Clinical trials: Local Disease
Bone Metastases
Regional Database for Collecting Clinical-biological and Imaging Data "Secondary Bone Oncology and Bone Localizations of Hematologic Diseases"
Improving the effectiveness of cancer treatments makes it possible to lengthen patient survival. It is therefore important to ensure that the quality of life is also maintained by reducing pain and handicap.
- Trial name
- OOSLOH (NCT05495802)
- Sponsor
- University Hospital, Lille
Neoplasm of Lung, Thoracic Surgery, Video-Assisted
Efficacy of Continous Regional Anesthesia Using m. Erector Spinae Catheter After VATS Procedures
Investigators will analyze the efficacy of continuous regional anesthesia through a catheter under erector spinae muscle in a prospective, randomized, double blind, placebo-controlled study.
- Trial name
- NCT04062045
- Testing
- Ropivacaine Hcl 0.2% Inj Vil 10Ml, Saline 0.9%
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- Surgery Bitenc
Sacroiliac Joint Dysfunction
Local Muscle Vibration Versus Muscle Energy Technique In Sacroiliac Joint Dysfunction
The purpose of this study is to compare the effect of Local Muscle Vibration versus Muscle energy technique on pain intensity, pain pressure threshold, functional disability, and innominate angle tilt in SIJD.
- Trial name
- SIJD (NCT06227637)
- Testing
- Local Muscle Vibration compared to Muscle energy technique in SIJD
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Complex Regional Pain Syndrome
The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome
The aim of this trial is to determine the potential effects and mechanisms of cannabinoid-induced pain relief in complex regional pain syndrome (CRPS).
- Trial name
- NCT06393101
- Testing
- BRC-002
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Diego
Pulmonary Disease, Chronic Obstructive
Acute Effects of a Stretching Program of the Rib Cage Muscles on Patients With COPD During Exercise
Investigate the effects of stretching the muscles of the rib cage in individuals with COPD during exercise.
- Trial name
- NCT02383277
- Testing
- Stretching, Control, Exercise
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Blood Loss
Local Tranexamic Acid During Vaginal Hysteractomy to Reduce Blood Loss
Assessing the efficiency of Prophylactic use of local tranexamic acid during vaginal hysterectomy to reduce blood loss during operation
- Trial name
- NCT04760301
- Testing
- local tranexamic acid injection, local normal saline injection to cervix
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Supraclavicular Brachial Plexus Block
Th Effects of a Drug Dexmedotemidine in Regional Anesthesia in Participants Undergoing Upper Limb Surgeries
In this study, we will assess the effect of combined Dexmedetomidine and Bupivacaine analgesia on the onset and duration of anesthesia in supraclavicular plexus block compared to Bupivacaine alone.
- Trial name
- NCT04981951
- Testing
- Dexmedetomidine
- Where
- Palestinian Territories
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zaher Nazzal
Severe Acute Malnutrition in Childhood
Development and Field Testing of Ready-to-use-therapeutic Foods Made of Local Ingredients in Bangladesh for SAM Children
Around 0.5 million under-five children are currently suffering from severe acute malnutrition (SAM) in Bangladesh and are at risk of death. Children with SAM and complications should be treated in a health care facility.
- Trial name
- NCT01889329
- Testing
- RUTF-1, RUTF-2, Plumpynut
- Where
- Bangladesh
- Volunteers
- 490 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pain, Postoperative, Quality of Life
Efficacy of Two Local Anesthetics on Quality of Life After Endodontic Treatment
In this randomized controlled double-blinded study, subjects will be assigned to one of two study groups to either be anesthetized with Bupivacaine or Lidocaine prior to needed treatment of pulpectomy/endodontic debridement on a…
- Trial name
- B-OHIP14 (NCT04787731)
- Testing
- Bupivacaine Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Breast Cancer
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
The purpose of this randomized Phase III study is to determine whether preoperative focused microwave heat treatment and chemotherapy combined are more effective than preoperative chemotherapy alone in the treatment of large…
- Trial name
- Medifocus301 (NCT01204801)
- Testing
- Focused Microwave Thermotherapy, Chemotherapy (control)
- Where
- 2 sites in United States, Canada
- Volunteers
- 238 people
- Sponsor
- Medifocus, Inc.
Anxiety
Assessment of the Aromatherapy to Alleviate Peri Operative Anxiety in Ambulatory Elective Upper Limb Surgery Under Loco-regional Anesthesia
AROMA study is a randomised controlled parallel-group single-site study. Patients randomized in the experimental group benefit from the aromatherapy at their arrival in the operating theatre in the recovery room.
- Trial name
- AROMA (NCT03583801)
- Testing
- Olfactory aromatherapy, without aromatherapy
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Lille
Prostate Cancer
177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer
The purpose of this study is to test the effectiveness of the experimental drug, 177Lu-J591 in combination with ketoconazole and hydrocortisone against prostate cancer.
- Trial name
- NCT00859781
- Testing
- 177Lu-J591, Ketoconazole, Hydrocortisone
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- Weill Medical College of Cornell University
Long Term Care
Identifying Key Attributes and Learning From a Local Falls Prevention Ambassador Programme
Managing falls for care home residents can be challenging for care home staff who work in complex settings and with residents with complex needs.
- Trial name
- NCT06946303
- Testing
- Survey, Interview, Observation
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Nottingham
Acute Pancreatitis, Pancreatic Fluid Collection
Management and Outcomes of Local Complications of Acute Pancreatitis and Postoperative Pancreatic Fistula
This multicenter prospective observational registry will evaluate the clinical characteristics and treatment outcomes of adults with local complications of acute pancreatitis or postoperative pancreatic fistula.
- Conditions
- Acute Pancreatitis, Pancreatic Fluid Collection, Postoperative Pancreatic Fistula
- Trial name
- WONDERFUL (NCT07862088)
- Testing
- Routine Clinical Management of Local Complications
- Where
- 12 sites in Japan
- Volunteers
- 5,000 people
- Sponsor
- Tokyo University
Postoperative Hemorrhage, Postoperative Anemia
Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients
The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to…
- Conditions
- Postoperative Hemorrhage, Postoperative Anemia, Postoperative Blood Loss
- Trial name
- NCT05889494
- Testing
- Autologous Whole Blood Management, Standard Care involving allogenic and/or derivative transfusion.
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Dental Anxiety, Pain
Effect of Therapeutic Play and Virtual Reality Glasses on Pain and Anxiety in Children
Background: A child's first dental experience plays a crucial role in treatment success and in fostering cooperation during future visits.
- Trial name
- NCT07375056
- Testing
- Intervention 1: Therapeutic Play Group, Intervention 2: Virtual Reality Glasses Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Breast Cancer
Safety of Breast-Conserving Surgery for Multifocal or Multicentric Breast Cancer
The objective of this observational study is to evaluate the oncological safety of breast-conserving surgery combined with standard postoperative radiotherapy in adult female patients diagnosed with multifocal or multicentric…
- Trial name
- NCT07677956
- Testing
- Breast-conserving surgery, postoperative radiotherapy and individualized adjuvant systemic therapy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Transrectal Systematic Prostate Biopsy Related Pain
A Study on the Pain Control Effect of the Anesthetic Method During Prostate Biopsy: Comparison Between Pelvic Plexus Block and Periprosthetic Nerve Block
This study assesses differences in the effects of pelvic plexus block and periprostatic nerve block among various anesthetic methods that reduce the pain caused by prostate biopsy.
- Trial name
- NCT03681522
- Testing
- Pelvic plexus block, Periprostatic nerve block
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Breast Cancer
Temperature-Sensitive Liposomal Doxorubicin and Hyperthermia in Treating Women With Locally Recurrent Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as liposomal doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00346229
- Testing
- filgrastim, pegfilgrastim, lyso-thermosensitive liposomal doxorubicin(Thermodox)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
HİP FRACTURE, Hip Surgery (Lateral Incision)
Perioperative Analgesic Effects of PENG Versus PENG Plus LFCN Block in Hip Surgeries
This study is designed to find the best way to control pain after hip surgery performed through a side (lateral) incision. Two different types of nerve blocks used before the operation will be compared.
- Conditions
- HİP FRACTURE, Hip Surgery (Lateral Incision), Postoperative Pain Management, Analgesia, Postoperative
- Trial name
- NCT07329829
- Testing
- Pericapsular nerve group (PENG) block, Lateral Femoral Cutaneous Nerve (LFCN) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
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