Clinical trials: Local Disease
Endodontic Inflammation
Comparison of Osteocentral Versus Locoregional Anesthesia in Case of Mandibular Molar Pulpitis
The irreversible acute pulpitis is the most common emergency at the hospital during dental consultation. Pulpitis are characterized by intense and spontaneous oro-facial pains.
- Trial name
- COQ (NCT03802305)
- Testing
- computerized intraosseous technique (Quicksleeper™), loco-regional anesthesia (IANB technique)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Glaucoma
Effects of Common Topical Glaucoma Therapy on Optic Nerve Head Blood Flow Autoregulation During Increased Arterial Blood Pressure and Artificially Elevated Intraocular Pressure in Healthy Humans
Background Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve circulation has been shown in animals and…
- Trial name
- NCT00275756
- Testing
- Timolol (drug), dorzolamide (drug), brimonidine (drug)
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Acute Postoperative Pain
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of HYR-PB21 in Healthy Volunteers
This study is the first time into human study (FTIH) for HYR-PB21 for injection. The study will evaluate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending and single subcutaneous dose of HYR-PB21 for…
- Trial name
- NCT04169256
- Testing
- HYR-PB21, Liposomal bupivacaine, Normal Saline
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fruithy Medical Pty Ltd
Breast Neoplasm Female, Complication of Radiation Therapy
Delayed-immediate Versus Delayed Breast Reconstruction in Breast Cancer Patients With Mastectomy and Radiation Therapy
In breast cancer patients treated by mastectomy and adjuvant post-mastectomy radiation therapy (PMRT) reconstruction is often delayed until 6 - 12 month after completion of chemotherapy and PMRT, due to high risk of complication.
- Conditions
- Breast Neoplasm Female, Complication of Radiation Therapy, Breast Implant; Complications
- Trial name
- NCT03730922
- Testing
- Delayed-immediate reconstruction, Delayed reconstruction
- Where
- 8 sites in Denmark
- Volunteers
- 590 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Adenocarcinoma of the Pancreas, Locally Advanced
Ganitumab in Locally Advanced Unresectable Adenocarcinoma of the Pancreas
This study is a phase 2, multicenter, randomized, double-blind, active placebo-controlled trial of AMG 479 or placebo in combination with gemcitabine as first-line therapy for locally advanced unresectable adenocarinoma of the…
- Conditions
- Adenocarcinoma of the Pancreas, Locally Advanced, Unresectable
- Trial name
- NCT01318642
- Testing
- Gemcitabine, AMG 479
- Where
- 35 sites in United States, Austria and 11 more
- Volunteers
- 10 people
- Sponsor
- NantBioScience, Inc.
Resected Pancreatic Adenocarcinoma
Hyperthermia European Adjuvant Trial
Improvement of the clinical outcome in patients with resectable pancreatic carcinoma through an intensified adjuvant treatment with gemcitabine, cisplatin and regional deep hyperthermia as compared to standard chemotherapy.
- Trial name
- HEAT (NCT01077427)
- Testing
- Gemcitabine + Cisplatin + regional hyperthermia, Gemcitabine + Capecitabine
- Where
- Germany
- Volunteers
- 336 people
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Cat Allergy
Safety Evaluation of an Experimental Treatment, Intradermal Human Fcγ1-Fel d1 Fusion Protein (GFD), for Cat Allergy
The purpose of this trial is to show that Intradermal Human Fcγ1-Fel d1 fusion protein (GFD) is able to block the skin reaction to cat allergen in cat allergic subjects compared to the skin reaction to cat allergen alone.
- Trial name
- NCT01292070
- Testing
- Intradermal Human Fcγ1-Fel d1 fusion protein, Positive Control - standardized cat hair allergenic extract (CAT), Positive Control - Histamine Prick
- Where
- Australia
- Volunteers
- 4 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS)
Peripersonal Space Representation in Upper Limb Segmental Exclusion
This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects.
- Conditions
- Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS), Upper Limb Neglect (Peripheral)
- Trial name
- NCT07349173
- Testing
- Reachability Judgment Task in VR.
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Anesthetics, Local
EMLA Cream in Hysteroscopy Practice
The aim of this study is to investigate the efficacy of 5% lidocaine 25 mg-prilocaine 25 mg/g cream (EMLA®) applied to the uterine cervix for reducing pain during diagnostic hysteroscopy, using a visual analogue scale (VAS) for…
- Trial name
- NCT02640183
- Testing
- EMLA
- Volunteers
- 184 people
- Sponsor
- Ain Shams Maternity Hospital
Pulmonary Arterial Hypertension
Local Open-Label Access Study For Patients Who Completed A1481244 Study In Brazil
The purpose of this study is to provide sildenafil therapy to patients who completed the A1481244 study for the treatment of PAH, and reside in Brazilian States where Revatio™ is not supplied by Health Secretary, and are judged…
- Trial name
- NCT00866983
- Testing
- sildenafil (Revatio) 20 mg TID
- Where
- 2 sites in Brazil
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Knee Osteoarthritis
Ambulatory Continuous Adductor Canal Block to Facilitate Same Day Discharge Following Total Knee Arthroplasty: A Pilot Study
Patients scheduled to undergo total knee arthroplasty will receive motor sparing knee blocks with continuous adductor canal block along with multimodal analgesia started pre-operatively and continued into the postoperative…
- Trial name
- NCT02228759
- Testing
- Adductor canal block
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Preoperative radiotherapy combined with 5-fluorouracil/capecitabine is currently the standard treatment for locally advanced rectal cancer.
- Trial name
- ESTIMATE (NCT06239870)
- Testing
- Envafolimab combined with chemoradiotherapy in the whole course of neoadjuvant therapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Yunnan Cancer Hospital
Cardiac Disease
Incidence and Risk Factors for Persistent Post-sternotomy Pain After Cardiac Surgery in Local Chinese Population: a Prospective Cohort Study
CPSP is common after cardiac surgery. The reported incidence was 28% to 56% up to 2 years postoperatively. Despite a large number of cross-sectional and retrospective studies, prospective cohort studies examining the incidence of…
- Trial name
- NCT04644666
- Where
- Hong Kong
- Volunteers
- 220 people
- Sponsor
- Chinese University of Hong Kong
Epilepsy
Prospective Regional Epilepsy Database
PREDICT is an observational study following adults with an unprovoked seizure or epilepsy in the health care region of western Sweden.
- Trial name
- PREDICT (NCT04559919)
- Testing
- Seizure status, Tests, Epilepsy
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Sahlgrenska University Hospital
Anesthesia, Local
Evaluation of Efficacy of Intraligamentary Anesthesia for Mandibular Molar Extractions
Dental extraction is the most common procedure undertaken in the department of Oral Surgery, inferior alveolar nerve block (IANB), till today, is the most commonly used local anaesthesia technique for extraction of lower…
- Trial name
- NCT05122819
- Testing
- Mandibular Molar Extraction Under Local Anesthesia
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hamdard University
Ventral Hernia
Outpatient Repair of Small Reducible Ventral Hernias Using Local Anesthesia: A Pilot Study
Primary midline hernias, including umbilical and epigastric hernias, are prevalent surgical conditions, necessitating intervention.
- Trial name
- OPD-repair (NCT07514273)
- Testing
- Repair of small ventral hernia under lokal anesthesia, Hernia Repair, OPD Repair
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Region Örebro County
Molar Incisor Hypomineralisation
Articaine 4% Versus Lidocaine 2% for Local Anesthesia of MIH-affected Maxillary Molars
Comparison of injection pain with lidocaine and articaine. Comparison of the efficacy of lidocaine and articaine during treatment of MIH- maxillary molars.
- Trial name
- NCT05585112
- Testing
- Lidocaine 2%, Articaine 4%
- Where
- Syria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Latakia University
Diabetes, Anesthesia, Local
Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor
Evaluating the healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients
- Trial name
- NCT05875519
- Testing
- Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Minia University
Surgical Site Infection
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
The goal of this clinical trial is to evaluate whether local subcutaneous administration of gentamicin reduces the incidence of surgical site infection (SSI) following elective cesarean section.
- Trial name
- NCT07311395
- Testing
- Gentamicin, Standard antibiotic prophylaxis
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Shoulder-hand Syndrome
Acupuncture for Post-stroke Shoulder-hand Syndrome
Shoulder-hand syndrome，a common complication of stroke patient，which is an important factor of limb function recovery.This research aims to observe the effect and safety of Acupuncture and Traditional Chinese medicine Combined…
- Trial name
- NCT02011854
- Testing
- rehabilitation, Acupuncture
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zouqin Huang
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