Clinical trials: Localized Infection
Virus Diseases
Post-COVID-19 Monitoring in Routine Health Insurance Data With Focus on Autoimmune Diseases (POINTED-AD)
The SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) infection was in 2020 responsible for new disease related chronic conditions which have been referred to as Post-COVID.
- Trial name
- POINTED-AD (NCT05606198)
- Testing
- Exposed to a SARS-CoV-2 infection
- Where
- Germany
- Volunteers
- 641,407 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Malaria
Human Mass Balance Study of Pyronaridine
The combination of pyronaridine and artesunate is an antimalarial therapy in development. This mass balance study is intended to determine the rate and extent of excretion of total radioactivity in urine and feces following…
- Trial name
- NCT01383109
- Testing
- 14C-labeled Pyronaridine
- Where
- Switzerland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Patients Post-COVID-19, Controls
Sequelae of COVID-19 With Focus on Exercise Capacity and Underlying Mechanisms
The project is designed as a cross-sectional study and aims to examine long-term consequences of coronavirus disease 2019 (COVID-19) for selected bio-behavioural parameters while taking the disease course severity into account.
- Trial name
- COR-PHYS (NCT05118711)
- Testing
- Cardiorespiratory fitness, Lung function, Muscular strength and balance tests
- Where
- Switzerland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Arno Schmidt-Trucksäss
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Anemia, Hematologic Diseases
Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease
The purpose of this study is to compare liberal red blood cell transfusion therapy with restrictive red blood cell transfusion therapy in surgical patients with cardiovascular disease or risk factors.
- Conditions
- Anemia, Hematologic Diseases, Cardiovascular Diseases, Heart Diseases
- Trial name
- FOCUS (NCT00071032)
- Testing
- Liberal (10 g/dL) Transfusion Strategy, Restrictive (Symptomatic) Transfusion Strategy
- Where
- United States
- Volunteers
- 2,016 people
- Sponsor
- Rutgers, The State University of New Jersey
HIV-Associated Focal Segmental Glomerulosclerosis, HIV-Associated Collapsing Glomerulopathy
Evaluation of Albuminuria HIV-Infected Patients
This study will examine the following: 1) how common albuminuria and proteinuria are among HIV-positive patients, 2) what causes albuminuria or proteinuria in these patients and 3) whether the condition becomes more severe over…
- Conditions
- HIV-Associated Focal Segmental Glomerulosclerosis, HIV-Associated Collapsing Glomerulopathy, Proteinuria, Albuminuria
- Trial name
- NCT00524992
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
HIV Infections, Substance Use
Women Focused Encounters for Resilience Independence Strength and Eudaimonia
The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance…
- Conditions
- HIV Infections, Substance Use, Trauma, Medication Adherence
- Trial name
- WE RISE (NCT06216600)
- Testing
- Acceptance and Commitment Therapy (ACT), Body weight circuit training, Empathetic social support
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cutaneous Leishmaniasis
Local Heat Therapy Versus Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasis
This study serves to compare the effectiveness of treating cutaneous leishmaniasis with either intravenous sodium stibogluconate or direct heat therapy using the ThermoMed-TM device.
- Trial name
- NCT00884377
- Testing
- Sodium stibogluconate (Pentostam), ThermoMed
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- U.S. Army Medical Research and Development Command
Multi-resistant Gram-negative Bacteria Cause Infection
GRAM NEGATIVES STUDY
This is a prospective, observational, multicenter study whose main objective is to develop a predictive model of mortality in critically ill patients colonized by multidrug-resistant Gram-negative bacteria (MDR-GNB).
- Trial name
- MR-GEIPC (NCT07749508)
- Testing
- Standard of care therapy
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Fundacion SEIMC-GESIDA
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
COVID-19 Pandemic
COVID-19 Testing and Vaccine Literacy for Women With Criminal Legal System Involvement
The objective of this research is to use a localized mHealth intervention to boost COVID-19 testing and vaccine literacy, access, and uptake among women with CLSI
- Trial name
- COVID-19 (NCT05582746)
- Testing
- Tri-City COVID Attitudes Study
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hepatitis C, Chronic
ATTIC - Access To Treat in the Community
The study is looking at the potential of utilizing a "point of care" test and treat pathway; using the DDA called Zepatier for achieving SVR in an homeless population who have tested positive for genotype 1 or 4 HCV.
- Trial name
- ATTIC (NCT03797066)
- Testing
- ZEPATIER 50Mg-100Mg Tablet
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- King's College Hospital NHS Trust
Clostridium Difficile Infections
Molecular Epidemiology of Clostridium Difficile Infections in Children
Objectives: 1. Describe the molecular epidemiology of Clostridium Difficile infection in children in the Chicago area. 2. Determine the clinical spectrum and risk factors for Clostridium Difficile infection secondary to…
- Trial name
- NCT01957761
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Schistosomiasis
Women and Children as the Focus for Control of Schistosomiasis Infections in the Irrigations Area of Burkina Faso
The purpose of this study is to examine the extent of schistosomasis infections in women and children, their daily activites that encumber contact with water and their knowledge and attitudes towards the prevention of…
- Trial name
- NCT00463528
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
MSM, HIV Infections
Risk Taking Behaviour in MSM and the Denial of Sexually Transmitted Diseases and HIV
Four focus groups , each of 10-15 males, ages 20-50 years old, MSM will be conducted by a medical sociologist. Two groups will be HIV negative participants and two groups of HIV positive MSM. Every group will meet for two hours.
- Conditions
- MSM, HIV Infections, Risky Behaviors
- Trial name
- MSM HIV (NCT01279005)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Mycobacterium Avium Intracellulare Complex (MAC)
Mycobacterium Avium Intracellulare Complex (MAC) Study
This study is short course (3 month) multiple drug antibiotic therapy. The purpose of this research study is to evaluate the clinical and radiology response to assess whether drug resistance develops and assess quality of life…
- Trial name
- MAC (NCT00826423)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Trachoma
Trachoma Elimination Study by Focused Antibiotic (TESFA)
The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured…
- Trial name
- NCT03523156
- Testing
- Azithromycin mass treatment, Azithromycin targeted treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Merkel Cell Polyomavirus Infection, Stage IV Merkel Cell Carcinoma AJCC v7
Localized Radiation Therapy or Recombinant Interferon Beta and Avelumab With or Without Cellular Adoptive Immunotherapy in Treating Patients With Metastatic Merkel Cell Carcinoma
This phase I/II trial studies the side effects and how well localized radiation therapy or recombinant interferon beta and avelumab with or without cellular adoptive immunotherapy works in treating patients with Merkel cell…
- Trial name
- NCT02584829
- Testing
- Avelumab, Laboratory Biomarker Analysis, MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Fred Hutchinson Cancer Center
Health Risk Behaviors
Sexually Active Adolescent Focused Education
SAAFE will be pilot tested in 2 geographically distinct areas (Washington, DC and Deep South) with 100 participants from each site to 1) primarily assess the efficacy of improved self-efficacy, knowledge about HIV/STIs and…
- Trial name
- SAAFE (NCT03646032)
- Testing
- SAAFE, Control
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Benten Technologies, Inc.
Liver Neoplasms, Adenoma
Liver MRI With Primovist/Eovist in Pediatric Subjects Who Are Suspected or Have Focal Liver Lesions.
Medical records are reviewed to obtain information about the use of a MRI diagnostic imaging agent (contrast agent) called Primovist/Eovist in children older than 2 months and less than 18 years.
- Conditions
- Liver Neoplasms, Adenoma, Carcinoma, Liver Abscess
- Trial name
- NCT01043523
- Testing
- Gadoxetic Acid Disodium (Eovist, BAY86-4873)
- Where
- 9 sites in United States, Italy and 3 more
- Volunteers
- 52 people
- Sponsor
- Bayer