Clinical trials: Local Anesthetic Effectiveness
Anesthesia, Local, Intravitreal Injection
Cooling Anesthesia for Intravitreal Injection
The purpose of this clinical study is to evaluate the safety and efficacy of cooling anesthesia application to the eye as anesthesia for intravitreal injection using a novel cooling anesthesia device and determine the effects of…
- Conditions
- Anesthesia, Local, Intravitreal Injection, Macular Degeneration, Diabetic Macular Edema
- Trial name
- COOL-1 (NCT03732287)
- Testing
- Cooling Anesthesia
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Recens Medical, Inc.
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Hemorrhoids
Local Anaesthetic Day-care Haemorrhoidectomy Challenges Traditional Concepts - a Randomised Controlled Trial
Background: Local anaesthetic day-care open haemorrhoidectomy (LH) is feasible, cheap and may be the cost-effective surgical approach to third degree haemorrhoids.
- Trial name
- NCT00503269
- Testing
- Hemorrhoidectomy
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Benign Prostate Hyperplasia
Safety, Efficacy, and Short-Term Outcomes of Rezūm Water Vapor Thermal Therapy for Benign Prostatic Hyperplasia Under Local Anesthesia With Intravenous Sedation: A Single-Center Retrospective Study of 129 Patients in the Kurdistan Region of Iraq
This single-center retrospective study evaluates the safety, feasibility, and short-term clinical outcomes of Rezūm water vapor thermal therapy (WVTT) for the treatment of lower urinary tract symptoms (LUTS) secondary to benign…
- Trial name
- NCT07507591
- Testing
- Rezum Water Vapor Thermal Therapy
- Where
- Iraq
- Volunteers
- 129 people
- Sponsor
- ALI KAMAL M. SAMI
Local Anesthetics, Tooth Extraction
Evaluation of Anesthetic Efficacy in Extraction on Mandibular Molars
To evaluate subjectively and objectively the quality and efficacy of local anesthetic block with mepivacaine in simple extraction of mandibular molar.
- Trial name
- NCT03106168
- Testing
- Extraction of mandibular molar
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Underdosing of Local Anesthetics, Anesthetics, Local
Determination of Minimum Effective Volume of Local Anesthetic in Patients Undergoing Ultrasound-Guided Infraclavicular Approach for Brachial Plexus Blockade
Peripheral nerve blocks with use of USG allowed visualisation of the structures and nerves and made the block administrations safe, quick and comfortable.
- Conditions
- Underdosing of Local Anesthetics, Anesthetics, Local, Peripheral Nervous System Agents, Physiological Effects of Drugs
- Trial name
- NCT03838120
- Testing
- Procedure/Surgery: bupivakain % 0,5
- Volunteers
- 48 people
- Sponsor
- Ankara City Hospital Bilkent
Third Molar
Trial to Evaluate the Efficacy on Local Anesthesia and Safety of 2% Lidocaine HCl With Different Epinephrine Concentration in Patients Undergoing Surgical Extraction of Impacted Lower Third Molars
This study is Phase 4 trial which evaluates the safety and efficacy of 2% Lidocaine HCl with different epinephrine concentration in patients undergoing surgical extraction of impacted lower third molars
- Trial name
- NCT02696369
- Testing
- 2% lidocaine HCl with epinephrine 1:200,000, 2% lidocaine HCl with epinephrine 1:80,000
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Huons Co., Ltd.
Drug Effect, Tooth Extraction
Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia
In the complexity of the Dental care the third molar surgery is one of the most common procedures, it is indicated for multiple reasons like infections in root canal, prosthetics or even esthetical purposes.
- Trial name
- ECA (NCT04166890)
- Testing
- Articaine / EPINEPHrine Cartridge
- Where
- Colombia
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Pain, Acute, Postoperative Pain
Quadratus Lumborum Block vs Erector Spinal Block for Post Abdomen Surgery Analgesia
Prior to surgery, patients will be stratified into groups according to the type of surgical procedure. The anticipated groups are as follows: Patients with colorectal cancer Patients with prostate cancer Patients with renal…
- Conditions
- Pain, Acute, Postoperative Pain, Anesthetics, Local
- Trial name
- NCT05446727
- Testing
- Ropivacaine injection
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Catheterization, Central Venous, Pain, Procedural
Comparison of Local Infiltration Anesthesia and Superficial Cervical Plexus Block in Ultrasound-Guided Internal Jugular Vein Catheterization: Efficacy, Duration, and Local Anesthetic Volume
Internal jugular vein (IJV) catheterization is a common invasive procedure performed under ultrasound (USG) guidance. Providing effective analgesia during the procedure is essential for patient comfort.
- Conditions
- Catheterization, Central Venous, Pain, Procedural, Internal Jugular Vein Cannulation
- Trial name
- NCT07841782
- Testing
- Lidocaine HCl 1%
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Kayseri City Hospital
Anesthesia
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0.5% lidocaine with 1:200,000 epinephrine…
- Trial name
- NCT00594542
- Testing
- lidocaine
- Volunteers
- 149 people
- Sponsor
- University of Pennsylvania
Pain Management, Local Anaesthesia
Effectiveness of DentalVibe in Reducing Injection Pain and Anxiety During Local Anaesthesia in Children
The aim of this study is to determine the effectiveness of DentalVibe (DV) in reducing injection pain and anxiety associated with local anaesthesia in paediatric patients.
- Trial name
- NCT03445182
- Testing
- Local anaesthesia with conventional syringe, Local anaesthesia with conventional syringe + Dentalvibe
- Where
- Bulgaria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Anesthesia, Local
Intraligamental Local Anesthesia Versus Infiltration Technique for Extraction of Grade II Mobility Maxillary Molars
The study aims to assess the use of intraligamental local anesthetic injection compared to buccal infiltration for extraction of maxillary molars suffering grade II mobility in terms of pain control and extraction duration.
- Trial name
- NCT05875350
- Testing
- Intraligamental local anesthetic injection
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Hand Surgery, Wrist Surgery
The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control.
- Conditions
- Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation
- Trial name
- NCT06806410
- Testing
- Liposomal bupivacaine (LB), Dexamethasone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Symptomatic Irreversible Pulpitis, Post Operative Pain
Effect of Preoperative Tramadol and Naproxen Sodium on Post Operative Pain
The goal of this clinical trial is to compare in Tramadol, Naproxen sodium and Placebo in participants presenting with irreversible pulpitis in their mandibular molar teeth.
- Trial name
- NCT05982392
- Testing
- Tramadol, Naproxen Sodium
- Where
- Pakistan
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Anesthesia, Anxiety
Buzzy Bee for Pain and Anxiety Control During Pediatric Dental Local Anesthesia
The present study will evaluate the effectiveness of Buzzy Bee in reducing pain and physiological responses during maxillary buccal infiltration in children aged 5-7 years compared with a conventional injection protocol.
- Conditions
- Anesthesia, Anxiety, Pain, Children
- Trial name
- NCT07886333
- Testing
- Intervention A: Buzzy® Bee-Assisted Local Anesthesia, Intervention B: Conventional Local Anesthesia Technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Wounds Injuries, Anesthesia, Local
Single-centre Study to Investigate Safety and Efficacy of Tri-Solfen in Wound Debridement
This is a Phase IIa open, randomised, single and parallel group, therapy controlled, single centre study, which has been divided into 3 sequential phases, which are designed to study respectively, (a) the time taken to achieve…
- Trial name
- NCT03865147
- Testing
- Tri-Solfen Gel (Lidocaine HCl, Bupivacaine HCl, Adrenaline Acid Tartrate /Cetrimide), EMLA cream, Post Operative Analgesia (Paracetamol, Ibuprofen)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Medical Ethics UK Ltd
Pain, Postoperative
Comparison of Different Local Anesthetic Dose in Suprascapular and Axillary Blocks in Shoulder Arthroscopies
The research is designed as a single-center, prospective, randomized double-blind study. The patients undergoing shoulder arthroscopy surgery in Istanbul University, Istanbul Faculty of Medicine, Department of Orthopedics and…
- Trial name
- NCT04947007
- Testing
- Bupivacaine hydrogen chloride (HCl) 0.025 % in 15+15 ML Injection, Bupivacaine HCl 0.025 % in 10+10 ML Injection, Bupivacaine HCl 0.025 % in 5+5 ML Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Istanbul University
Local Anesthesia, Analgesia
Catheter-over Needle: Outpatient Study
An alternative to general anesthesia - which puts a patient completely to sleep - is regional anesthesia, where local anesthetic is injected under the skin to freeze or 'block' a nerve or set of nerves.
- Trial name
- NCT01522066
- Testing
- Perineural catheter, Single-shot block
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Laparoscopic Sleeve Gastrectomy
Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Port-site Local Anesthetic Infiltration for Postoperative Analgesia and Pulmonary Function After Laparoscopic Sleeve Gastrectomy
Obesity poses severe global health risks and induces complex cardiorespiratory alterations, making perioperative care critical. For patients with morbid obesity, Laparoscopic Sleeve Gastrectomy (LSG) is the most effective…
- Trial name
- NCT07816055
- Testing
- Port-Site Local Anesthetic Infiltration, External Oblique Intercostal Block
- Volunteers
- 54 people
- Sponsor
- Assiut University