Clinical trials: Local Disease
Atrial Fibrillation, Left Atrial Appendage Occlusion
RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients
Percutaneous left atrial appendage closure (LAAC) is an effective strategy for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Occlusion, General Anesthesia, Local Anesthesia
- Trial name
- NCT06969118
- Testing
- Minimalism Transcatheter LAAC Group, Standard Transcatheter LAAC Group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Zhongshan Hospital
Postoperative Pain
Bupivicaine to Reduce Postoperative Pain in Laparoscopic Ventral Hernia Repair
The investigators are testing to see if infusion of bupivicaine between the mesh and abdominal wall can reduce postoperative pain and decrease use of narcotics in the postoperative setting.
- Trial name
- NCT01530815
- Testing
- Bupivicaine Infusion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Chang, Steve S., M.D.
Analgesia, Topical Anesthetic
Ametop Compared to Ametop With Pain Ease Spray
The investigators propose to examine if Pain Ease spray, used as an adjunct to the topical anesthetic Ametop Gel, can improve the percentage of pain-free IV starts.
- Trial name
- NCT03749915
- Testing
- Pain Ease Cold Spray, Ametop
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of British Columbia
Cerebral Ischemia-Hypoxia
Effect of Sedatives on Regional Cerebral Oxygen Saturation
Compare the changes of regional cerebral oxygen saturation during midazolam or dexmedetomidine sedation for spinal anesthesia in the elderly patients who undergoing femur surgery.
- Trial name
- 2 (NCT02966743)
- Testing
- Midazolam, Dexmedetomidine
- Where
- South Korea
- Sponsor
- Gachon University Gil Medical Center
Pain, Postoperative
Local Infiltration Analgesia in Bilateral Knee Arthroplasty - Efficacy of Subcutaneous Wound Infiltration With Local Anesthetic
Local infiltration analgesia is effective in total knee arthroplasty for postoperative pain management, but the efficacy of subcutaneous wound infiltration has not been evaluated.
- Trial name
- NCT00927225
- Testing
- ropivacaine 0.2%, 50 mL, normal saline
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Cervical Squamous Cell Carcinoma
Nimotuzumab Combined With Chemoradiotherapy Versus Chemoradiotherapy for Local Advanced Cervical Squamous Cell Carcinoma
To investigate the efficacy and safety of nimotuzumab combined with concurrent chemoradiotherapy versus concurrent chemoradiotherapy in the treatment of local advanced cervical squamous cell carcinoma.
- Trial name
- NCT04678791
- Testing
- Nimotuzumab, Cisplatin, External-beam radiation
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Peking University Third Hospital
Cerebral Oxygen Saturation, Postoperative Delirium
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive…
- Conditions
- Cerebral Oxygen Saturation, Postoperative Delirium, Carotid Endarterectomy
- Trial name
- NCT05198635
- Testing
- local cerebral oxygen saturation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Invitro Fertilization
Endometrial Injury and Implantation Rates Before First ICSI Cycle
Midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix, the step that will be beneficial…
- Trial name
- NCT02660125
- Testing
- Endometrial scratch injury
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Hypertension
Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients
Pain control in dentistry is an important factor for reducing the fear and anxiety associated with dental procedures. For tooth extraction, it is mandatory to use resources to manage pain and discomfort such as adequate…
- Trial name
- NCT06927726
- Testing
- 4% Articaine HCL With 1:100,000 Epinephrine, 3% plain mepivacaine HCL
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Head and Neck Cancer, Oropharyngeal Carcinoma
Thermotherapy for Head and Neck Cancer Patients
This phase I, single-center study evaluates the safety, tolerability, and recommended phase II dose (RP2D) of mild hyperthermia (thermotherapy) when added to standard-of-care treatment in patients with locally advanced head and…
- Conditions
- Head and Neck Cancer, Oropharyngeal Carcinoma, Hypopharyngeal Carcinoma, Laryngeal Carcinoma
- Trial name
- TANCAP-I (NCT07690618)
- Testing
- Thermotherapy, Radiotherapy, Concurrent chemoradiation
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative
Ultrasound-guided Dual TAP Block: Magnetic Resonance (MR) Evaluation of the Distribution of Local Anesthetic
Using Magnetic resonance (MR) scanning and ultrasonography the investigators wish to investigate, in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young…
- Trial name
- NCT01305603
- Testing
- Bupivacaine, Injection
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Breast Cancer
PET Imaging to Determine the Role of PET in the Assessment of Regional Disease in Breast Cancer (PET PREDICT Trial)
The overall goal of this study is to determine how FDG-PET can be incorporated into the assessment of the axilla in the staging and treatment of women with early stage breast cancer.
- Trial name
- NCT00201942
- Testing
- PET scan
- Where
- 10 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Hepatecellular Carcinoma
Efficacy and Safety of Camrelizumab Plus Rivoceranib and Local Therapy for Hepatocellular Carcinoma With Lung Metastases (CAPLocal) : A Multicentre, Single-Arm,Prospective Cohort Study
1.1. Main Objectives The objective response rate (ORR) determined by the researchers based on RECIST v1.1 was used to evaluate the efficacy of systemic therapy (carrycept combined with apatinib) in combination with or without…
- Trial name
- NCT07482670
- Volunteers
- 32 people
- Sponsor
- Xiangya Hospital of Central South University
Neck Pain
The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time
This study will use microdialysis to investigate myofascial pain. This pain is characterized by "trigger points" (exquisitely tender spots) in a group of tense muscle fibers that extend from the trigger point to the muscle…
- Trial name
- NCT00042276
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Brain Metastases, Adult
Stereotactic Radiotherapy Management of Brain Metastases: the Value of a Longitudinal Multimodal Approach (POSTPONE)
The management of brain metastases has evolved́ rapidly in recent years. It is estimated that 20% to 40% of cancer patients will develop brain metastases (BM) during the course of their disease.
- Trial name
- POSTPONE (NCT06029140)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
Oligometastatic Cancer
Clinical Utility of ctDNA in the Treatment of Oligometastatic Disease
This prospective observational study investigates the clinical utility of circulating tumor DNA (ctDNA) in patients with oligometastatic disease (OMD) undergoing definitive-intent local ablative treatment (LAT).
- Trial name
- NCT07426250
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital
Fontan Procedure, Hypoplastic Left Heart Syndrome
Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques
The investigators are beginning a clinical research study here at UCSF to learn more about how hearts with single ventricles work.
- Conditions
- Fontan Procedure, Hypoplastic Left Heart Syndrome, Tricuspid Atresia, Double Inlet Left Ventricle
- Trial name
- NCT01107990
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postoperative Pain
The Effect of Local Anaesthetic Volume on Nerve Block Duration and Nerve Block Duration Variability
The aim is to investigate the effect of perineural administration of a series of different volumes of local anaesthesia (ropivacaine 0.2%) on nerve block duration and the variability of the duration in the common peroneal nerve…
- Trial name
- NCT02829697
- Testing
- Ropivacaine
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Other Disorders of the Eye Following Cataract Surgery
The Measurements of End-tidal Carbondioxide Levels
Purpose: The aim of this retrospective study is to investigate the end tidal carbon dioxide pressure (ETCO2) values in order to determine the carbon dioxide accumulation under drape and to investigate it's hemodynamic effects…
- Trial name
- NCT03923283
- Volunteers
- 42 people
- Sponsor
- Duzce University
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