve block with 0.5% ropivacaine, General anesthesia and opioids (fentanyl, propofol, rocuronium)
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Airlangga
Regional Anesthesia, Ultrasound
Maximal Distance for Successful Supraclavicular Block
The achievement of peripheral nerve block requires several needle passes, with each of them being at risk of causing nerve injury either by direct trauma or intraneural injection even with the use of the ultrasound.
- Conditions
- Regional Anesthesia, Ultrasound, Supraclavicular Block
- Trial name
- NCT02383134
- Volunteers
- 44 people
- Sponsor
- Tunisian Military Hospital
Analgesia
Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion
This study aims to assess Effectiveness of Pre-administered Natural Sweet-tasting Solution (honey) for Decreasing Pain Associated with Dental Injections (infiltration) prior to dental extraction in 6-8 years old healthy Children…
- Trial name
- NCT06393777
- Testing
- honey
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Brachial Plexus Blockade, Shoulder Surgery
Dose-Finding Study: MEV90 for Local Anesthetic in Interscalene Block for Supraclavicular Nerves Block
This study aims to determine the minimum effective volume (MEV90) of local anesthetic required to achieve sensory block of the supraclavicular nerves when performing a single-shot ultrasound-guided interscalene brachial plexus…
- Conditions
- Brachial Plexus Blockade, Shoulder Surgery, Superficial Cervical Plexus Block
- Trial name
- NCT07338916
- Testing
- Ultrasound-Guided Interscalene Block with Bupivacaine
- Where
- Chile
- Volunteers
- 57 people
- Sponsor
- Hospital del Trabajador de Santiago
Hair Diseases
Local Anesthesia and Electronic Injector
Local anesthesia-related pain is associated with injection speed. An electronic constant-speed injector was developed for slow and steady injection to alleviate dermatological anesthesia pain.
- Trial name
- NCT06395545
- Testing
- Electronic injector
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Anesthesia
Minimum Effective Volume of Local Anesthetic Using Ultrasound for Brachial Plexus Block
The purpose of this study is to determine the minimum effective volume of local anesthetic for interscalene brachial plexus block using ultrasound guidance and nerve stimulator guidance.
- Trial name
- NCT01244932
- Testing
- bupivacaine 0.5%
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo