Clinical trials: Local Disease
Wound Heal, Scar; Previous Cesarean Section
Role of Local Skin Incision Infiltration by Oxytocin On Wound Healing
caesarean section rate in Egypt has reached about 60% between primgravidae. Wound complications are of the most common morbidities following cesarean section.
- Trial name
- NCT05745935
- Testing
- Oxytocin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Egymedicalpedia
Dexmedetomidine, Quadratus Lumborum Block
Impact of Adding Dexmedetomidine as an Adjuvant to The Local Anesthetic in Quadratus Lumborum Block in Patient Undergoing Caesarean Section
The goal of this clinical trial is to evaluate the effects of adding Dexmedetomidine to local anesthetic agent (bupivacaine) for quadratus lumborum block (QLB) after spinal anesthesia in patient undergoing elective caesarean…
- Conditions
- Dexmedetomidine, Quadratus Lumborum Block, Postoperative Analgesia, Caesarean Section
- Trial name
- NCT07072650
- Testing
- Dexmedetomidine
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Majid Fakhir Mutar Alhamaaidah
Cholangiocarcinoma
A Phase I/II Safety and Efficacy Study of PCI of Gemcitabine and Chemotherapy in Patients With Cholangiocarcinomas
This is a Phase I Dose Escalation Study in which the safety, tolerability and efficacy of Amphinex®--induced Photochemical Internalisation (PCI) of Gemcitabine followed by Gemcitabine/Cisplatin Chemotherapy will be assessed in…
- Trial name
- NCT01900158
- Testing
- Amphinex, Gemcitabine and Cisplatin
- Where
- 11 sites in France, Germany and 2 more
- Volunteers
- 24 people
- Sponsor
- PCI Biotech AS
Lumbar Disc Herniation
Lumbar Epidural Analgesia Versus Local Anesthesia With Dexmedetomidine Infusion in Endoscopic Lumbar Discectomy
To compare between local anesthesia combined with intravenous Dexmedetomidine and epidural analgesia as regard the effectiveness and patient satisfaction during percutaneous transforaminal endoscopic discectomy.
- Trial name
- NCT05850455
- Testing
- Dexmedetomidine Hydrochloride 'Precedex' combined with, Lumbar epidural analgesia with Bupivacaine 0.25% 'Sunnypivacaine', General anesthesia
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Breast Cancer, Pain, Acute
ESP in Breast Surgery Due to Cancer
Patients scheduled for breast surgery due to cancer. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Conditions
- Breast Cancer, Pain, Acute, Anesthesia, Local
- Trial name
- NCT04726878
- Testing
- Erector spinae plane block, General anesthesia, Patient-controlled analgesia
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Medical University of Lublin
Cervical Radiculopathy
Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?
"Does low-does cervical epidural lidocaine cause transient weakness?"
- Trial name
- NCT03382925
- Testing
- cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Wound Healing
Manuka Honey for Wound Care
Since antiquity, honey has been recognized for its healing properties. Literature about the use of medicinal honey for wound care dates back centuries with recent data suggesting its use in patients suffering from burns or…
- Trial name
- NCT02259491
- Testing
- Manuka Honey Dressing
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Muscular Atrophy
Longitudinal Data Collection in Pediatric and Adult Patients With Spinal Muscular Atrophy in Latin America
The natural history of SMA patients has changed, due to the improvements in treatment and technological advances. The systematic collection of data from routine clinical practice in multiple Latin American countries, harmonized…
- Trial name
- RegistrAME (NCT05475691)
- Where
- 18 sites in Argentina, Brazil and 4 more
- Volunteers
- 361 people
- Sponsor
- Hospital Israelita Albert Einstein
Bronchiolitis
Organizational Infrastructure Pediatric Plan in Bronchiolitis Epidemics
Acute bronchiolitis is a frequent respiratory viral infection of infants, responsible for 460,000 new cases per year in France. Over the years, the number of hospitalizations during the epidemic season appears to be increasing.
- Trial name
- OIPP (NCT03663660)
- Testing
- Organizational infrastructure pediatric plan (OIPP)
- Where
- France
- Volunteers
- 1,636 people
- Sponsor
- University Hospital, Montpellier
Assessing the Effect of Acupoint Massage on Pain and Anxiety in Patients Undergoing Surgery Under Local Anesthesia
The Effectiveness of Acupressure on the Physiological and Psychological Improvement of Patients Undergoing Local Anesthesia
Background: Local anaesthesia surgeries are outpatient procedures that allow patients to go home the same day. However, these surgeries often cause pain and anxiety for patients.
- Trial name
- LA (NCT06681519)
- Testing
- Experimental Group 1 - Acupoint Pressure Experimental Group 2 - Pressure Ball Control Group - Conventional Treatment
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Yu-Jui Feng
Epistaxis
The Efficacy of Local Application of B-sitosterol Versus Vasline in Cases of Idiopathic Epistaxis
Epistaxis, commonly known as nosebleed, is a frequent otorhinolaryngological complaint, affecting a large proportion of the population.
- Trial name
- NCT07511192
- Testing
- vasline, B-sitosterol
- Volunteers
- 162 people
- Sponsor
- Assiut University
Dental Anxiety, Dental Fear
The Effect of a Kaleidoscope and Cartoons for Dental Treatment in Children
Dental fear and anxiety are among the most common challenges encountered in pediatric dental practice and may negatively affect children's cooperation and acceptance of dental treatment.
- Conditions
- Dental Anxiety, Dental Fear, Pain
- Trial name
- Pain (NCT07462364)
- Testing
- Kaleidoscope Distraction, Cartoon Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Dicle University
Analgesia
Comparing QLB Type I Block to Intraperitoneal Instillation Added to Wound Infiltration for Postoperative Cesarian Pain
This study aimed to compare the efficacy of local anaesthetic infiltration into all layers of the anterior abdominal wall with peritoneal instillation and QLB type I for pain reduction in women undergoing elective cesarean…
- Trial name
- NCT06129032
- Testing
- Wound infiltration (LWI) + Intraperitoneal local anaesthetic (IPLA) instillation, Group QUADRATUS LUMBORUM BLOCK (QLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Knee Osteoarthritis, Knee Rheumatism
Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?
One common anesthetic that is performed for total knee replacement surgery is spinal anesthesia with an adductor canal regional block, which involves injecting numbing medication in the thigh region for pain control after…
- Trial name
- NCT03326999
- Testing
- Obturator nerve regional block, Adductor canal regional block, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Multiple Sclerosis
A Multi-center, Multi-regional Observational Study to Test the Responsiveness of the Validated MusiQoL (Multiple Sclerosis International Quality of Life Questionnaire) Instrument to EDSS Status Changes in Any Form of Multiple Sclerosis (MS) in Patients With or Without Treatment
This is a multi-center, multi-regional observational,24 month study. Health-related quality of life data from the MusiQoL instrument and SF-36 instrument will be collected at baseline, M6, M12, M18 and M24 in patients with MS.
- Trial name
- MusiQoL (NCT00702065)
- Where
- 30 sites in United States, Argentina and 10 more
- Volunteers
- 599 people
- Sponsor
- EMD Serono
Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma
TLR9 Agonist SD-101, Ibrutinib, and Radiation Therapy in Treating Patients With Relapsed or Refractory Grade 1-3A Follicular Lymphoma
This phase Ib/II trial studies the side effects and best dose of toll-like receptor 9 (TLR9) agonist SD-101 when given together with ibrutinib and radiation therapy and to see how well they work in treating patients with Low…
- Conditions
- Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma, Grade 3a Follicular Lymphoma, Recurrent Follicular Lymphoma
- Trial name
- NCT02927964
- Testing
- Ibrutinib, Radiation Therapy, TLR9 Agonist SD-101
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Robert Lowsky
Dermatitis
Olive Oil With Omega 3 to Treat Stasis Dermatitis
Olive oil and Omega 3 have many anti inflammatory effects that may be beneficial in the inflammation and edema of chronic stasis dermatitis.
- Trial name
- NCT00421161
- Testing
- olive oil and omega 3 in a combined cream
- Where
- 3 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Combination Chemotherapy in Treating Patients With Advanced Bladder or Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003342
- Testing
- filgrastim, carboplatin, doxorubicin hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Methemoglobinemia
Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
To establish and compare maximum methemoglobin blood levels and times to maximum methemoglobin blood levels following the administration of the injectable local anesthetics prilocaine and lidocaine when used for dental treatment…
- Trial name
- NCT01402869
- Testing
- 4% prilocaine plain, 2% Lidocaine with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Non-small Cell Lung Cancer
Study of Concurrent Chemo-radiotherapy Combined With Recombinant Human Endostatin for Local Advanced Non-small Cell Lung Cancer (NSCLC)
It is a trials to evaluate the overall survival (OS) of radiotherapy / EP combined with recombinant human endostatin in treatment of locally advanced (Ⅲ A / unresectable Ⅲ B) non-small cell lung cancer.
- Trial name
- NCT01211002
- Testing
- radiotherapy combined with EP, radiotherapy / EP combined with recombinant human endostatin
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Simcere Pharmaceutical Co., Ltd
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