Clinical trials: Local Disease
Keloid Scar
Keloid Scarring: Treatment and Pathophysiology
To clarify the mechanisms of Keloid scar formation. Elucidate the action and therapeutic value of 5-FU in Keloid scar treatment Identify the genetic link with Keloid scar formation.
- Trial name
- NCT01295099
- Testing
- 5- fluorouracil, radiotherapy, Triamcinolone
- Where
- United Kingdom
- Sponsor
- Queen Mary University of London
Hernia, Inguinal, Chronic Postoperative Pain
Surgical Outcomes Following Neurectomy Based Upon Response to Local Anesthetic Injection in Chronic Groin Pain
The management of chronic pain after inguinal hernia surgery presents unique challenges. Ilioinguinal nerve blocks are often used in the initial treatment of this disease.
- Trial name
- NCT05386693
- Testing
- Ilioinguinal nerve block
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Local Anesthetic, Ultrasound
TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures
The aim of this work to compare between the efficacy of ultrasound guided TAP block with dexamethasone as an adjuvant versus ultrasound guided TAPB with methyl prednisolone as an adjuvant to local anesthetic for postoperative…
- Conditions
- Local Anesthetic, Ultrasound, Pain, Acute
- Trial name
- NCT06131593
- Testing
- TAPB with dexamethasone as an adjuvant to local anesthetics, TAPB with methylprednisolone as an adjuvant to local anesthetics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Caesarean Scar Pregnancy
Surgical Evacuation Versus Methotrexate Injection in Treatment of Caesarean Scar Pregnancy [Clinical Trial ]
The aim of the study is to compare the effectiveness and the complications of Ultrasound guided surgical evacuation versus using combined local and systemic methotrexate injection for management of caesarean scar pregnancy.
- Trial name
- NCT07288307
- Testing
- Surgical evacuation and methotrexate injection
- Volunteers
- 42 people
- Sponsor
- Minia University
Breast Cancer, Metastases
SABR PRIMER - Evaluating Stereotactic Ablative Radiotherapy for Primary and Regional Breast Tumors
The study is being done to determine if stereotactic ablative radiotherapy (SABR) can control tumour growth for patients with metastatic breast cancer.
- Trial name
- SABR PRIMER (NCT06937281)
- Testing
- SABR
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- British Columbia Cancer Agency
Healthy
A Phase 1 Study To Evaluate Tolerability, Safety, And Pharmacokinetics Of Topical PF-06263276 In Healthy Subjects
PF-06263276 is a first in class inhibitor of the Janus kinase (JAK) enzymes 1, 2, 3 and tyrosine kinase 2 (TYK2) that is being developed for the treatment of chronic plaque psoriasis.
- Trial name
- NCT01981681
- Testing
- PF-06263726
- Where
- Belgium
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Pfizer
Elderly, Alzheimer Disease
Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum
The goal of this clinical trial is to explore and verify the preventive effects of melatonin on the progression of Alzheimer's disease.
- Conditions
- Elderly, Alzheimer Disease, Melatonin, Cognitive Decline
- Trial name
- NCT06756828
- Testing
- Melatonin, Cognitive behavioral therapy group for insomnia
- Volunteers
- 40 people
- Sponsor
- Saint Vincent's Hospital, Korea
Stomach Neoplasms, Metastatic or Locally Advanced Gastric Cancer
huC242-DM4 Treating Patients With Metastatic Gastric or Gastroesophageal Junction Carcinomas
To assess the response rate of huC242-DM4 given as an intravenous infusion to patients with metastatic or locally advanced gastric or gastroesophageal junction cancer.
- Conditions
- Stomach Neoplasms, Metastatic or Locally Advanced Gastric Cancer, Metastatic or Local Advanced GE Junction Cancer
- Trial name
- NCT00620607
- Testing
- huC242-DM4
- Where
- 4 sites in United States
- Sponsor
- ImmunoGen, Inc.
Rib Fracture Multiple, Anesthesia, Local
Surgical Stabilization of Rib Fractures While Awake or Under Appropriate Sedation by Paravertebral Block
Tracheal intubation and general anesthesia has been considered a safe and conventional routine methodology for thoracic surgery, include multiple rib fratcure.
- Trial name
- NCT04536311
- Testing
- internal fixation of mulitiple rib fracture
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Peridontitis
This Study Evaluates the Clinical Effect of Adding Spermidine Gel to Minimally Invasive Non-surgical Periodontal Therapy (MINST) to Improve Periodontal Health.
This study investigates the effectiveness of using a spermidine-based gel as an adjunct to minimally invasive non-surgical periodontal therapy (MINST) for treating periodontitis.
- Trial name
- NCT06792916
- Testing
- spermidine and minimally invasive non surgical tecnique, peridontal therapy (minimally invasive non surgical tecnique)
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Luca Ramaglia
Actinic Keratoses
Phase I/IIa Trial to Evaluate AVX001 Gel in Doses of 1% or 3% Compared With Vehicle Over Four Weeks of Field-directed Treatment Period in Adult Subjects With AK
Actinic keratosis (AK), also known as solar keratosis, is a common skin condition characterised by abnormal growth of skin cells caused by long-term sun exposure.
- Trial name
- COAKS (NCT05164393)
- Testing
- AVX001
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Coegin Pharma AB
Post-Operative Pain
LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery
After surgery on his penis, your child will probably have some pain. The investigators will give you a prescription for acetaminophen (Tylenol) with codeine, given by mouth (orally), for pain.
- Trial name
- LMX-4 (NCT00847093)
- Testing
- LMX4
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ferndale Laboratories, Inc.
Benign Prostatic Hyperplasia
UroLift System TOlerability and ReCovery When Administering Local Anesthesia
The purpose of the study is to evaluate procedure tolerability and surgical recovery following the UroLift® system procedure when conducted with local anesthesia in subjects with symptomatic benign hyperplasia (BPH).
- Trial name
- LOCAL (NCT01876706)
- Testing
- UroLift® System
- Where
- 7 sites in United States
- Volunteers
- 51 people
- Sponsor
- NeoTract, Inc.
Carpal Tunnel Syndrome, Anesthesia
Surgical Treatment of Carpal Tunnel Syndrome: Local Anesthesia With Epinephrine x Intravenous Regional Anesthesia.
The anesthetic technique of choice for surgical treatment of CTS varies among surgeons. In the last decade some studies have described the performance of this surgery using local anesthesia with adrenaline without the necessity…
- Trial name
- NCT02986347
- Testing
- Intravenous regional anesthesia (Bier), Local anesthesia with adrenaline
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Alvorada
Breast Cancer
Patient Registry: Partial Breast Irradiation
This is an Aurora Health Care system registry of patients receiving accelerated partial breast irradiation and external beam.
- Trial name
- PBI Registry (NCT01127971)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Wake Forest University Health Sciences
Regional Anesthesia Morbidity, Pain, Postoperative
Randomized Trial of Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride on Quality of Recovery for Video-assisted Thoracic Surgery
Video-assisted thoracoscopic surgery (VATS) has emerged as the standard surgical modality for pulmonary tumor. Compared with open thoracotomy, VATS is associated with reduced surgical trauma, attenuated postoperative pain, and a…
- Trial name
- LB-ESPB (NCT07141667)
- Testing
- Erector spinae plane block with liposomal bupivacaine, Erector spinae plane block with bupivacaine HCL
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Diabetes Mellitus, Type 2
Regional Fatty Acid Metabolism in Humans
There are several studies looking at how dietary fat is metabolized by humans. We give special meals and collect blood, breath, urine and fat samples to study how people burn and store dietary fat.
- Trial name
- NCT00068887
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Development of Early Diagnostic Techniques and Setup of Local Therapeutic Guidelines and Standards
End-stage renal disease (ESRD) is a healthy, social and economic threat worldwide. In the past ten years, the incidence and prevalence of ESRD patients have tremendously increased, ranking at the top in the world.
- Trial name
- Hmodialysis (NCT00912704)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Persistent Idiopathic Facial Pain (PIFP)
Deciphering Persistent Orofacial Pain - PIFP
Persistent non-dental orofacial pain is common yet poorly characterised, and its pathophysiology remains largely unknown. Two clinically similar entities are distinguished: post-traumatic trigeminal neuropathic pain (PTNP), in…
- Trial name
- NCT07791004
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Oligometastatic Disease, Prostatic Cancer, Castration-Resistant
Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer
The purpose of this randomized trial is to investigate the efficacy and toxicity of percutaneous high-dose radiotherapy in patients with oligometastases of hormone refractory prostate cancer.
- Trial name
- OLI-CR-P (NCT04141709)
- Testing
- local ablative radiotherapy
- Where
- 4 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Technische Universität Dresden
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