Clinical trials: Locomotion Disorder, Neurologic
Parkinson Disease
Effect of Adding Computerized Cognitive Training on Balance, Locomotion and Cognition in Parkinson's Disease
BACKGROUND: Postural instability and gait abnormalities are cardinal features in Parkinson's disease (PD). It represents one of the most disabling symptoms in the advanced stages of the disease.
- Trial name
- NCT06104072
- Testing
- REHACOM Software, A Designed Physical Therapy Program
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Engy Badreldin Saleh Moustafa, PhD
Alzheimer Disease
Influence of Physical Exercise as Adjuvant Treatment in Patients With Alzheimer's Disease
The goal of this non-randomized clinical trial is to assess the effects of strength training in the physical function of Alzheimer's disease (AD) patients. The main question it aims to answer are: 1.
- Trial name
- NCT05862935
- Testing
- Supervised Physical Activity (AMRAP -As Many Repetitions As Possible): Phase 2, Supervised Physical Activity: Phase 1
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- European University Miguel de Cervantes
Craniocerebral Trauma
The Acute Effect of Boxing on Balance, Neuropsychological, and Visual Functions
Prior research has investigated the effect of repetitive head trauma as it relates to physiological and psychological function. Boxing is one particular sport which predisposes athletes to a large amount of head impacts.
- Trial name
- NCT02442882
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Brain Concussion, Musculoskeletal Injury
A Sports Injury Prevention Program to Reduce Subsequent Injuries After Concussion
The long-term goal of this research is to implement methods that healthcare providers can use across diverse clinical settings to (1) identify athletes at risk for (musculoskeletal) MSK injury when cleared to return to play (RTP)…
- Conditions
- Brain Concussion, Musculoskeletal Injury, Locomotion, Postural Balance
- Trial name
- NCT03917290
- Testing
- Neuromuscular training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Movement Disorders, Neurorehabilitation
Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants
Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG)…
- Conditions
- Movement Disorders, Neurorehabilitation, Non-invasive Activity Recording
- Trial name
- NCT07236892
- Testing
- Participants will perform experimental tasks while undergoing non-invasive activity recordings, which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stroke Sequelae, Gait, Hemiplegic
ACTive Exoskeleton for Unilaterally-Assisted Locomotion (ACTUAL)
Walking difficulties are common symptoms after stroke, significantly reducing quality of life. Walking recovery is therefore one of the main priorities of rehabilitation.
- Trial name
- ACTUAL (NCT06061601)
- Testing
- Exoskeleton stroke group
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Spinal Cord Injury
Robotic-assisted Locomotor Training on Mobility and Cardiopulmonary Function in Patients Suffering From Spinal Cord Injury
Evidences showed that patients suffering from spinal cord injury (SCI) have poor mobility and higher chance to develop cardiopulmonary diseases, which leads to poor quality of life and shorter life expectancy.
- Trial name
- NCT01989806
- Testing
- Robotic-assisted body weight supported treadmill training (Lokomat V6, Hocoma AG, Switzerland), Passive lower limbs mobilization training (Motomed Vivo 2, RECK, Germany)
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Kowloon Hospital, Hong Kong
Brain Concussion
Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion
Previous research and position statements have outlined the necessity of balance and gait testing in the post-concussion evaluation of athletes.
- Trial name
- NCT02317107
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Movement Disorders, Parkinson Disease
A Smartphone Based, Titrated Exercise Solution for Patients With Parkinson's Disease in Daily Life: Pilot Study
The aim of this pilot randomized controlled trial is to test whether it's feasible to increase participants' step counts within four weeks with a developed motivational smartphone application.
- Trial name
- STEPWISE (NCT06692387)
- Testing
- Step count increase with the use of a motivational application
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Stroke, Chronic Stroke
Optimizing Training in Severe Post-Stroke Walking Impairment
Difficulty walking is common after a stroke. Although physical rehabilitation helps a little with the improvement of walking ability, recovery is usually incomplete.
- Conditions
- Stroke, Chronic Stroke, Walking, Difficulty, Gait, Hemiplegic
- Trial name
- BLT2b (NCT04721860)
- Testing
- Backward Locomotion Treadmill Training (BLTT), Forward Locomotion Treadmill Training (FLTT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Spinal Cord Injuries
Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury
The purpose of this study is to collect data comparing two means of providing locomotor training: manual and robotic and the possible differential effects it may have on walking ability for persons with spinal cord injury (SCI).
- Trial name
- DE (NCT00127439)
- Testing
- Manually Assisted Locomotor Training, Robotic Assisted Locomotor Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Transformation of Paralysis to Stepping
The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis.
- Trial name
- NCT04105114
- Testing
- Buspirone, Non-invasive Spinal Cord Stimulation, Overground stepping
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Parkinson Disease
Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.
Parkinson Disease (PD) patients experience a variety of motor issues such as walking difficulties, loss of balance, and freezing while walking, which impacts their quality of life.
- Trial name
- SCS for FOG (NCT03526991)
- Testing
- Spinal Cord Stimulator (SCS)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Nora Vanegas
Locomotion Disorder, Neurologic
Non Motoric Reactions in Vojta Reflex Locomotion
Monitoring of non-motor manifestations of reflex locomotion according to Professor Vojta in laboratory conditions on healthy woman probands.
- Trial name
- VojtaRL (NCT06224491)
- Testing
- Reflex locomotion according to Vojta
- Where
- Czechia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Exoskeleton Device, Locomotion
Investigation of the Effects of Robot Assisted Gait Training With Virtual Reality on Cognitive Functions in Stroke Patients
It was planned to examine the effects of robot-assisted walking training supported by virtual reality on cognitive functions, quality of life and activities of daily living in individuals with subacute stroke.
- Conditions
- Exoskeleton Device, Locomotion, Stroke
- Trial name
- NCT05614141
- Testing
- Lokomat Augmented Performance Feedback, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara Yildirim Beyazıt University
Parkinson's Disease
Effects of Exercise on Long-Range Autocorrelations in Parkinson's Disease
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The parkinsonian gait is characterized by reducted stride length and gait speed, postural disorders (with a high risk of falling) and a modification…
- Trial name
- NCT02419768
- Testing
- Physical Exercise
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Stroke
Constraint Induced Movement Therapy for Walking in Individuals Post Stroke
To compare the effect of constraint induced movement therapy (CIMT) vs. treadmill training only on walking function in individuals post-stroke, a 6 week, single-blind, randomized training study will be conducted with three…
- Trial name
- NCT03264261
- Testing
- robotic training, treadmill training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Noninvasive Spinal Stimulation in Stroke
This is a randomized control trial that will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
- Trial name
- NCT03714282
- Testing
- Noninvasive spinal stimulation with gait training, Conventional gait training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Overground Walking Program With Robotic Exoskeleton in Long-term Manual Wheelchair Users With Spinal Cord Injury
Many individuals with a spinal cord injury (SCI) use a wheelchair as their primary mode of locomotion. The prolonged non-active sitting time associated to this mode of locomotion contributes to development or worsening of…
- Trial name
- NCT03989752
- Testing
- Wearable Robotic Exoskeleton for Ambulation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal