Clinical trials: Locomotor Activity
Stroke
Noninvasive Spinal Stimulation in Stroke
This is a randomized control trial that will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
- Trial name
- NCT03714282
- Testing
- Noninvasive spinal stimulation with gait training, Conventional gait training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Overground Walking Program With Robotic Exoskeleton in Long-term Manual Wheelchair Users With Spinal Cord Injury
Many individuals with a spinal cord injury (SCI) use a wheelchair as their primary mode of locomotion. The prolonged non-active sitting time associated to this mode of locomotion contributes to development or worsening of…
- Trial name
- NCT03989752
- Testing
- Wearable Robotic Exoskeleton for Ambulation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Lower Limb Amputation
Exploratory Functional Assessment After Lower Limb Amputation: Locomotion, Balance, Energy Performance and Strategies for Adapting to Orthopaedic Devices
The general aim of this exploratory study is therefore to investigate and quantify the functional capacities of patients with lower limb amputations (transtibial and transfemoral), with no change in their management, and to…
- Trial name
- AMILOCO (NCT07094074)
- Testing
- Walk tests, Functional testing, Balance analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Parkinson Disease, Gait Disorders
Effects of Biofeedback Footwear in Parkinson's Disease: Assessment of Functional Motor Abilities and Locomotion
The study aims to verify whether the use of a specific footwear providing increased plantar feedback (plantar feedback shoes) could improve gait parameters, postural control and functional performances in people with Parkinson's…
- Trial name
- NCT06453863
- Testing
- Greater plantar feedback shoes, Neutral gym shoes, Barefoot
- Volunteers
- 40 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cerebral Palsy
Intensive Activities-based Locomotor Training Program in Children With Cerebral Palsy
The goal of the proposed work is to investigate the impact of an intensive 3-week activities-based locomotor training (AB-LT) program on activity capacity, activity performance, and participation in children with cerebral palsy…
- Trial name
- NCT05867628
- Testing
- Activities-based locomotor training (physical therapy)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor University
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Chronic Low-back Pain, Walking
Locomotion Strategies of Low Back Pain Patients in a Dynamic Environment
The biomechanical parameters studied in non-specific chronic low back pain patients in a locomotion task have so far focused on straight line walking.
- Trial name
- NCT05851118
- Testing
- Quantified analysis of walking during a crossing task between two walkers
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rennes 2
Healthy, Spastic Hemiparesis
Soleus Loading Response During Walking
Stroke survivors experience motor deficits, weak voluntary muscle activations, and low weight-bearing capacity that impair ambulation.
- Conditions
- Healthy, Spastic Hemiparesis, Stroke
- Trial name
- NCT05436366
- Testing
- Soleus loading response in able-bodied participants, Soleus loading response in participants with hemiparesis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Victor H. Duenas
Chronic Paraplegia
Training With Brain-machine Interfaces, Visuo-tactile Feedback and Assisted Locomotion for Patients With Chronic Complete Paraplegia
The purpose of this research is to compare the effectiveness of a training protocol integrating Brain-machine Interfaces, Visuo-tactile feedback and Assisted Locomotion (referred to as the Walk Again Neurorehabilitation protocol…
- Trial name
- NCT03992690
- Testing
- Brain-machine Interfaces, Visuo-tactile Feedback and Assisted Locomotion, or the WANR protocol, Training with traditional physiotherapy protocol
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Cord Injury
Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury
As a first-in-class (Central Pattern Generator or CPG activator) approach, this tritherapy candidate called SPINALON has been identified and is currently under development for its capacity to temporarily induce episodes of…
- Trial name
- NCT01484184
- Testing
- SPINALON (buspirone + levodopa + cardidopa)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nordic Life Science Pipeline Inc.
Traumatic Amputation of Lower Extremity
Characterizing Ankle Function During Sloped Locomotion for Prosthesis Development
The proposed study aims to characterize biological ankle joint function during walking and running on slopes in order to further develop advanced powered ankle-foot prostheses.
- Trial name
- NCT01784003
- Testing
- Powered ankle-foot prosthesis
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Multiple Sclerosis, Physical Therapy
Vojta Therapy in Multiple Sclerosis.
This Study evaluates the effectiveness of a Vojta locomotion reflex program as short-term automatic postural control in patients with Multiple sclerosis
- Trial name
- NCT03887507
- Testing
- Vojta Therapy, Standard Program
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- NUMEN Foundation
Alzheimers Disease, Mild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor…
- Trial name
- NCT06484244
- Testing
- 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Stroke, Locomotion Disorder, Neurologic
The Effect of Using Walking Aid On TUG Test
The Timed Up and Go Test is a measurement tool that allows the participant to use assistive devices and walking aids during the test that evaluates functional mobility.
- Trial name
- NCT05997472
- Testing
- evaluation af mobility and balance
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Bandırma Onyedi Eylül University
Gait, Locomotion
Effects of Heel Height on Gait Parameters
This observational study aims to investigate the effects of different shoe heel heights on gait parameters and pelvic kinematics in healthy adults aged 18-35 years.
- Trial name
- NCT07167472
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amputation
Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees
The purpose of this study is to develop a robust, low-power, stable, and light weight, active knee prosthetic device that can dramatically increase gait symmetry and walking economy of a transfemoral amputee during walking.
- Trial name
- NCT00771589
- Testing
- Active Knee Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Providence VA Medical Center
Stroke
Moderate-Intensity Exercise Versus High-Intensity Interval Training to Recover Walking Post-Stroke
The objective of this study is to determine the optimal training intensity and the minimum training duration needed to maximize immediate improvements in walking capacity in chronic stroke.
- Trial name
- NCT03760016
- Testing
- Moderate-Intensity Aerobic Training, High-Intensity Interval Training
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Cincinnati
Stroke
Impaired Interlimb Coordination During Locomotion in Individuals With Chronic Stroke: Contributors and Effect on Walking Function
Individuals with chronic stroke have long-term walking problems that limit community engagement and quality of life, lead to secondary disabilities, and increase healthcare costs and burden.
- Trial name
- NCT07006818
- Testing
- Direct current stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Type 2 Diabetes Mellitus
Impact of Muscle and Tendon Dysfunction in People With Type 2 Diabetes Mellitus
Diabetes is a chronic-degenerative metabolic disorder that has reached pandemic proportions mainly because of the increasing incidence and prevalence of type 2 diabetes mellitus (T2D).
- Trial name
- T2D_MTU (NCT05585502)
- Testing
- Training (minute oscillation stretching)
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Spinal Cord Injury
Xo-Motion R Exoskeleton in SCI-Adoption Study
After spinal cord injury (SCI), many people lose their ability to walk and do not have access to equipment and assistance that could help them regain functional abilities.
- Trial name
- NCT07380516
- Testing
- XoMotionR- assisted locomotor training
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta