Clinical trials: Localised Prostate Cancer
Prostate Cancer
Proton-Based Stereotactic Ablative Body Radiotherapy for Prostate Cancer
Stereotactic ablative body radiotherapy (SABR), or stereotactic body radiotherapy (SBRT), is a specialized form of radiotherapy used to treat prostate cancer with five treatments over two weeks, compared with a conventional…
- Trial name
- NCT03159676
- Testing
- Proton beam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Prostate Cancer
An Efficacy and Safety Study With Licroca Depot, a Controlled Release Product, Injected Into the Prostate
The primary objective was to evaluate efficacy of a single dose of Liproca Depot in patients with localized prostate cancer. Primary efficacy variable was the proportion of patients showing PSA nadir.
- Trial name
- 2-HOF (NCT00913263)
- Testing
- 2-hydroxyflutamide (2-HOF) [Liproca Depot], 2-Hydroxyflutamide
- Where
- 2 sites in Finland
- Volunteers
- 24 people
- Sponsor
- Lidds AB
Prostate Carcinoma, Benign Prostatic Hyperplasia
Phase II Study to Evaluate the Safety and Efficacy of Prostatic Artery Embolization
This is a Phase II prospective clinical trial in which patients with prostate carcinoma and obstructive lower urinary tract symptoms electing for radiation therapy will undergo Prostatic Artery Embolization (PAE) prior to…
- Trial name
- NCT04879940
- Testing
- Merit Medical Embospheres, Radiation Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8
Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial
This clinical trial studies the side effects of image-guidance and online adaptation with stereotactic body radiation therapy (SBRT) for the treatment of patients with prostate adenocarcinoma that has not spread to other parts of…
- Conditions
- Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8
- Trial name
- NCT07276438
- Testing
- Biospecimen Collection, Computed Tomography, CT-guided Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate, Prostate Cancer
Focal Therapy in Localized Prostate Cancer: a Prospective Registry
The principal aim of the registry is to collect data on focal therapy (FT) for the treatment of intermediate-risk prostate cancer across Europe.
- Trial name
- JR (NCT06772116)
- Testing
- Focal Therapy
- Volunteers
- 1,000 people
- Sponsor
- Institut Mutualiste Montsouris
Localized Prostate Cancer
Treatment Decision Making in Early-Stage Prostate Cancer
We plan to test the effectiveness of a recently developed computer-based program that is designed to improve patient knowledge about prostate cancer treatments.
- Trial name
- NCT00196781
- Testing
- CD-ROM-based prostate cancer treatment education, CD-ROM-based prostate ca treatment education+decision tools
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Georgetown University
Prostate Cancer
Short-course Hypofractionated Radiotherapy for Localized Prostate Cancer
This study is aimed at providing further clinical evidence to support or refute the current understanding of biological sensitivity of prostate cancer to fractionated radiotherapy.
- Trial name
- NCT00126165
- Testing
- radiotherapy
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Alberta Health services
Prostate Cancer
Outcomes of Focal Ablation for Prostate Cancer
This study will be designed to define the efficacy and safety of ablative therapies in the management of localized prostate cancer and comprehensively evaluate quality of life outcomes and oncologic control following treatment.
- Trial name
- NCT05478694
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer
Preoperative Docetaxel for Localized Progressive Castration-resistant Prostate Cancer (CRPC)
Objectives: Primary: To evaluate the association of the probability of increase in phosphorylation of platelet-derived growth factor receptor (PDGFR) of > 0.5 in peripheral blood leucocytes following pre-operative docetaxel…
- Trial name
- NCT00811031
- Testing
- Taxotere, Prednisone
- Sponsor
- M.D. Anderson Cancer Center
Prostate Adenocarcinoma
A Phase I-II Dose Escalation Study of Stereotactic Body Radiation Therapy in Patients With Localized Prostate Cancer
The aim of this study is to test the safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in localized prostate carcinoma in patients for whom the standard treatment is the irradiation of the entire prostate gland…
- Trial name
- NCT02254746
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Prostate Cancer
Study of POMELLA™ Extract to Treat Prostate Cancer
This is a randomized, two-arm, placebo controlled trial to evaluate benefit of treatment using POMELLA™ extract on mechanisms known to drive prostate cancer.
- Trial name
- NCT01100866
- Testing
- POMELLA™ (pomegranate extract)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Vancouver Coastal Health
Prostatic Neoplasms
Adjuvant Apalutamide in Subjects With High-risk Localized or Locally Advanced Prostate Cancer After Radical Prostatectomy
The primary objective of this trial is to determine if adjuvant apalutamide in prostate cancer patients at high risk of developing subsequent metastatic disease results in prolonged biochemically recurrence-free survival after…
- Trial name
- ADAM (NCT04295447)
- Testing
- Standard of care, Apalutamide 60Mg Tab
- Where
- 21 sites in Austria, Germany
- Volunteers
- 190 people
- Sponsor
- Universität Münster
Cancer of the Prostate
European Randomised Study of TOOKAD® Soluble for Prostate Cancer vs Active Surveillance. Post Study Follow-up
This is an open observational extended follow-up study of patients originally randomized into TOOKAD® Soluble VTP therapy or active surveillance (control group). Additional 60-month follow-up study
- Trial name
- NCT04017325
- Testing
- no intervention (post study follow up)
- Where
- 36 sites in Finland, France and 6 more
- Volunteers
- 374 people
- Sponsor
- Steba Biotech S.A.
Prostate Cancer
Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate
This will be a Phase II study evaluating the effectiveness and toxicity of a specific radiation therapy regimen. This choice of daily dose is based on the prior published experience showing safety and efficacy of hypofractionated…
- Trial name
- NCT00809991
- Testing
- hypofractionation
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer, Prostate Adenocarcinoma
Two-Fraction Ultrahypofractionated Radiotherapy With Focal Boost for Intermediate Risk, Localized Prostate Cancer
The goal of this clinical trial is to assess the non-inferiority irradiating low and intermediate risk, localized prostate cancer in two fractions of radiotherapy, compared to five fractions of radiotherapy which is the standard…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Localized Prostate Carcinoma
- Trial name
- TURBO (NCT06518226)
- Testing
- Ultrahypofractionated MRgRT in 2 fractions, Standard of care: MRgRT in 5 fractions
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
PSA Level Greater Than Two, Stage IV Prostate Adenocarcinoma AJCC v7
Hormone Therapy and Intensity-Modulated Radiation Therapy in Treating Patients With Metastatic Prostate Cancer
This phase II trial studies how well hormone therapy and intensity-modulated radiation therapy work in treating patients with prostate cancer that has spread to other places in the body.
- Trial name
- NCT00544830
- Testing
- Bicalutamide, Goserelin Acetate, Intensity-Modulated Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- City of Hope Medical Center
Intermediate Risk Prostate Cancer (Diagnosis), Prostate Cancer
Dose-dEscalated MR-Guided Radiotherapy for Localized Prostate Cancer
DESTINATION 2 is a multi-centre randomised trial treating intermediate risk localised prostate cancer with 2 fraction Stereotactic Body Radiotherapy (SBRT).
- Trial name
- DESTINATION 2 (NCT07674225)
- Testing
- Prostate radical radiotherapy
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Photodynamic Therapy of Primary Localized Prostate Cancer With the SpectraCure P18 System
The goal of this study is to obtain safety data, establish dose parameters, and effectiveness of treatment for the SpectraCure P18 System with IDOSE®, together with verteporfin for injection (VFI) as photosensitizer, for the…
- Trial name
- NCT06807359
- Testing
- Photodynamic Therapy (PDT), Verteporfin Injection
- Where
- 3 sites in United States, Germany
- Volunteers
- 43 people
- Sponsor
- SpectraCure AB
Prostate Cancer
Experiences With HDR-brachytherapy in Norway
There are 3 articles that will be written about the experience with HDR-brachytherapy (HDR-BT) in patients with high-risk prostate cancer in Norway as part of a doctorial thesis-project.
- Trial name
- NCT03162523
- Testing
- High-Dose Rate Brachytherapy
- Where
- Norway
- Volunteers
- 325 people
- Sponsor
- Oslo University Hospital
Prostate Cancer
Circulating Tumor DNA in High Risk Localized Prostate Cancer
This prospective, non-therapeutic translational biomarker study will collect blood in patients with high risk localized prostate cancer prior to prostatectomy.
- Trial name
- NCT07222436
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pittsburgh