Clinical trials: Local Disease
Locally Advanced Cervical Cancer
Study of Chemoradiotherapy With Envafolimab For The Treatment of Locally Advanced Cervical Cancer
This is a single-arm, single-center, exploratory study, the purpose of this study is to evaluate the efficacy and safety of envafolimab combined with Chemoradiotherapy in participants with locally advanced cervical cancer.
- Trial name
- NCT05799469
- Testing
- Envafolimab, Cisplatin, External Beam Radiotherapy (EBRT)
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chongqing University Cancer Hospital
Abortion, Induced, Pain
Paracervical Versus Intracervical Lidocaine
The aim of this study is to estimate the efficacy of intracervical versus paracervical block on pain experienced during first trimester suction curettage without the use of preoperative cervical ripening.
- Trial name
- NCT00816751
- Testing
- Paracervical block, Intracervical, Buffered Lidocaine, vasopressin, sodium bicarbonate
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Crohn Disease
An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF
Crohn's disease is a chronic inflammation of all or part of the digestive tract, " from the mouth to the anus ". . Cell therapy is a new and promising approach for the treatment of inflammatory disease including Crohn's disease…
- Trial name
- NCT02520843
- Testing
- stromal vascular fraction (SVF)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
HNSCC
Trial Combining Pembrolizumab and Cesium 131 Brachytherapy With Salvage Surgery in HNSCC
To Study Perioperative PD-1 Inhibitor and Cesium-131 Interstitial Brachytherapy in patients with locally recurrent HNSCC eligible for salvage surgery.
- Trial name
- NCT04340258
- Testing
- Cesium-131, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Oral Mucositis in Head and Neck Cancer
Propolis for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer
This clinical trial evaluated whether a 15% propolis solution could delay or prevent severe oral mucositis in patients with head and neck cancer receiving radiotherapy or concurrent chemoradiotherapy.
- Trial name
- NCT07597525
- Testing
- 15% Propolis solution, Standard oral care
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara Oncology Research and Training Hospital
Pain, Acute, Analgesia
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain…
- Conditions
- Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder
- Trial name
- NCT04057989
- Testing
- ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Venipuncture, Healthy Adult
Clinical Trial to Assess the Effectiveness of Applying Dry Local Heat and/ or High Tourniquet Pressure for Venipuncture.
Low level intervention health products clinical trial, fourth phase, non-commercial research. Dissertation of COMPLUTENSE UNIVERSITY of Madrid. Principal Investigator of this clinical trial: Ms.
- Trial name
- ECYPVEN-H/17 (NCT04027218)
- Testing
- Dry heat, High pressure, Combination of dry heat and high pressure
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Intranasal Dexmedetomidine Breast Cancer Local Anaesthesia
Efficacy and Optimal Dose Selection of Intranasal Dexmedetomidine During Breast Lumpectomy Under Local Anaesthesia
This trial is going to evaluate the safety and effectiveness of intranasal DEX(dexmedetomidine) in breast lumpectomy under local anaesthesia,and to investigate the optimal dose of intranasal DEX in breast lumpectomy.
- Trial name
- NCT02675049
- Testing
- 0.9% saline, dexmedetomidine 1µg.kg-1, dexmedetomidine 1.5µg.kg-1
- Volunteers
- 100 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
PARKINSON DISEASE (Disorder)
Description of the Reasons for Hospitalization of Patients With Parkinson's Disease Following Admission Through the Adult Emergency Department
The goal of this observational study is to investigate the causes of hospitalisation via emergency services in patients with degenerative parkinsonian syndromes.
- Trial name
- Emerge Park (NCT07439926)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 2,580 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastrin-Producing Neuroendocrine Tumor, Lung Carcinoid Tumor
Cixutumumab, Everolimus, and Octreotide Acetate in Treating Patients With Advanced Low to Intermediate Grade Neuroendocrine Carcinoma
This phase I trial studies the side effects and best dose of cixutumumab when given together with everolimus and octreotide acetate in treating patients with advanced low- or intermediate-grade neuroendocrine cancer.
- Conditions
- Gastrin-Producing Neuroendocrine Tumor, Lung Carcinoid Tumor, Metastatic Digestive System Neuroendocrine Tumor G1, Pancreatic Glucagonoma
- Trial name
- NCT01204476
- Testing
- Cixutumumab, Everolimus, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer, PD-L1
Immune Profiling After HDR in Local Relapsed Prostate Cancer
Immunotherapy is currently revolutionizing the field in oncology. However, prostate cancer until now fails to respond to classical IO, like PD-1 and CTLA-4 inhibitors.
- Trial name
- PRIMUS (NCT04247217)
- Testing
- HDR salvage brachytherapy
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Chronic Renal Failure of Unknown Cause
CKDu Treated With Intra-arterial Infusion of Autologous SVF Cells
This is an interventional study to treat 18 patients with chronic kidney disease of unknown cause (CKDu), formerly known as Mesoamerican nephropathy (MeN), with autologous adipose tissue-derived stromal vascular fraction (SVF)…
- Trial name
- NCT05154591
- Testing
- Adipose-derived stromal vascular fraction cells
- Where
- Nicaragua
- Volunteers
- 18 people
- Sponsor
- Samuel Vilchez, PhD
Non-small Cell Lung Cancer
Analysis of Driver Gene Mutation in Early Stage Non-small Cell Lung Cancer
Analysis of driver gene variation in early stage non-small cell lung cancer
- Trial name
- NCT04266691
- Testing
- nonIntervention
- Volunteers
- 237 people
- Sponsor
- Zhejiang Cancer Hospital
Surgical Site Infection (SSI)
Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic
Surgical site infections were defined as infections that developed in the area of an operation within 30 days after surgery. They remained a common problem after surgery and could increase pain, delay wound healing, prolong…
- Trial name
- NCT07478874
- Testing
- Cefazolin plus Gentamicin, Cefazolin
- Where
- Pakistan
- Volunteers
- 284 people
- Sponsor
- Lahore General Hospital
Overactive Bladder
Local Anesthetic Treatments for Overactive Bladder
The purpose of this study is to determine whether alkalized lidocaine instilled into the bladder is effective in the treatment of overactive bladder (OAB).
- Trial name
- NCT00427648
- Testing
- alkalinized xylocaine
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Frank Tu
Postoperative Pain
Different Volumes of Local Anesthetics in Thoracolumbar Interfascial Plane Block
Ultrasound-guided thoracolumbar interfascial plane block (TLIP)was first described in 2015 by Hand et al which also target the dorsal rami of the thoracolumbar nerves as they pass through the paraspinal musculature(between the…
- Trial name
- NCT05276908
- Testing
- Thoracolumbar interfascial plane block (TLIP)Technique, Anesthetic Management, Bupivacaine Injection 10ml
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Analgesia
Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery
The enhanced recovery anesthesia concept has been widely adopted, including cesarean delivery. Modern obstetrical anesthesia aims to offer an experience to a patient undergoing a cesarean delivery similar to normal vaginal…
- Trial name
- NCT05042817
- Testing
- 100 mcg morphine, 0.9% NaCl, 50 mg prilocaine + 2.5 mcg sufentanil
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University of Liege
Breast Cancer
Ultrasound Paravertebral Block in Breast Surgery.
The purpouse of the study is to determine wether Ultrasound Guided,Ens-assisted paravertebral block with single shot is a safe and reliable anesthetic technique in breast surgery.
- Trial name
- NCT01818817
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Campus Bio-Medico University
Pancreas, Cancer
Magnetic Resonance-guided High-intensity Focused Ultrasound Treatment of Locally Advanced Pancreatic Cancer
Patients with unresectable pancreatic cancer in most of cases cannot benefit from percutaneous ablation modalities, due to high risk of procedure-related complications.
- Conditions
- Pancreas, Cancer, Locally Advanced Pancreatic Cancer, Non-invasive Treatment
- Trial name
- NCT01786850
- Testing
- Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)
- Where
- Italy
- Sponsor
- University of Roma La Sapienza
Invitro Fertilization
Endometrial Injury and Implantation Rates Before First ICSI Cycle
Midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix, the step that will be beneficial…
- Trial name
- NCT02660125
- Testing
- Endometrial scratch injury
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
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