Clinical trials: Local Disease
Lung Neoplasms, Emphysema
Computed Tomography Assessment of Regional Ventilation (CURVE)
This study uses CT scans to assess airflow in the lung, the scan is quick, cheap and painless. The information from the scan may help doctors tell which patients are suitable to have surgery to cure early stage lung cancer.
- Conditions
- Lung Neoplasms, Emphysema, Lung Diseases, Interstitial, Pulmonary Disease, Chronic Obstructive
- Trial name
- CURVE (NCT02879773)
- Testing
- CTPVe
- Where
- United Kingdom
- Volunteers
- 131 people
- Sponsor
- Heart of England NHS Trust
Melanoma Stage III or IV
Dendritic Cell Vaccination in Melanoma Patients Scheduled for Regional Lymph Node Dissection
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients, and both immunological and clinical responses have…
- Trial name
- NCT00243594
- Testing
- Peptide-pulsed dendritic cells
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Hepato Cellular Carcinoma (HCC), Hand Foot Skin Syndrome
SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin
SHIELD is a single-center, open-label, single-arm prospective study designed to evaluate whether pre-emptive topical indomethacin can reduce sorafenib-associated hand-foot syndrome (HFS) in patients with advanced hepatocellular…
- Trial name
- NCT07560566
- Testing
- Topical Indomethacin
- Where
- Taiwan
- Volunteers
- 39 people
- Sponsor
- National Taiwan University Hospital
Hepatocellular Carcinoma
A Study of PTS100 in Primary HCC Patients
This study is being performed to evaluate the efficacy and safety of 30% PTS100 of total tumor volume as intra-tumoral injection therapy in primary Hepatocellular Carcinoma patients who are ineligible for operation or local…
- Trial name
- OASES (NCT03447951)
- Testing
- Para-Toluenesulfonamide
- Where
- 3 sites in Taiwan
- Volunteers
- 33 people
- Sponsor
- Gongwin Biopharm Co., Ltd.
Coronary Artery Disease
2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis
Development of myocardial ischemia, and/or myocarditis would induce different changes in myocardial contraction behavior pattern,which maybe very subtle, and may not be detected by the 2D and m-mode echocardiography examinations.
- Trial name
- TDI (NCT01092429)
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Peri-Implant Marginal Bone Loss, Dental Implantation
CBCT Assessment of Marginal Bone Changes With Ozone Therapy
This study examined whether adding local gaseous ozone to standard dental implant treatment could reduce early bone loss around implants. Fifty adults requiring matched implants on opposite sides of the same jaw participated.
- Trial name
- ozone-ımplant (NCT07687641)
- Testing
- Gaseous Ozone Application, Conventional Implant Placement
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Postoperative Pain
Comparison of the Efficacy of PENG Block in Combination With LFCN Block and Wound Infiltration
The ultrasound-guided approach for the blockade of articular branches of femoral and obturator nerves, pericapsular nerve group (PENG) block, is an effective method for postoperative analgesia in hip surgeries.
- Trial name
- NCT04681222
- Testing
- LFCN, Wound infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Derince Training and Research Hospital
Prostate Cancer
Radioligand fOr locAl raDiorecurrent proStaTe cancER
Approximately 50-60% of men undergoing salvage brachytherapy post cancer recurrence to the prostate have the disease controlled at 5 years.
- Trial name
- ROADSTER (NCT05230251)
- Testing
- 177Lu-PNT2002, High Dose Radiation
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Glenn Bauman
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
DVT, Osteoarthritis
Does Thinning the Blood During Surgery Prevent Blood Clots Following Total Knee Replacement Surgery
The goal of this study is to prevent blood clots from forming during surgery and a few days after total knee replacement surgery.
- Trial name
- NCT00253851
- Testing
- unfractionated heparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Parkinson's Disease
LFP Correlates of Movement Disorders
The purpose of this study is to record electrical brain activity during DBS surgery and after DBS surgery using the Medtronic Activa PC+S deep brain stimulation (DBS) system, a modified DBS pulse generator.
- Trial name
- NCT02115802
- Testing
- Activa PC+S
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Colorado Neurological Institute
Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to…
- Conditions
- Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee, Anesthesia, Local
- Trial name
- NCT07337772
- Testing
- LIA with different doses of Diprospan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Scoliosis
Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery
The goal of the surgical correction of scoliosis is to prevent progression of the curve or progression of restrictive lung disease. After scoliosis surgery, patients experience severe pain.
- Trial name
- NCT06451562
- Testing
- Lidocaine
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Assaf-Harofeh Medical Center
Amblyopia, Regional Blood Flow
Amblyopia and Neurovascular Coupling in the Retina of Humans
The visual disorder of amblyopia affects 2% to 3% of the population. Amblyopia is a developmental condition that is characterized by reduced vision of the eye due to the presence of a sensory impediment during visual development…
- Trial name
- NCT00312390
- Testing
- Flicker, Retinal Vessel Diameter, Retinal Blood Flow
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Crohn Disease
Treatment of Crohn's Complex Perianal Fistulas With Tissue Transplantation by Local Injection of Micro-fragmented Autologous Adipose Tissue.
multicentre randomized controlled prospective study aimed at evaluating the efficacy of the infiltration of microfractured adipose tissue in the healing of perianal fistulas not-responding to treatment with biologics, in order to…
- Trial name
- ATTIC (NCT05594862)
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Lipogems International spa
Nerve Block, Anesthesia, Local
Cutaneous Anesthesia of the Lateral Femoral Cutaneous Nerve
The purpose of this study is to investigate and describe the anatomical differences in distribution of the blocked area following a perineural LFCN (Lateral Femoris Cutaneous Nerve) block with either 8 ml or 16 ml of Ropivacaine…
- Conditions
- Nerve Block, Anesthesia, Local, Pain, Postoperative, Anatomical Distribution
- Trial name
- NCT03138668
- Testing
- Ropivacaine Injection
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Breast Cancer
Multimodality Treatment for Women With Stage II, Stage III, or Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver…
- Trial name
- NRR (NCT00006110)
- Testing
- trastuzumab, cyclophosphamide, doxorubicin hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Anesthesia, Local
Quadratus Lumborum Block (Transmuscular Approach) VS. TransversusAbdominus Plane Block(Unilateral Posterior Approach) for Perioperative Analgesia in Patients Undergoing Flank Incision Surgeries.
Severe perioperative pain experienced after surgical procedures performed by flank incision is mainly related to incision of many muscles.
- Trial name
- NCT03744923
- Testing
- transmuscular QL block, Transversus Abdominus Plane block
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Obstetric Pain, Anesthesia, Local
The Use of Electrical Stimulation for Determination of Epidural Catheter Placement
The aim of this study is to address the problem of epidural failure. The investigators theorize epidural failure can be due to inappropriate catheter movement and this may be related to the length of which the epidural catheter…
- Trial name
- NCT06055686
- Testing
- Electrical Epidural Stimulation Test
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Esophageal Neoplasms
Influence of Esophageal Washout on Local Carcinoma Recurrence After Curative Resection
The LOCARE-Trial is an investigator initiated, randomized-controlled trial with two parallel arms (n=60 each) and investigates the influence of esophageal washout on long-term outcomes in patients undergoing elective esophageal…
- Trial name
- LOCARE (NCT02676791)
- Testing
- Povidone-Iodine
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technische Universität Dresden
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