Clinical trials: Locoregional Anaesthesia
Lung Cancer, Thoracic Surgery
Epidural Anesthesia-analgesia and Long-term Survival After Lung Cancer Surgery
Available studies suggest that regional anesthesia-analgesia may decrease the occurrence of recurrence/metastasis in patients after cancer surgery. However, evidences from prospective studies are still lacking.
- Conditions
- Lung Cancer, Thoracic Surgery, Anesthesia, Epidural, Neoplasm Recurrence, Local
- Trial name
- NCT02801409
- Testing
- General anesthesia alone, Combined epidural-general anesthesia
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University First Hospital
Ultrasound Imaging of Anatomical Structures
Validity of Experts and ScanNav Anatomy PNB When Identifying Sono-anatomical Structures for Ultrasound-Guided Regional Anaesthesia
This is a multi-centre, prospective, observational study, conducted under the auspices of the University of Oxford to evaluate ultrasound image analysis by human experts and an artificial intelligence device in the context of…
- Trial name
- NCT04983771
- Testing
- Annotate ultrasound scans
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- IntelligentUltrasound Limited
Dental Anxiety, Dental Pain
Comfort-in Needle-Free Injection System in Pediatric Dental Anesthesia
This randomized split-mouth clinical trial evaluated the efficacy of the Comfort-in needle-free injection system compared with conventional dental injection for local anesthesia during pulpotomy treatment in children.
- Conditions
- Dental Anxiety, Dental Pain, Pulpotomy, Local Anesthesia
- Trial name
- NCT07585812
- Testing
- Comfort-in Needle-Free Injection System, Conventional Dental Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
General Anesthesia, Surgeries Requiring A Minimum One Day Hospitalization
How Lidocaine Affects Outcomes In Orthopedic Surgery Patients
This study will evaluate the effect of intraoperative lidocaine infusion on postoperative orientation and concentration in elderly patients having general anesthesia for orthopedic surgeries requiring a minimum 2 days…
- Conditions
- General Anesthesia, Surgeries Requiring A Minimum One Day Hospitalization, Elderly
- Trial name
- NCT01179100
- Testing
- Lidocaine
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Anesthesia
Comparison of Time and Cost Efficiency in Arthroscopic Shoulder Surgery Under Regional Anesthesia vs General Anesthesia
Arthroscopic Shoulder surgery can be done not only under general anesthesia but also regional technics. In this study we aimed to compare the cost and time effectiveness of regional anesthesia and general anesthesia.
- Trial name
- vs (NCT05563025)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Samsun University
Abdominal Cancer, Abdominal Pain
Safety and Efficacy of Intrathecally Administered Magnesium Sulfate
Magnesium sulfate safety profile has been documented by histopathological analysis in experimental studies. magnesium sulfate added to local anesthetics decrease postoperative opioid requirements.
- Trial name
- NCT03459417
- Testing
- intrathecal morphine+LA, intrathecal morphine+LA+ Mg sulp. 50, intrathecal morphine+LA+ Mg sulp. 100
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- South Egypt Cancer Institute
Ankle Fractures
Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures
The investigators plan to evaluate the efficacy in reducing post-operative pain between local multimodal analgesia as compared to regional anesthesia in rotational ankle fractures.
- Trial name
- NCT05019638
- Testing
- Regional anesthesia group, Local multimodal analgesia group
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Jejunostomy, Gastrostomy
Anesthesia Management and Perioperative Outcomes in Awake Jejunostomy and Gastrostomy
Patients requiring surgical jejunostomy or gastrostomy often have advanced malignancy, multiple comorbidities, and limited physiological reserve, which may increase the risks associated with general anesthesia.
- Conditions
- Jejunostomy, Gastrostomy, Anesthesia, Regional
- Trial name
- Awake Jejunost (NCT07885358)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Samsun University
Anesthesia, Anesthesia, Local
A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade
Neosaxitoxin is a new compound that is in clinical development as local anesthetic for surgical anesthesia and postoperative analgesia.
- Conditions
- Anesthesia, Anesthesia, Local, Analgesia
- Trial name
- NCT03399435
- Testing
- Neosaxitoxin combined with bupivacaine low and epinephrine (T1), Bupivacaine low combined with epinephrine (C1), Bupivacaine high combined with epinephrine (C2)
- Where
- Netherlands
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Anesthesia
URAISE: Ultrasound Regional Anaesthesia Interpretation Skill Evaluation
Prospective study based on psychometric principles.# To generate a validated test of ultrasound guided regional anaesthesia that can used to differentiate reliably between users of different skill levels.
- Trial name
- URAISE (NCT05668689)
- Testing
- Preliminary testing, Psychometric main study testing (Phase 5)
- Where
- 6 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Rheumatological Injection, Pain Management
The Value of Standardized Respiratory Rate Monitoring Exercises During Rheumatological Injection Procedures
The goal of this clinical trial is to demonstrate the non-inferiority of standardized breathing control exercises on perceived pain during rheumatological injections procedures compared to standard care consisting of the addition…
- Conditions
- Rheumatological Injection, Pain Management, Respiratory Monitoring
- Trial name
- Respi-IR (NCT07172984)
- Testing
- Anesthesia, breathing group
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Hip Arthroplasty
Anesthetic Methods and Gene Expression Profile
The study will analyze differentially regulated genes involved in oxidative stress and toxicology in peripheral blood mononuclear cells (PBMCs) of patients who underwent arthroplasty under three different anesthetic methods.
- Trial name
- GeSTA (NCT03585647)
- Testing
- hip arthroplasty
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- University of Bologna
Postoperative Pain, Cardiac Surgery
ASPB-PIPB Combination in Cardiac Surgery
Cardiopulmonary bypass surgery is associated with significant postoperative pain, which may adversely affect respiratory function, delay mobilization, prolong hospital stay, and increase postoperative complications.
- Conditions
- Postoperative Pain, Cardiac Surgery, Cardiopulmonary Bypass, Median Sternotomy
- Trial name
- NCT07716943
- Testing
- Combined ASPB and PIPB, Anterior Serratus Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Regional Anesthesia Block
A Comparing Transversalis Fascia Plane Block and Quadratus Lumborum Block for Post-Cesarean Pain Management: Efficacy, Execution Time, and Practicality
Transversalis Fascia Plane Block (TFPB) and Quadratus Lumborum Block (QLB) provide superior analgesia to Transversus Abdominis Plane Block (TAPB) for post-cesarean pain management.
- Trial name
- NCT06874569
- Testing
- TAP Block:, TFP Block:, QLB:
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Aswan University
Hip Fractures
Regional Versus General Anesthesia for Promoting Independence After Hip Fracture
The purpose of this study is to find out if two types of standard care anesthesia are the same or if one is better for people who have hip fractures.
- Trial name
- REGAIN (NCT02507505)
- Testing
- Regional Anesthesia, General Anesthesia
- Where
- 45 sites in United States, Canada
- Volunteers
- 1,848 people
- Sponsor
- University of Pennsylvania
Anesthesia, Anesthesia, Local
Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children
Circumcision is one of the most commonly performed operations in the pediatric population and is a painful procedure. Circumcision is performed with two popular techniques, Plastibell and conventional dissection method (CDM).
- Conditions
- Anesthesia, Anesthesia, Local, Analgesia, Pediatric ALL
- Trial name
- NCT05233683
- Testing
- Caudal block, Dorsal penile nerve block plus ring block, Circumcision with Plastibell
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- King Saud University
Pulpitis
Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With Pulpitis
The objective of this clinical trial is to evaluate whether buffered local anesthesia is more effective than conventional local anesthesia in reducing pain responses in school-aged children requiring dental treatment for…
- Trial name
- NCT07638254
- Testing
- Buffered Lidocaine with Epinephrine, idocaine with Epinephrine (Conventional)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Anesthesia
What Effect Does Intubation Have on Regional Lung Ventilation?
During any general anaesthetic which involves muscle relaxation artificial breathing is required. This is most commonly provided by pushing air under pressure (positive pressure ventilation) into the lungs via a tube in the…
- Trial name
- NCT03319303
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Shoulder Cuff Surgical Repair
Rotator Cuff Repair Under Isolated Loco-regional Anesthesia
Damage to the tendons of the shoulder, called rotator cuff, causes pain and loss of strength that may require surgery. This operation is performed under general anesthesia combined with loco-regional anesthesia of the shoulder.
- Trial name
- AGORA (NCT05848375)
- Testing
- Arthroscopic rotator cuff repair, naropeine or chirocaine (Arthroscopic rotator cuff repair under LRA associated to GA), naropeine or chirocaine (Arthroscopic rotator cuff repair under LRA)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Elsan
Sciatic Nerve Blockade for Foot/Ankle Surgery
Circumferential Spread of Anesthetic and Success in Sciatic Nerve Blockade
Current practices when performing any peripheral nerve block may or may not involve ensuring circumferential spread of local anesthetic around the nerve.
- Trial name
- NCT00802581
- Testing
- Circumferential spread of local anesthetic, Non-circumferential spread of local anesthetic
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University Health Network, Toronto
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