Clinical trials: Localized Cancer
Cancer
Trial of Family Focused Grief Therapy in Palliative Care and Bereavement
The purpose of this study is to learn how well family therapy works if given while a family member is being treated for a serious illness and whether it helps their family to continue meeting for a time after their death.
- Trial name
- NCT00580515
- Testing
- Family Focused Group Therapy, Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Health-Related Quality of Life in Gay Men With Localized Prostate Cancer
RATIONALE: Gathering information about prostate cancer, treatment, and quality of life from gay men with prostate cancer may help doctors plan the best treatment.
- Trial name
- NCT00828633
- Where
- 3 sites in United States, Canada
- Volunteers
- 92 people
- Sponsor
- Baylor College of Medicine
Prostate Cancer
Focal Laser Ablation of Prostate Tissue
This is an open-label pilot, feasibility/exploratory study to evaluate the safety of laser interstitial thermal therapy (LITT) using Visualase in the focal ablation of prostate tissue and to gather data for the design of future…
- Trial name
- FLA (NCT02357121)
- Testing
- Focal Laser Ablation
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Hypopharyngeal Squamous Cell Carcinoma
Toripalimab in Combination With Chemotherapy as Induced Chemotherapy for Localized Hypopharyngeal Cancer
60% of hypopharyngeal cancers were locally advanced at the time of diagnosis. The standard treatment was surgery and postoperative radiotherapy.
- Trial name
- NCT04296747
- Testing
- induction chemotherapy, surgery, chemoradiotherapy
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Prostate Cancer, Prostate Cancer (Adenocarcinoma)
ABlative Radiotherapy (for) Unfavorable Prostate Tumors 2.0
Published clinical evidence confirms that a single dose of 24 Gy provides unprecedented long-term local control in primary and metastatic prostate cancer with safe toxicity profiles, provided that exposure of surrounding healthy…
- Conditions
- Prostate Cancer, Prostate Cancer (Adenocarcinoma), Prostate Cancer Non-Metastatic
- Trial name
- ABRUPT 2 (NCT07407608)
- Testing
- SBRT, SDRT
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- University of Milano Bicocca
Prostate Cancer
Water Vapor Ablation for Localized Intermediate Risk Prostate Cancer
The purpose of this study is to evaluate the safety and efficacy of the Vanquish Water Vapor Ablation Device ("Vanquish") in treating subjects with Gleason Grade Group 2 (GGG2) localized intermediate-risk prostate cancer.
- Trial name
- VAPOR 2 (NCT05683691)
- Testing
- Vanquish System
- Where
- 25 sites in United States
- Volunteers
- 400 people
- Sponsor
- Francis Medical Inc.
Focal Liver Lesions, Ultrasonics
Utility of Ultrasound Imaging for Diagnosis of Focal Liver Lesions: A Radiomics Analysis
Ultrasound (US) as first-line imaging technology in detecting focal liver lesions,also plays a crucial role in evaluating image and guiding ablation which is the main treatment for liver lesions.
- Conditions
- Focal Liver Lesions, Ultrasonics, Intelligent Diagnosis, Ablation
- Trial name
- NCT03871140
- Testing
- diagnosis
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Prostate Cancer
MRI Targeted Focal Laser Thermal Therapy of Biopsy Confirmed Prostate Cancer
The objective of this study is to establish the safety of MRI targeted laser thermal treatment for men with biopsy confirmed early stage low grade single sector prostate cancer.
- Trial name
- NCT00448695
- Testing
- MRI Targeted Focal Thermal Therapy of Prostate Cancer
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Breast Fibroadenoma
Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
This is a monocenter, open-label, uncontrolled study in accordance with §23b MPG to evaluate the efficacy of the HIFU-treatment of fibroadenoma using the TH-One device.
- Trial name
- HIFU (NCT03022695)
- Testing
- High Intensity Focused Ultrasound
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University Hospital Tuebingen
Uterine Fibroids
MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids
This is a prospective, nonrandomized, multi-center study to evaluate the safety and effectiveness of ExAblate in the treatment of uterine fibroids.
- Trial name
- NCT00166270
- Testing
- ExAblate 2000
- Where
- 6 sites in United States
- Volunteers
- 70 people
- Sponsor
- InSightec
Video-assisted Thoracic Surgery, Lung Cancer
Mixed Reality Technique Combined With 3D Printing Navigational Template for Localizing Pulmonary Nodules
This study evaluates the viability and accuracy of preoperative mixed reality technique combined with three-dimensional printing navigational template guided localizing pulmonary small nodules.
- Conditions
- Video-assisted Thoracic Surgery, Lung Cancer, Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
- Trial name
- MR&3D Local (NCT04552054)
- Testing
- Mixed Reality+ 3D printing guided localization, Computerized Tomography guided localization
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Wen-zhao ZHONG
Breast Cancer
Comparison of Two Types of Biopsy in Patients With Breast Lesions
RATIONALE: Biopsy is the removal of cells or tissue for examination under a microscope. It is not yet known which type of breast biopsy is more effective for diagnosing breast lesions.
- Trial name
- NCT00006031
- Testing
- Needle localized breast biopsy with specimen x-ray, Low dose radioactive seed followed by surgery and mammogram
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ganglioneuroblastoma, Localized Resectable Neuroblastoma
Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin
This pilot clinical trial studies induction therapy followed by iobenguane I 131 and chemotherapy in treating patients with newly diagnosed high-risk neuroblastoma undergoing stem cell transplant, radiation therapy, and…
- Conditions
- Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma
- Trial name
- NCT01175356
- Testing
- 3-Dimensional Conformal Radiation Therapy, Autologous Hematopoietic Stem Cell Transplantation, Busulfan
- Where
- 25 sites in United States
- Volunteers
- 99 people
- Sponsor
- Children's Oncology Group
Kidney Tumor, Renal Benign Neoplasm
Renal Mass Biopsy, PEER, and 99mTc-sestamibi SPECT/CT for Patients With Clinically Localized Renal Tumors
The goal of this clinical trial is to better tell apart whether kidney tumors are benign (not cancer) or malignant (cancer) based on a biopsy or imaging tests and ask patients how they feel about decisions they make about…
- Conditions
- Kidney Tumor, Renal Benign Neoplasm, Renal Malignant Tumor
- Trial name
- BIOPSy (NCT05728957)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Localized Osteosarcoma, Metastatic Osteosarcoma
Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma
This research study is studying biomarkers in predicting response to chemotherapy in samples from young patients with osteosarcoma.
- Conditions
- Localized Osteosarcoma, Metastatic Osteosarcoma, Osteoblastic Osteosarcoma, Recurrent Osteosarcoma
- Trial name
- NCT01374672
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
Prostate Cancer
Radiation Therapy Followed by Surgery in High-Risk, Localized Carcinoma of the Prostate
The purpose of the study is to assess the safety of four different doses of radiation therapy followed by to surgery to remove prostate tumor.
- Trial name
- NCT00691977
- Testing
- Radiation Therapy followed by prostatectomy
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Cancer
OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer
RATIONALE: Studying protein expression in sentinel lymph node tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00900302
- Testing
- protein expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- OHSU Knight Cancer Institute
Cancer Cervix
Carrying Out of Focus Group to Improve Cervical Screening Proposal by Vaginal Self-sampling (APACHE-4/FG).
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-4/FG (NCT03420157)
- Testing
- Focus Group
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Prostate Cancer
Study of POMELLA™ Extract to Treat Prostate Cancer
This is a randomized, two-arm, placebo controlled trial to evaluate benefit of treatment using POMELLA™ extract on mechanisms known to drive prostate cancer.
- Trial name
- NCT01100866
- Testing
- POMELLA™ (pomegranate extract)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Vancouver Coastal Health
Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Study of Tumor Samples From Patients With Ewing Sarcoma
This laboratory study is looking at tumor samples from patients with Ewing sarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and…
- Trial name
- NCT00898053
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Oncology Group