Clinical trials: Local Disease
Pain, Needle Phobia
Pain Perception of Needle-free System
The purpose of this study is to evaluate and compare the pain perception associated with a needle-free injection system( Comfort-In) and dental injection method in filling and pulpotomy treatments
- Conditions
- Pain, Needle Phobia, Anxiety, Dental Fear
- Trial name
- NCT04653974
- Testing
- Needle-free injection
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis)
Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance
This study collects data from patients undergoing minimally invasive, image-guided cancer treatments at participating hospitals in the Netherlands and France.
- Conditions
- Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis), Bone Cancer Metastatic, Bone Cancer Tumor
- Trial name
- PreciseOnco (NCT07636148)
- Where
- 3 sites in France, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Mark C Burgmans, MD PhD
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery
The study aims to test the safety and effectiveness of two different surgeon-administered methods of the anesthesia medication EXPAREL during knee replacement surgery.
- Trial name
- CRS-121 (NCT07584915)
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Contraception, IUD
Uterovaginal Plexus Block With Articaine for Intrauterine Device Placement Patients Who Are Indicated for the Use of Copper IUD as a Contraceptive Method Will be Invited to Participate in This Research.
The use of intrauterine device (IUD) in Brazil is still not very significant and one of the reasons is the fear of feeling pain during its insertion procedure.
- Conditions
- Contraception, IUD, Anesthesia, Local
- Trial name
- NCT05252117
- Testing
- Articaine Hydrochloride 40 MG/ML, Mepivacaine
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Vaginal Hysterectomy
Liposomal Bupivacaine in Vaginal Hysterectomy
The aim of this study is to compare the effects of preemptive analgesia using liposomal bupivacaine mixed with bupivacaine HCl, versus bupivacaine HCl alone for uterosacral ligament injection in patients undergoing vaginal…
- Trial name
- NCT03907033
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Lumbar Disc Herniation
Lumbar Epidural Analgesia Versus Local Anesthesia With Dexmedetomidine Infusion in Endoscopic Lumbar Discectomy
To compare between local anesthesia combined with intravenous Dexmedetomidine and epidural analgesia as regard the effectiveness and patient satisfaction during percutaneous transforaminal endoscopic discectomy.
- Trial name
- NCT05850455
- Testing
- Dexmedetomidine Hydrochloride 'Precedex' combined with, Lumbar epidural analgesia with Bupivacaine 0.25% 'Sunnypivacaine', General anesthesia
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Osteoporotic Vertebral Compression Fracture
Unilateral Versus Bilateral Vertebroplasty in Local Anaesthesia
Osteoporotic vertebral compression fractures are a common cause of severe back pain and disability in elderly patients. Percutaneous vertebroplasty (PVP) with polymethylmethacrylate (PMMA) cement is widely used to relieve pain…
- Trial name
- UNI-BI PVP (NCT07198776)
- Testing
- Percutaneous Vertebroplasty
- Where
- Slovenia
- Volunteers
- 196 people
- Sponsor
- Igor Movrin
Complex Regional Pain Syndrome
Light Irradiation and Outcome for Neuropathic Pain
Background. Sympathetically maintained pain (SMP) can be effectively relieved by light irradiation to the area near stellate ganglion (SGI), which is applied as an alternative to sympathetic blockade.
- Trial name
- NCT03228160
- Testing
- Linearly Polarized Near-Infrared light Irradiation
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Analgesia, Epidural
Levobupivacaine for Epidural Analgesia in Labour
In a prospective randomised study involving primiparous women in spontaneous uncomplicated labour with cervical dilatation > 7 cm, epidural analgesia will be given with an initial volume of 20 mL anaesthetic solution, followed by…
- Trial name
- NCT00929682
- Testing
- Randomization between two referenced treatments
- Volunteers
- 136 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Kidney Diseases
Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?
This study aims at evaluating, in chronic kidney disease patients on dialysis, the effect of acute per- or pre-dialytic physical exercise on regional myocardial function and myocardial stunning, blood viscosity, arterial…
- Trial name
- EXP DIAL (NCT04831021)
- Testing
- Dialysis without physical exercise, Dialysis with pre-dialytic physical exercise, Dialysis with per-dialytic physical exercise
- Where
- 2 sites in France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Montpellier
Cervical Cancer
Improving Diagnostics in Cervical Dysplasia
Cervical cancer is the fourth most common cancer in women worldwide. It is caused by an infection with human papillomavirus (HPV).
- Trial name
- IDEAL (NCT05283421)
- Testing
- Estrogen
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Coronary Artery Disease, Postoperative Pain
Five Multimodal AI Configurations Versus Expert Anaesthesiologists for Classifying Pecto-Intercostal Fascial Plane Block Spread in CABG
This prospective observational cohort with a nested archived-image reader study compared the sonographic pecto-intercostal fascial plane block classifications of five general-purpose multimodal artificial-intelligence…
- Trial name
- NCT07581678
- Testing
- Pecto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Nerve Block, Nerve Blocks
Blast-related Regional Anaesthesia and Peripheral nerVe Injury Evaluation
This randomized study will examine whether ultrasound-guided regional anaesthesia (a nerve block) contributes to new or worsening peripheral nerve problems after blast-related limb trauma.
- Conditions
- Nerve Block, Nerve Blocks, Nerve Injury, Blast Injury
- Trial name
- BRAVE (NCT07879508)
- Testing
- Standardized Multimodal Analgesia, Ultrasound-Guided Regional Anaesthesia
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Injury Arm
Comparison of the Onset Times and Durations of Actions of Different Local Anesthetic Mixture Solutions [CODLAM]
Objective To investigate the onset times and duration of local anesthetic mixture solutions used for axillary-supraclavicular brachial plexus blocks and to compare the quality of anesthesia in patients with trauma of the upper…
- Trial name
- CODLAM (NCT03454789)
- Testing
- brachial plexus block for LB Group, brachial plexus block for BS Group, brachial plexus block for LS Group
- Volunteers
- 85 people
- Sponsor
- University of Pecs
Thoracic Diseases
Lungs Aeration Changes Examined by Impedance Tomography During High Frequency Jet Ventilation.
The purpose of this study is attempt to establish optimum drive pressure of high frequency jet ventilation during rigid bronchoscopy to ensure good aeration of the lungs examined by electrical impedance tomography.
- Trial name
- DPEIT (NCT02997072)
- Volunteers
- 30 people
- Sponsor
- Silesian University of Medicine
Breast Cancer, Breast Neoplasm
CRYoablation for Small Tumors As Local Treatment - SIX Trial
To demonstrate the non-inferiority of cryoablation compared to breast surgery for the local treatment of early-stage breast cancer and to conduct a cost-minimization analysis comparing direct costs between treatments.
- Trial name
- CRYSTAL - SIX (NCT06839001)
- Testing
- cryoablation, Breast Surgery (Lumpectomy or Mastectomy)
- Where
- 2 sites in Brazil
- Volunteers
- 750 people
- Sponsor
- Hospital do Coracao
Abortion
Evaluation of of a Prefixed 50% N2O- 50%O2 Mixture in Legal Abortion Under Local Analgesia
To evaluate effectiveness of a prefixed 50% N2O- 50%O2 mixture in legal abortion under paracervical block.
- Trial name
- NCT00769912
- Testing
- 50% N2O- 50%O2 mixture
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Fractures, Open, Surgical Wound Infection
Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures
The purpose of this study is to determine if local administration of vancomycin powder at the site of Grade I-IIIA open fractures at the time of surgery will be an efficacious method to lower infection rates in open fracture…
- Trial name
- NCT02400112
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Tennessee
Advanced Urothelial Carcinoma
9MW2821 Combined With Toripalimab Injection in Subjects With Local Advanced or Metastatic Urothelial Cancer
This is a phase Ib/II, open-label, multicenter clinical study to evaluate the safety, tolerability, efficacy, pharmacokinetics and immunogenicity of 9MW2821 combined with Toripalimab injection in subjects with local advanced or…
- Trial name
- NCT06079112
- Testing
- 9MW2821, Toripalimab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Acute Kidney Injury
Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy
Critically ill patients with acute kidney injury (AKI) are at high risk of bleeding on account of coagulopathy, platelet dysfunction, frequent liver dysfunction and invasive procedures.In patients at high risk of bleeding…
- Trial name
- NCT01269112
- Testing
- citrate regional anticoagulation
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University Hospital, Geneva
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.