Clinical trials: Local Disease
Carpal Tunnel Syndrome
Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?
This study is being conducted to determine whether addition of a longer-acting local anesthetic to our current anesthetic protocol improves the post-operative pain after carpal tunnel release.
- Trial name
- NCT04833777
- Testing
- Local Anesthetics Lidocaine, Local Anesthetics Bupivacaine
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Breast Cancer
Using the Conture® Multi-Lumen Balloon to Deliver Accelerated Partial Breast Brachytherapy
This multiple site, prospective, non-randomized study has been designed to compile information on the efficacy of the Contura™ MLB in delivering APBI in appropriately selected patients through evaluation of dosimetric success as…
- Trial name
- NCT00699101
- Testing
- Conture Multi-Lumen Balloon
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- SenoRx, Inc.
Surgery, Anesthesia, Local
Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures
The purpose of this study is to determine whether eating solid food prior to undergoing a wide awake local-only no tourniquet (WALANT) procedure reduces anxiety in patients or has any effect on outcomes.
- Conditions
- Surgery, Anesthesia, Local, Fasting
- Trial name
- NCT05819801
- Testing
- Non-fasting, Fasting
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of California, Irvine
Carcinoma, Basal Cell
Basal Cell Carcinomas Treated With Ablative Fractional Laser and Ingenol Mebutate
A prospective clinical, uncontrolled, open-label, explorative phase 2a trial on patients with histologically-confirmed superficial and nodular basal cell carcinoma (BCC).
- Trial name
- NCT03569345
- Testing
- AFXl-assisted ingenol mebutate delivery
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Merete Haedersdal
Peripheral Arterial Disease, Intermittent Claudication
The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication
The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related intermittent claudication.
- Trial name
- NCT01799057
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Baker Heart and Diabetes Institute
Giant Cell Tumor of Bone
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location.
- Trial name
- NCT03295981
- Testing
- Zoledronic Acid
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Sciatic Nerve Blockade for Foot/Ankle Surgery
Circumferential Spread of Anesthetic and Success in Sciatic Nerve Blockade
Current practices when performing any peripheral nerve block may or may not involve ensuring circumferential spread of local anesthetic around the nerve.
- Trial name
- NCT00802581
- Testing
- Circumferential spread of local anesthetic, Non-circumferential spread of local anesthetic
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University Health Network, Toronto
Rheumatoid Arthritis
A Phase IV Study to Evaluate the Effect of Subcutaneous (SC) Tocilizumab Administered to Participants With Rheumatoid Arthritis (RA) Assessed Using Disease Activity Score (DAS28)
The purpose of this clinical trial is to prospectively evaluate RA activity using the assessment of change in DAS28 under local conditions in Slovakia in participants who are treated with subcutaneously administered tocilizumab…
- Trial name
- NCT02534311
- Testing
- Tocilizumab
- Where
- 5 sites in Slovakia
- Volunteers
- 60 people
- Sponsor
- Hoffmann-La Roche
Pain, Postoperative
Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia
In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous…
- Trial name
- CATCH (NCT01077752)
- Testing
- continuous ropivacaine preperitoneal infusion, intravenous lidocaine infusion, parenteral analgesia combining acetaminophen and morphine
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arbovirus Infections, SARS-CoV Infection
Human Epidemiology of Newly Identified Arboviruses
A local network is being set up to study the impact of arboviruses in our region. It is committed to a one-health approach, in particular with research without a priori for new viruses hosted among vectors and wildlife.
- Trial name
- ARBODOCC (NCT04954352)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Healthy Volonteers
Less is Better? Effectiveness of a Short Local Vibration Protocol on Neuromuscular Function
Local vibration is a non-invasive neuromuscular stimulation modality used in training and rehabilitation for its effects on neuromuscular function, particularly its ability to induce nervous adaptations.
- Trial name
- VIB-EXPRESS (NCT07344298)
- Testing
- Local vibration protocol
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Stroke
Direct-to-angio Approach From loCal hOspitals Based on a PoInt-of-care bLOod Test for LVO
Direct-to-angio approach from loCal hOspitals based on a PoInt-of-care bLOod Test for LVO (COPILOT) is a multi-center, prospective, cluster-randomized crossover trial that will evaluate if the triage assessment to thrombectomy…
- Trial name
- COPILOT (NCT06910163)
- Testing
- Diagnostic standard of care, LVOne Test
- Where
- Puerto Rico
- Volunteers
- 520 people
- Sponsor
- Juan Vicenty
Hypoxia, Oxygen Therapy
Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia
High-flow nasal cannula (HFNC) that uses heated and humidified oxygen was recently introduced for bedside care. It has been shown to be associated with reduced risks of tracheal intubation rates and mortality in adult hypoxic…
- Conditions
- Hypoxia, Oxygen Therapy, High Flow Nasal Cannula, Ventilation
- Trial name
- NCT02943863
- Testing
- HFNC followed by conventional nasal cannula, Conventional nasal cannula followed by HFNC
- Volunteers
- 24 people
- Sponsor
- Asan Medical Center
Periodontal Pocket
Local Delivery of Silk Fibroin and Chlorhexidine
The current study is a prospective randomised split mouth study to evaluate the effect of Silk fibroin as drug delivery system while simultaneously assessing the efficacy of silk fibroin in comparison to chlorhexidine.
- Trial name
- NCT06050863
- Testing
- silk fibroin, Chlorhexidin, combination of silk fibroin and chlorhexidine
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Pain, Postoperative
Effectiveness of Adductor Canal Block Using Liposomal Bupivacaine
With aging of population, osteoarthritis of knees and hips become major orthopaedic problems in Hong Kong. Osteoarthritis of knees and hips are associated with significant pain problem and functional disability.
- Trial name
- NCT04003506
- Testing
- Liposomal bupivacaine, Bupivacaine Injection
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Benign Gynecologic Neoplasm
Postoperative Analgesic Efficacy of Continuous Wound Infusion After Laparoscopy
Studies evaluating the effectiveness of continuous wound infusion (CWI) to manage postoperative pain following laparoscopy are markedly lacking.
- Trial name
- PAIN (NCT03645304)
- Testing
- Ropivacaine, 0.9% saline group, ON-Q Painbuster Silver Soaker
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Kangbuk Samsung Hospital
AKI - Acute Kidney Injury, CKD 5D, Hemodialysis
Personalized Two-stage Regional Citrate Anticoagulation for CRRT in Patients With Citrate Metabolism Impairment
The purpose of this study is to compare the efficacy and safety of an individualized two-stage calcium supplementation method versus a conventional commercial RCA-CRRT module in RCA-CRRT for patients with citrate metabolism…
- Conditions
- AKI - Acute Kidney Injury, CKD 5D, Hemodialysis, Hepatic Failure
- Trial name
- PRECISE (NCT07579663)
- Testing
- Two-stage calcium supplementation in RCA-CRRT, Commercial RCA-CRRT module
- Volunteers
- 142 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Diabetes Mellitus, Chronic Periodontitis
Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus
A study on the effect of locally delivered aloe vera gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis patients with controlled type II diabetes mellitus.The evaluation of Plaque Index…
- Trial name
- NCT02437747
- Testing
- SRP + Aloe, SRP
- Volunteers
- 15 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Low Back Pain
Translation of Quebec Back Pain Disability Scale Into Local Languages of Pakistan.
The aim of the present study is to translate the Quebec Back Pain Disability Scale into Pashto, Punjabi, Sindhi and Balochi languages.
- Trial name
- NCT04831749
- Where
- Pakistan
- Volunteers
- 800 people
- Sponsor
- Riphah International University
Corneal Defect
The Germinal Peptide Eye Drops in Healthy Volunteers in a Clinical Study
The subjects of this study were healthy subjects, who were given medicine in a single dose group: 0.004%.
- Trial name
- NCT03967548
- Testing
- Germinal peptide eye drops
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
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