Clinical trials: Local Disease
Healthy, Dermal Pharmacokinetic Measurement
An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques
This will be a single center, open label, exploratory research study to assess the dermal and systemic PK of marketed products of lidocaine/prilocaine in 26 healthy participants using dermal open flow microperfusion (dOFM) and…
- Trial name
- NCT03813030
- Testing
- Intravenous infusion of lidocaine, Lidocaine 2.5% and Prilocaine 2.5% cream", USP (2.5% lidocaine, 2.5% prilocaine, Actavis Pharma incorporated, USA), Lidocorit 2%-Ampullen" (Gebro Pharma Gesellschaft mit beschränkter Haftung, Austria)
- Where
- Austria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Joanneum Research Forschungsgesellschaft mbH
Breast Neoplasms, Radiotherapy
Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions
The goal of this trial is to evaluate the effect of the prone crawl treatment position and/or accelerated schedule on acute and late toxicities, as well as quality of life and time management for breast cancer patients receiving…
- Conditions
- Breast Neoplasms, Radiotherapy, Lymph Node Metastases
- Trial name
- PRO-SURF (NCT03280719)
- Testing
- Prone Radiotherapy, Acceleration, Supine Radiotherapy
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Ghent
Coronary Artery Disease
Local Thrombolytics Before Thrombectomy in STEMI
Background Prompt reperfusion with percutaneous coronary intervention (PCI) in the setting of ST-elevation myocardial infarction (STEMI) improves clinical outcomes through salvage of myocardial tissue.
- Trial name
- DISSOLUTION (NCT01568931)
- Testing
- Urokinase, Saline
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Lung Neoplasms, Non-Small Cell Lung Cancer
Osimertinib With or Without Primary Lung Tumor Resection for EGFR-Mutant Oligometastatic Non-Small Cell Lung Cancer
Osimertinib is a standard first-line treatment for patients with metastatic non-small cell lung cancer harboring an epidermal growth factor receptor exon 19 deletion or exon 21 L858R mutation.
- Trial name
- PTR-2 (NCT07738172)
- Testing
- Primary Tumor Resection, Osimertinib
- Where
- Taiwan
- Volunteers
- 154 people
- Sponsor
- National Taiwan University Hospital
Fatigue
Evaluation and Diagnosis of People With Pain and Fatigue Syndromes
This study will examine people who have pain or fatigue symptoms with a known or unknown diagnosis to determine eligibility for other research studies. No treatment is offered under this protocol.
- Trial name
- NCT00677157
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- National Institute of Nursing Research (NINR)
Lymphoma, B-Cell, Marginal Zone
Orelabrutinib Followed by Response-adapted Ultra-low Dose 4Gy Radiation as First-line Treatment of MALT Lymphoma
Investigate the efficacy and safety of Orelabrutinib followed by response-adapted ultra-low dose 4Gy radiation in the treatment of local-stage MALT lymphoma
- Trial name
- NCT06583837
- Testing
- Orelabrutinib, response-adapted radiation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fudan University
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Peripheral Arterial Disease
Local or Systemic Effects: Mechanisms Related to Arm Crank Exercise - Comparison Between Individuals With and Without PAD
INTRODUCTION: Exercise with an arm ergometer (EB) overcomes the main barrier to physical exercise in patients with Peripheral Artery Disease (PAD), leg pain during walking.
- Trial name
- NCT06828172
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Anesthesia
PENG Block vs. Intraoperative Local Anesthetic Infiltration for Total Hip Arthroplasty
Currently, the analgesic standard of care for patients undergoing total hip arthroplasty (THA) at our centre is intraoperative infiltration with a solution of local anesthetic, morphine (opioid), and ketorolac (nonsteroidal…
- Trial name
- NCT05898581
- Testing
- PENG Block, Control Group
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Rectal Cancer
Hyperthermia With Chemoradiotherapy in Rectal Cancer
The goal of this clinical trial is to evaluate the efficacy of deep regional hyperthermia in the context of radiochemotherapy followed by consolidation chemotherapy in locally advanced rectal cancer.
- Trial name
- ARO 2024-13 (NCT06831981)
- Testing
- Hyperthermia, Radiotherapy, Chemotherapy with 5-fluorouracil
- Where
- 2 sites in Germany
- Volunteers
- 264 people
- Sponsor
- University Hospital Tuebingen
Dental Implant Exposure Using Diode Laser
Using Diode Laser in 2nd Stage of Implant.
Dental Implants that are teeth replacements usually place with two stages. In the second stage the implant fixture, (which is the body that inserted in the bone is exposed to place the artificial tooth), is exposed using surgical…
- Trial name
- NCT06213467
- Testing
- diode laser 940nm
- Where
- Iraq
- Volunteers
- 15 people
- Sponsor
- University of Baghdad
Cerebral Palsy, Postoperative Pain
Combined Popliteal and Adductor Canal Blocks for Postoperative Analgesia in Children With Cerebral Palsy
This prospective, randomized, controlled trial aims to evaluate the postoperative analgesic efficacy of combined ultrasound-guided popliteal sciatic nerve block and adductor canal block in children with cerebral palsy undergoing…
- Trial name
- NCT07801365
- Testing
- Adductor Canal Block + Popliteal Sciatic Nerve Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Stroke
Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry
Controversy surrounds the use of regional cerebral oximetry (rSO2) as a measure of true cerebral oxygenation because of extracranial signal contamination and unmeasured confounding of cerebral a:v ratio.
- Trial name
- NCT03128957
- Testing
- IVOS cerebral oximeter, Licox cerebral oxygenation monitor, Cerebral oxygenation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Arrythmia
Assessment of Adverse Cardiac Events Using Local Anesthesia With Adrenaline
The use of vasopressor supplement materials to local anesthetics is commonly used in procedures in various fields of dentistry, ENT (ear, nose, and throat), Plastic Surgery, Hand surgery and gastroenterology.
- Trial name
- NCT02738567
- Testing
- patients undergoing surgery or medical procedure
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Rectal Cancer
Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer
This is a phase III randomized controlled trial comparing the efficacy and safety of FOLFOXIRI versus CapeOX as neoadjuvant regimen in treating patients with middle and upper locally advanced (MRI T3-4 or N+) rectal cancer.
- Trial name
- RCNAC (NCT05201430)
- Testing
- FOLFOXIRI, CapeOX
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Eosinophilic Esophagitis (EoE)
Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation
Eosinophilic esophagitis (EoE) is an allergic inflammation of the esophagus. If not treated properly, inflammation and narrowing of the esophagus can occur. This can eventually lead to food impaction.
- Trial name
- SINFONIA (NCT07012928)
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes Mellitus, Type 2
A Research Study Looking at How Victoza® Works in People With Type 2 Diabetes in Iran, Followed in Local Clinical Routine
The purpose of the study is to collect information on how the medicine Victoza® (liraglutide) works in people with Type 2 diabetes in Iran. Patients will get Victoza® as prescribed to them by their study doctor.
- Trial name
- VIEW-Iran (NCT03888157)
- Testing
- Liraglutide
- Where
- 16 sites in Iran
- Volunteers
- 839 people
- Sponsor
- Novo Nordisk A/S
Anxiety
Respiratory Biofeedback Device and Reduction of Dental Anxiety Associated With Local Anesthesia in Children
The aim of the study was to investigate the effect of a respiratory biofeedback device (RESPeRATE TM) in reduction of preoperative anxiety in children undergoing dental procedures under local anesthesia.
- Trial name
- NCT04238312
- Testing
- RESPeRATE™, Tell, Show and Do technique
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Nourhan M.Aly
Shoulder Pain , Laparoscopic Cholecystectomy
The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy has become the gold standard for the operative treatment of gallbladder disease due to its minimally invasive nature and improved patient outcomes.
- Trial name
- NCT07450781
- Testing
- Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic., Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight)., Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic.
- Where
- Egypt
- Volunteers
- 216 people
- Sponsor
- Alexandria University
Pain, Acute, Rib Fractures
Mid-point to Pleura Transverse Process Block Versus Thoracic Intervertebral Foramen Block
The analgesic effect of continuous mid-point to pleura transverse process block compared to the analgesic effect of continuous thoracic intervertebral foramen block, in patients with multiple rib fractures.
- Conditions
- Pain, Acute, Rib Fractures, Polytrauma
- Trial name
- NCT05348330
- Testing
- Thoracic intervertebral foramen block, Mid-point to pleura transverse process block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Salvatore Hospital of L'Aquila
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