Clinical trials: Local Disease
Underdosing of Local Anesthetics, Anesthetics, Local
Determination of Minimum Effective Volume of Local Anesthetic in Patients Undergoing Ultrasound-Guided Infraclavicular Approach for Brachial Plexus Blockade
Peripheral nerve blocks with use of USG allowed visualisation of the structures and nerves and made the block administrations safe, quick and comfortable.
- Conditions
- Underdosing of Local Anesthetics, Anesthetics, Local, Peripheral Nervous System Agents, Physiological Effects of Drugs
- Trial name
- NCT03838120
- Testing
- Procedure/Surgery: bupivakain % 0,5
- Volunteers
- 48 people
- Sponsor
- Ankara City Hospital Bilkent
Carpal Tunnel Syndrome
Medical Review: Hand Surgery After Local Block Versus Non-block
In this study, the effects of local block vs non block will be assessed with respect to postoperative outcomes (such as pain score, and recovery profiles) in outpatients after hand surgery.
- Trial name
- NCT01110759
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Aortic Stenosis Disease, TAVI(Transcatheter Aortic Valve Implantation)
Cerebral Regional Oxygen Saturation During TAVI - The CROS-TAVI Prospective Registry
This single-center, non-commercial clinical study investigates how different types of transcatheter aortic valve prostheses affect cerebral oxygen saturation during the procedure (TAVI - Transcatheter Aortic Valve Implantation).
- Conditions
- Aortic Stenosis Disease, TAVI(Transcatheter Aortic Valve Implantation), Cerebral Oxygen Saturation, Hemodynamic Changes
- Trial name
- CROS-TAVI (NCT07016789)
- Testing
- Near-infrared spectroscopy monitoring (NIRS) INVOS 5100C
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bladder Neoplasms
Mycobacterial Cell Wall-DNA Complex in Treatment of BCG-refractory Patients With Non-muscle Invasive Bladder Cancer
The purpose of this study is to determine the efficacy and safety of intravesical Mycobacterial Cell Wall-DNA Complex (MCC) in patients with non-muscle invasive transitional cell carcinoma (papillary tumors and/or carcinoma in…
- Trial name
- NCT00406068
- Testing
- Mycobacterial cell wall-DNA complex
- Where
- 31 sites in United States, Canada
- Volunteers
- 129 people
- Sponsor
- Bioniche Life Sciences Inc.
Bed Bathing
A Double-blind Evaluation of Adverse Effects of Bath With Wipes Impregnated With 2% Chlorhexidine Versus Placebo
Traditional bed bathing have been related to cross-infection. In order to avoid this complication, single-use products such as wipes impregnated with chlorhexidine use is increasing.
- Trial name
- NCT02096094
- Testing
- Standardization phase, Control bath, Bath with chlorhexidine
- Where
- Mexico
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Undernutrition, Healthy Nutrition
Women Supporting Women to Improve Infant and Child Feeding Practices
Undernutrition in the first 2 years of life is the largest preventable cause of death before age 5. Among those who survive, stunting before age two leaves millions with lifelong physical and cognitive deficits, which are…
- Conditions
- Undernutrition, Healthy Nutrition, Health Behavior, Health Knowledge, Attitudes, Practice
- Trial name
- NCT05473312
- Testing
- Community Sensitization, 28-day PD/Hearth Sessions, Supplemental Print Information
- Where
- Pakistan
- Volunteers
- 350 people
- Sponsor
- Aga Khan University
Quality of Recovery After Mastectomy, Serratus Anterior Plane Block
Timing of Serratus Anterior Plane Block in Mastectomy Surgery
Postoperative pain following mastectomy may adversely affect early mobilization, patient comfort, and overall quality of recovery.
- Conditions
- Quality of Recovery After Mastectomy, Serratus Anterior Plane Block, Postoperative Pain, Mastectomy
- Trial name
- NCT07661212
- Testing
- Ultrasound-Guided Serratus Anterior Plane Block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Atrial Septal Defect, Ventricular Septal Defect
Regional Anesthesia Following Pediatric Cardiac Surgery
The purpose of this study is to evaluate pain control following pediatric cardiac surgery with the use of local anesthesia via an ultrasound guided regional anesthetic technique compared with surgeon delivered wound infiltration.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
- Trial name
- NCT05688670
- Testing
- Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Duke University
Muscle-Invasive Bladder Carcinoma
NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment
Invasive bladder cancer is managed with neoadjuvant therapy followed by bladder removal (cystectomy). Research shows that approximately 40% of patient will have no remaining cancer left in their bladder after completion of the…
- Trial name
- NEO-BLAST (NCT06537154)
- Testing
- Active Surveillance, Control arm - Definitive bladder treatment
- Where
- Canada
- Volunteers
- 688 people
- Sponsor
- Peter Black
Prostatic Neoplasms
PSMA-PET and MRI for Detection of Recurrent Prostate Cancer After Radical Treatment
Approximately one third of prostate cancer patients experience biochemical relapse following initial radical prostatectomy or curative radiotherapy.
- Trial name
- NCT04298112
- Testing
- PSMA PET/CT, PSMA PET/MR
- Where
- 3 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Norwegian University of Science and Technology
Carpal Tunnel Syndrome, Anesthesia, Local
Ultrasound-guided Peripheral Nerve Block Versus Forearm Bier's Block in Patients Undergoing Carpal Tunnel Release
By means of an observer-blinded, randomized controlled trial, the analgesic efficacy of the forearm intravenous regional anesthesia and the ultrasound guided peripheral nerve block will be investigated in patients undergoing…
- Trial name
- NCT03411551
- Testing
- regional anesthesia
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Critical Illness, Lung Function Decreased
Effect of Early Mobilization on Regional Lung Ventilation Assessed by EIT
Changes in pulmonary ventilation and perfusion by EIT to out-of-bed activity in critically ill patients
- Conditions
- Critical Illness, Lung Function Decreased, ICU Acquired Weakness
- Trial name
- NCT04081129
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yun Long
Breast Neoplasms
Regional Anesthesia and Breast Cancer Recurrence
In this multi-center trial, Stage 1-3 patients having mastectomies or isolated lumpectomy with axillary node dissection will be randomly assigned to thoracic epidural or paravertebral anesthesia/analgesia, or to general…
- Trial name
- NCT00418457
- Testing
- General anesthesia and opioids, Regional analgesia and propofol
- Where
- 6 sites in United States, Austria and 4 more
- Volunteers
- 2,108 people
- Sponsor
- The Cleveland Clinic
Pseudo Angina, Myofascial Pain Syndromes
Treatment of Pectoralis Trigger Points in Patients With Pseudo Angina
Pseudo-angina is a musculoskeletal condition characterized by chest pain that resembles angina but occurs due to non-cardiac causes, particularly myofascial trigger points in the chest wall muscles.
- Conditions
- Pseudo Angina, Myofascial Pain Syndromes, Pectoralis Muscles, Musculoskeletal Chest Pain
- Trial name
- GT-LIC (NCT07728357)
- Testing
- Graston Technique, Local Ischemic Compression
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- University of Faisalabad
Pain
Use of Sedation and Local Anesthesia in Meatotomy: A Prospective Comparison Study
The aim of the study is to prospectively investigate the feasibility, pain control, and outcome of meatotomy performed under sedation and local anaesthesia compared with general anaesthesia with and without patient block
- Trial name
- NCT00480519
- Testing
- Meatotomy
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Rabin Medical Center
Low Back Pain
Integral Versus Local Movement Therapy Approach in Patients With Idiopathic Chronic Low Back Pain
Systematic reviews evaluating the effectiveness of supervised exercise therapies commonly conclude that, to date, there is no evidence to support the superiority of one form of exercise over another.
- Trial name
- NCT03623802
- Testing
- Local Movement Therapy, Integral Movement Therapy
- Where
- Slovenia
- Volunteers
- 80 people
- Sponsor
- University of Primorska
Breast Neoplasm Female
A Prospective, Open, Multicenter Single-arm Clinical Studie of Docetaxel, Carboplatin Combined With Inetetamab and Pyrotinib in the Treatment of Local-advanced HER2-positive Breast Cancer
This study is a prospective, open, multi-center, single arm trial. The treatment group will receive six cycles of docetaxel, carboplatin combined with Inetetamab and Pyrotinib before surgery.
- Trial name
- neoPICD (NCT06234137)
- Testing
- Docetaxel, Carboplatin, Inetetamab
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Wang Ouchen
Complex Regional Pain Syndrome Type I
Mirror Therapy in Complex Regional Pain Syndrome Type I
The aim is to evaluate the efficacy of Mirror Therapy on pain reduction and hand function in subjects with unilateral upper extremity Complex Regional Pain Syndrome Type I.
- Trial name
- NCT06100107
- Testing
- Mirror Therapy exercise
- Volunteers
- 27 people
- Sponsor
- University Hospital, Motol
Colorectal Neoplasms, Effects of Chemotherapy
Perioperative FOLFIRI VS Adjuvant FOLFIRI in Resectable Advanced CRC Failed to Oxaliplatin
Colorectal cancer (CRC) is one of the most leading causes of cancer death in China. Although multiple treatment modalities including surgery, radiotherapy and chemotherapy have been developed, the prognosis of advanced CRC still…
- Conditions
- Colorectal Neoplasms, Effects of Chemotherapy, Surgery, Metastasis
- Trial name
- NCT02087475
- Testing
- Irinotecan, 5-fluorouracil, Local radiotherapy
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Local Registration Trial in China Humalog Mix 50
The primary objective of this study is to compare the 2-hour PPBG excursion following a standard test meal in insulin-requiring diabetic patients treated twice daily with human insulin mix 50/50, versus the 2-hour PPBG excursion…
- Trial name
- NCT00191581
- Testing
- Humalog Mix 50, Human Insulin Mix 50:50
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
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