Clinical trials: Local Anesthetic Effectiveness
Abdominal Cancer, Abdominal Pain
Safety and Efficacy of Intrathecally Administered Magnesium Sulfate
Magnesium sulfate safety profile has been documented by histopathological analysis in experimental studies. magnesium sulfate added to local anesthetics decrease postoperative opioid requirements.
- Trial name
- NCT03459417
- Testing
- intrathecal morphine+LA, intrathecal morphine+LA+ Mg sulp. 50, intrathecal morphine+LA+ Mg sulp. 100
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- South Egypt Cancer Institute
Colorectal Neoplasms
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the…
- Trial name
- NCT00236249
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis
Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement
The purpose of this study is to examine three different ways to control pain after hip replacement: 1. One time injection of ropivacaine before wound closure 2.
- Trial name
- NCT01409278
- Testing
- Ropivacaine infiltration and saline infusion., Ropivacaine infiltration and infusion., Normal Saline
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Trinity Health Of New England
Drug Safety, Self Efficacy
Efficacy and Safety Study of Dexmedetomidine as an Additive to Local Anesthetics in Shoulder Surgery
The purpose of this study is to test the efficacy and safety of dexmedetomidine added to ropivacaine in patients undergoing shoulder surgery.
- Trial name
- NCT01557270
- Testing
- dexmedetomidine, saline
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Prof. Peter Gerner, M.D.
Patients With a Diagnosis of Odynophonia
Treatment Efficacy of Local Anesthetic/Steroid Mixture Injection for Patients With Odynophonia
This is a double-blind, randomized, placebo-controlled trial. A total of 40 subjects will be randomized to experimental group (receiving bupivacaine/triamcinolone mixture) or control group (receiving saline injection).
- Trial name
- NCT05178485
- Testing
- Bupivacain, Normal Saline
- Sponsor
- University of Texas Southwestern Medical Center
Post Operative Pain
Analgesic Efficacy of Genicular Nerve Block Versus (IPack Block ) in Patients Undergoing (ACL) Repair
One of the most common injuries to the knee is an anterior cruciate ligament (ACL) sprain or tear due to trauma ACL damage is crippling and often requires repair with an arthroscopic method, which is an outpatient surgery.
- Trial name
- NCT06404658
- Testing
- Genicular nerve block
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Analgesia
IPACK or Selective Tibial Nerve Block for ACL Reconstruction With an Adductor Canal Block
The purpose of this study is to compare the analgesic efficacy of the combination of an adductor canal and selective tibial nerve blocks versus adductor canal block and IPACK after ACL reconstruction under general anaesthesia.
- Trial name
- TIPACK (NCT05303233)
- Testing
- Selective tibial nerve block, IPACK
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cluneal Syndrome, Nerve Entrapment Syndrome
Study on the Efficacy of Infiltration of Upper Cluneal Nerves in Chronic Pain Related to Cluneal Syndrome
Lower back pain is a very common complaint in the Chronic Pain Clinic. Its etiology is nonspecific in 85% of the cases. In 1957, Strong and Davila reported that the superior cluneal nerves (SCNs) and middle cluneal nerves (MCNs)…
- Trial name
- NCT05423132
- Testing
- Ropivacaine injection, Physiological serum injection
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Postoperative Pain
Different Volumes of Local Anesthetics in Thoracolumbar Interfascial Plane Block
Ultrasound-guided thoracolumbar interfascial plane block (TLIP)was first described in 2015 by Hand et al which also target the dorsal rami of the thoracolumbar nerves as they pass through the paraspinal musculature(between the…
- Trial name
- NCT05276908
- Testing
- Thoracolumbar interfascial plane block (TLIP)Technique, Anesthetic Management, Bupivacaine Injection 10ml
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Diabetes Mellitus, Local Anesthesia
Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
The purpose of this study is to determine whether 2% lidocaine (L) + clonidine (C) (15 mcg/ml) as a vasoconstrictor achieves efficient (equal or better parameters of intraoral local anesthesia in comparison to 2% lidocaine +…
- Trial name
- LCIOADMT2 (NCT02371759)
- Testing
- L+C maxillary anesthesia, L+C mandibular anesthesia, L+E maxillary anesthesia
- Where
- Serbia
- Volunteers
- 256 people
- Sponsor
- University of Belgrade
Postoperative Pain
An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Undergoing Hysterectomy
The objective is to identify the optimal dose of SABER-Bupivacaine for postoperative pain control in patients undergoing hysterectomy on the basis of pharmacokinetics, efficacy and safety evaluations.
- Trial name
- NCT00993226
- Testing
- SABER-Bupivacaine Treatment 1a, Bupivacaine HCl Treatment 1c, SABER-Bupivacaine Treatment 2a
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 115 people
- Sponsor
- Durect
CHRONIC POST-TRAUMATIC NEUROPATHIC PAIN IN ANKLE AND FOOT
Pilot RCT of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Ankle and Foot Pain
Injections of local anesthetics (freezing) and steroids are often performed around injured nerves in individuals with nerve injury-related pain.
- Trial name
- PREPLANS (NCT02680548)
- Testing
- 0.9% saline, 0.25% bupivacaine hydrochloride injectable suspension USP, 4mg/cc methylprednisolone acetate injectable suspension USP
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University Health Network, Toronto
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to a lower molar, is more effective than a local anesthetic injection…
- Trial name
- NCT01862614
- Testing
- Articaine Hydrochloride + Epinephrine, Buffered Articaine Hydrochloride + Epinephrine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Anesthesia
The Effectiveness of the Addition of Dexmedetomidine to Analgesia for Ankle Surgery.
Forefoot surgeries involve a relatively short operation usually completed in 1 - 1½ hours, with patients generally being allowed to go home on the same day.
- Trial name
- NCT02170948
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Local Anesthesia
Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar Nerve Block
The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for anterior and middle superior alveolar nerve (AMSA)…
- Trial name
- NCT02440347
- Testing
- Computer controlled anesthetic delivery by Anaeject, Conventional anesthetic delivery by carpule syringe
- Where
- Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Gynecologic Laparoscopic Surgery, Postoperative Pain
"Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy"
This is a randomized, double-blind, controlled clinical trial evaluating the efficacy of local anesthetic (LA) in reducing postoperative pain in patients undergoing gynecologic laparoscopic surgery.
- Conditions
- Gynecologic Laparoscopic Surgery, Postoperative Pain, Recovery Outcomes, Pain Management
- Trial name
- NCT07030647
- Testing
- Bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Usama Ahmed Elsaeed Salem, MD
Local Anesthesia
Efficacy and Safety of Lambdalina (Lidocaine Cream) Versus Placebo as an Anesthetic for Laser Hair Removal
Double-blind, randomized, placebo-controlled trial to assess the efficacy of Lambdalina (lidocaine cream) in reducing pain associated with laser hair removal in women.
- Trial name
- NCT01360749
- Testing
- Lambdalina® (Lidocaine 4% cream)
- Where
- 2 sites in Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- ISDIN
Anesthesia, Local
Effective Use of Pecs and Transversus Thoracics Plane Blocks for Subcutaneous Cardiac Pacemaker Insertion: A Case Series
Participants that undergo permanent cardiac pacemaker implantation can often present with challenging anesthetic management plans for the anesthesia provider.
- Trial name
- NCT03899701
- Testing
- PEC I and PEC II blocks
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Osteoarthritis Knees Both
Efficacy of Corticosteroid and Local Anesthetic Injections Patients With Concomitant Pes Anserine Bursitis
To evaluate the efficiencies of local corticosteroid injections and local anesthetics in patients with concomitant pes anserine bursitis and osteoarthritis.
- Trial name
- NCT04887844
- Testing
- Lidocaine injection, Corticosteroid injection, Conventional Physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Abant Izzet Baysal University
Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia
Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia
The purpose of this study is to evaluate the effect of pH adjustment of the solution of articaine 4% with epinephrine 1:100.00, on the efficacy of anesthesia with the usage of a local anesthesia device that is needle-free…
- Trial name
- NCT07318311
- Testing
- Local anesthesia with articaine 4% with 1:100.000 epinephrine by using Comfort-in device, Local anesthesia with articaine 4% with 1:100.000 epinephrine with the addition of sodium bicarbonate 8,4% by using Comfort-in device
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki