Clinical trials: Localized Cancer, open to volunteers
Pancreatic Cancer, Periampullary Cancer
Prehabilitation in Pancreatic Surgery
In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy.
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Frailty Syndrome, Malnutrition
- Trial name
- PIPS (NCT06069297)
- Testing
- Multimodal Prehabilitation
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- IRCCS San Raffaele
ENSAT Stage I Adrenal Cortex Carcinoma, ENSAT Stage II Adrenal Cortex Carcinoma
Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence
This phase III trial studies how well mitotane alone works compared to mitotane with cisplatin and etoposide when given after surgery in treating patients with adrenocortical cancer that has a high risk of coming back…
- Conditions
- ENSAT Stage I Adrenal Cortex Carcinoma, ENSAT Stage II Adrenal Cortex Carcinoma, ENSAT Stage III Adrenal Cortex Carcinoma
- Trial name
- NCT03583710
- Testing
- Cisplatin, Etoposide, Mitotane
- Where
- 33 sites in United States, France and 3 more
- Volunteers
- 240 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Evaluation and Outcomes of SAVI Scout MD for Localized Breast Surgery
The purpose of the study is to evaluate how precise the SAVI Scout MD is and how easy it is for surgeons to use during surgery. The SAVI Scout MD system uses tiny radar reflectors instead of wires, can be placed days or weeks…
- Trial name
- NCT07686250
- Testing
- SAVI Scout MD system
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Prostatic Neoplasms, Prostate Cancer
Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor
Background: The current standard treatment of prostate cancer is either surgery or radiation. Typically, this includes either the removal or radiation of the whole prostate gland.
- Conditions
- Prostatic Neoplasms, Prostate Cancer, Prostate Adenocarcinoma
- Trial name
- NCT05616650
- Testing
- 18F-DCFPyL, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
Carcinoma, Renal Cell
Autologous Dendritic Cell Vaccine in Kidney Cancer
The purpose of this study is to estimate the probability of immune response for the combination treatment of dendritic cell vaccine with oral cabozantinib and characterize the safety profile of interventional therapy.
- Trial name
- NCT05127824
- Testing
- Autologous alpha-DC1/TBVA vaccine, Cabozantinib
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Jodi Maranchie
Prostate Cancer
High-intensity Focused Ultrasound Combined With Novel Hormone Therapy in Advanced Prostate Cancer
The goal of this clinical trial is to explore the feasibility and the synergistic anti-cancer effect of high-intensity focused ultrasound (HIFU) combined with novel hormone therapy (NHT) in advanced prostate cancer (PCa).
- Trial name
- HIFU NHT PCa (NCT07126093)
- Testing
- focal high-intensity focused ultrasound therapy combined with standard novel hormonal therapy, Standard novel hormonal therapy only
- Volunteers
- 134 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pancreatic Cancer, Borderline Resectable Pancreatic Cancer
Chemotherapy With or Without IMD10 (Focused Ultrasound) in the Treatment of Borderline Resectable or Locally Advanced Pancreatic Cancer
The purpose of this Interventional clinical trial is to evaluate safety and efficacy of 'IMD10 (focused ultrasound)' in the treatment of borderline resectable pancreatic cancer or locally advanced pancreatic cancer.
- Conditions
- Pancreatic Cancer, Borderline Resectable Pancreatic Cancer, Locally Advanced Pancreatic Cancer
- Trial name
- SonoPANIII (NCT07325214)
- Testing
- IMD10, chemotherapy regimen [irinotecan hydrochloride, oxaliplatin, fluorouracil (5-FU) and leucovorin]
- Where
- 5 sites in United States, South Korea
- Volunteers
- 360 people
- Sponsor
- IMGT Co., Ltd.
Cutaneous Melanoma, Stage III, Mucosal Melanoma
Neo-adjuvant Immunotherapy in Patients With Localized Melanoma
The success of anti-PD-1 and anti-CTLA-4 therapies has initiated a paradigm shift in oncology, with drugs now targeting the immune system rather than cancer cells to stimulate the antitumor immune response.
- Trial name
- NEOREM-NEO-1 (NCT07230613)
- Testing
- Ipilimumab (YervoyTM, 50 mg/10 mL solution), Nivolumab (OpdivoTM, 40 mg/4mL solution)
- Where
- 6 sites in France
- Volunteers
- 50 people
- Sponsor
- UNICANCER
Prostate Cancer, Laser
Focal Laser Ablation in Prostate Cancer
To assess the effectiveness of MRI-US or PSMA PET/CT-U/S fusion-guided focal laser ablation (FLA) for the treatment of a localized, intermediate-risk prostate cancer in terms of short-term oncological \& functional outcomes.
- Trial name
- NCT06916013
- Testing
- Focal laser ablation
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate
RYZ711 Diagnostic Platform Study
This is a Phase 1/2 multicenter, multi-cohort imaging study to evaluate the safety, tolerability, and diagnostic performance of RYZ711 positron emission tomography/computed tomography (PET/CT) in men with histologically confirmed…
- Conditions
- Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate, Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT07862582
- Testing
- RYZ711, PSMA PET/CT
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- RayzeBio, Inc.
Localized Prostate Carcinoma, Locally Advanced Prostate Carcinoma
Golf Recreational Exercise for Enhanced Survivorship in Prostate Cancer Survivors
This clinical trial evaluates a golf recreational exercise program for enhancing survivorship in underrepresented prostate cancer survivors.
- Conditions
- Localized Prostate Carcinoma, Locally Advanced Prostate Carcinoma, Stage I Prostate Cancer American Joint Committee on Cancer (AJCC) v8, Stage II Prostate Cancer AJCC v8
- Trial name
- GREENS (NCT06500169)
- Testing
- Biospecimen Collection, Discussion, Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Any Cancer
PROACT is a Prospective Master Protocol for a Cohort Study Focused on Evaluating the Implementation of Integrated Proactive Supportive Care Pathways at Gustave Roussy
PROACT is a prospective master protocol for a cohort study focused on evaluating the implementation of integrated proactive pathways of supportive care.
- Trial name
- PROACT (NCT06479057)
- Testing
- Supportive Care Pathway
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Non Small Cell Lung Cancer, Metastatic Lung Cancer
Vapor Ablation for Localized Cancer Lesions
This study is a prospective, single-arm, multi-center, pilot trial of Bronchoscopic Thermal Vapor Ablation for Lung Cancer (BTVA-C) in patients with primary lung cancer or metastatic cancer in the lung.
- Conditions
- Non Small Cell Lung Cancer, Metastatic Lung Cancer, Lung Cancer
- Trial name
- VAPORIZED (NCT03514329)
- Testing
- Bronchoscopic Thermal Vapor Ablation
- Where
- 2 sites in Austria, Italy
- Volunteers
- 10 people
- Sponsor
- Uptake Medical Technology, Inc.
Histologically Confirmed Localized Prostate Cancer, Scheduled to Undergo Robot-assisted Radical Prostatectomy With Planned Unilateral or Bilateral Nerve-sparing Surgery
Neurovascular Bundle Stimulation During Robot-Assisted Radical Prostatectomy
This prospective first-in-human feasibility study will evaluate the safety and feasibility of selective electrical stimulation of the neurovascular bundles (NVBs) during nerve-sparing robot-assisted radical prostatectomy (RARP).
- Trial name
- NVB Stym-RARP (NCT07724028)
- Testing
- Selective Neurovascular Bundle Stimulation Probe
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Progressive Glioblastoma, Recurrent Glioblastoma
Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
This early phase I trial tests the safety, best dose, and effectiveness of SONALA-001 or 5-ALA HCL in combination with magnetic resonance imaging-guided focused ultrasound (MRgFUS), also called sonodynamic therapy, in treating…
- Trial name
- NCT07076472
- Testing
- Aminolevulinic Acid Intravenous Formulation SONALA-001, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Advanced Cancer
Development and Pilot Trial of Focused ACT (FACT) for Patients With Advanced Cancer
To learn about the effects of an intervention program called Focused Acceptance and Commitment Therapy (FACT) on the level of anxiety patients diagnosed with cancer feel about death.
- Trial name
- NCT07105033
- Testing
- FACT Session, Enhanced Usual Care and Assessments
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Neoplasm Malignant, Body Weight
Body Mass Index (BMI) and Quality of Life (QoL) in Cancer Patients
BMI is a simple and widely recorded variable that may capture obesity or cachexia in cancer patients. How BMI is associated to health-related quality of life (HR-QoL) in such patients is poorly investigated.
- Conditions
- Neoplasm Malignant, Body Weight, Quality of Life
- Trial name
- BMI-QoL (NCT03873064)
- Where
- Italy
- Volunteers
- 1,380 people
- Sponsor
- University of Rome Tor Vergata
High-risk Localized Prostate Cancer
A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer.
Researchers are looking for a better way to treat men who have high-risk localized prostate cancer, which refers to a type of prostate cancer that is still confined to the prostate gland but has certain characteristics that make…
- Trial name
- CHINANEO (NCT07450599)
- Testing
- Darolutamide, ADT
- Where
- 23 sites in China
- Volunteers
- 250 people
- Sponsor
- Bayer
Chordoma
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease
Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma
- Trial name
- SACRO (NCT02986516)
- Testing
- Randomized Cohort, Prospective cohort
- Where
- 28 sites in Austria, Germany and 8 more
- Volunteers
- 100 people
- Sponsor
- Italian Sarcoma Group
Prostate Cancer, Prostate Neoplasm
Effectiveness of Focal Therapy in Men With Prostate Cancer
In the Netherlands, most men with prostate cancer (PCa) are treated with radical whole-gland treatment, i.e. prostatectomy or radiotherapy.
- Trial name
- ENFORCE (NCT06223295)
- Testing
- Focal therapy, Usual care
- Where
- 5 sites in Netherlands
- Volunteers
- 356 people
- Sponsor
- Radboud University Medical Center