Clinical trials: Local Disease
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Preoperative radiotherapy combined with 5-fluorouracil/capecitabine is currently the standard treatment for locally advanced rectal cancer.
- Trial name
- ESTIMATE (NCT06239870)
- Testing
- Envafolimab combined with chemoradiotherapy in the whole course of neoadjuvant therapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Yunnan Cancer Hospital
Pleural Effusion, Malignant, Pleural Effusion
A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.
Pleural fluid can be caused by cancer. Patients with repeated presentation of pleural fluid where initial diagnostic tests have been inconclusive are the focus of this trial.
- Conditions
- Pleural Effusion, Malignant, Pleural Effusion, Pleura; Exudate
- Trial name
- NCT04233359
- Testing
- Local anesthetic thoracoscopy, US-guided pleural biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 4 people
- Sponsor
- Naestved Hospital
Neck Pain, Chronic Pain
The NEXERCISE-trial: Reshaping Exercise Programs for Patients With Non-specific Neck Pain
The Nexercise-trial is a blended treatment program for patients with chronic non-specific neck pain. We will investigate whether a blended treatment approach, combining specific neck exercises and general aerobic exercises, has…
- Trial name
- NEXERCISE (NCT04749823)
- Testing
- Blended treatment program, Specific strength exercise program, General aerobic exercise program
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University Ghent
Fibromyalgia, Complex Regional Pain Syndromes
Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain
Study investigating the potential benefit for chronic pain patients (CRPS and FM) using low-intensity focused ultrasound for neuromodulation.
- Conditions
- Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain
- Trial name
- NCT05751096
- Testing
- Low-intensity Focused Ultrasound (LIFU)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Carilion Clinic
Tranexamic Acid, Fibrinolysis
Anti-fibrinolytic and Anti-inflammatory Effects of Local Infiltration of Tranexamic Acid in Patients With Calcaneal Fractures
Background. Consensus is lacking regarding the use of tranexamic acid (TXA) in calcaneal fracture surgery. This study aims to investigate the hypothesis that local infiltration of TXA in the post-operation would maintain…
- Conditions
- Tranexamic Acid, Fibrinolysis, Inflammatory, Fracture
- Trial name
- NCT05598086
- Testing
- Tranexamic acid
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Hebei Medical University Third Hospital
Neuroblastoma
Local Control With Reduced-dose Radiotherapy for High-Risk Neuroblastoma
The purpose of this study is to give 12T a smaller dose of radiation in order to decrease these late side effects.
- Trial name
- NCT02245997
- Testing
- External beam radiotherapy, proton beam RT
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain, Radiculopathy, Cervical
Analysis of Spread Level During Thoracic Erector Spinae Block
The primary purpose of this study was to identify the ESPB spread level in the craniocaudal direction when performed at the T2 level.
- Trial name
- NCT05082220
- Testing
- Erector spinae plane block
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Keimyung University Dongsan Medical Center
Inguinal Hernia
The Addition of Hydromorphone to Local Anesthetics for the Repair of Inguinal Hernias in Elderly Patients
To compare the clinical and postoperative analgesic effects of hydromorphone combined with ropivacaine and ropivacaine alone in quadrangular muscle block for open inguinal hernia in elderly patients.
- Trial name
- NCT06218160
- Testing
- Hydromorphone combined with ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Second Hospital of Jilin University
Anesthesia
Comparison of Articaine Mandibular Infiltration to Lidocaine Inferior Alveolar Nerve Block in Pediatric Patients
This is a prospective, single-blind, parallel-design randomized controlled clinical trial that aims compare the effectiveness of articaine local infiltration to lidocaine inferior alveolar nerve block (IANB) for restorative…
- Trial name
- NCT04865848
- Testing
- Dental local anesthesia
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cholestasis
Inter-regional Cohort of Neonatal and Infant Cholestasis in the Greater Southwest Region
The goal of the study is to characterize the epidemiologic data of the neonatal and infant cholestasis.
- Trial name
- CHOLESTASE (NCT02767648)
- Testing
- proteomic urine analysis
- Where
- 4 sites in France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Toulouse
Traumatic Brain Injury, Coma
Optimized Therapy in Severe Traumatic Brain Injured Patients
Severe traumatic brain injury is associated with life-threatening and incapacitating secondary injury. Contemporary therapeutic interventions are aimed at preventing and treating secondary damage.
- Trial name
- NCT02130674
- Testing
- Dipeptiven
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Colorectal Cancer, Lymph Node Metastases
Use of Plasma ctDNA Methylation Haplotypes in Detecting Local Residual or Lymph Node Metastasis
This is a prospective, clinical study. This study is to evaluate the sensitivity of plasma ctDNA methylation haplotypes in detecting local residual or lymph node metastasis.
- Trial name
- NCT03868215
- Testing
- Next-generation sequencing (NGS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Plantar Fascitis, Tibial Nerve
Ultrasound-Guided Tibial Nerve Block vs. Local Corticosteroid Injection in Recalcitrant Plantar Fasciitis Treatment
A randomized controlled study to search for the efficiency of tibial nerve block vs local corticosteroid injection of the plantar fascia.
- Conditions
- Plantar Fascitis, Tibial Nerve, Injections, Ultrasonography
- Trial name
- NCT04029389
- Testing
- Injection, Tibial nerve block, Conservational therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Anesthesia, Local
Comparing Local Anesthetic Techniques for Clavicular Surgeries
Surgical fixation for acute clavicular fractures is increasingly preferred among orthopedic surgeons to improve healing and decrease the risk of malunion.
- Trial name
- NCT06220591
- Testing
- Superior trunk block, Clavipectoral fascial plane block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Pain, Postoperative
Efficacy of Bupivacain Local Infiltration for the Management of Pain During Cesarean Section
This study aims to evaluate the effect of local administration of bupivacain in the cesarean section incision for postoperative pain control, using the visual analogue pain scale (VAS) and assessing the need for rescue analgesia…
- Trial name
- NCT05404490
- Testing
- Bupivacain
- Where
- Panama
- Volunteers
- 202 people
- Sponsor
- Saint Thomas Hospital, Panama
Saphenous Vein Injury
Patient Satisfaction, Safety, and Efficacy of Endovenous Laser Treatment for Saphenous Veins and Varicose Veins
The purpose of this study is to evaluate the post-operative patient satisfaction on the treatment of saphenous veins and varicose veins outside the operating theater under strict local anesthesia with a 1940 nm laser via the…
- Trial name
- IPV-1940 (NCT07629843)
- Testing
- Endovenous laser ablation of the primary or recurrent saphenous vein
- Where
- 2 sites in France
- Volunteers
- 155 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Colorectal Neoplasms
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the…
- Trial name
- NCT00236249
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pain, Chronic Pain
ERECTOR SPINE PLANE BLOCK VERSUS LOCAL INFILTRATION ANAESTHESIA FOR TRANSFORAMINAL PERCUTANEOUS ENDOSCOPIC DISCECTOMY
The main aim of our study was to test the hypothesis that Erector spine plane block (ESP) with sedation will provide the similar employment of fentanyl and propofol during surgery as an infiltrative local anaesthesia with…
- Conditions
- Acute Pain, Chronic Pain, Postoperative Pain, Anesthesia
- Trial name
- NCT05483647
- Testing
- Local infiltrative anaesthesia, Erector spine plane block
- Where
- Ukraine
- Volunteers
- 52 people
- Sponsor
- Lviv National Medical University
Gynecologic Laparoscopic Surgery, Postoperative Pain
"Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy"
This is a randomized, double-blind, controlled clinical trial evaluating the efficacy of local anesthetic (LA) in reducing postoperative pain in patients undergoing gynecologic laparoscopic surgery.
- Conditions
- Gynecologic Laparoscopic Surgery, Postoperative Pain, Recovery Outcomes, Pain Management
- Trial name
- NCT07030647
- Testing
- Bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Usama Ahmed Elsaeed Salem, MD
Prostate Cancer
MRI-guided Ultrahypofractionated SBRT Prostate Program
The goal of this clinical trial is to learn if the use of MRI-guided asymmetric ultrahipofractionated irradiation (2 fractions with dose increase in the tumor areas and dose sparing in urethra, rectum and neurovascular bundles)…
- Trial name
- NCT07132658
- Testing
- MR-Guided SBRT
- Volunteers
- 40 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
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