Clinical trials: Locoregional Neoplasm Recurrence
Nasopharyngeal Carcinoma, Local Recurrence
MRG003 Induction and Capecitabine Maintenance With PD-1 in Locally Recurrent NPC
This study enrolls patients who have experienced local recurrence of nasopharyngeal carcinoma (NPC) with or without regional recurrence.
- Trial name
- NCT07331428
- Testing
- MRG003, Tislelizumab, Capecitabine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fujian Cancer Hospital
Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma
TLR9 Agonist SD-101, Ibrutinib, and Radiation Therapy in Treating Patients With Relapsed or Refractory Grade 1-3A Follicular Lymphoma
This phase Ib/II trial studies the side effects and best dose of toll-like receptor 9 (TLR9) agonist SD-101 when given together with ibrutinib and radiation therapy and to see how well they work in treating patients with Low…
- Conditions
- Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma, Grade 3a Follicular Lymphoma, Recurrent Follicular Lymphoma
- Trial name
- NCT02927964
- Testing
- Ibrutinib, Radiation Therapy, TLR9 Agonist SD-101
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Robert Lowsky
Breast Cancer
Locoregional Recurrence After Neoadjuvant Versus Adjuvant Chemotherapy
Neoadjuvant chemotherapy (NACT) for early-stage breast cancer is associated with an increased risk of locoregional recurrence (LRR).
- Trial name
- NCT06299930
- Testing
- Neoadjuvant chemotherapy, Adjuvant chemotherapy
- Where
- South Korea
- Volunteers
- 10,328 people
- Sponsor
- Seoul National University Hospital
Endometrial Cancer
GINECO-EN102b - BKM120 as Monotherapy in the Treatment of Initial or Recurrent Metastatic Endometrial Cancer
This study is to determine the clinical efficacy of BKM120 as monotherapy in the treatment of initial or recurrent metastatic endometrial cancer after first line radio chemotherapy.
- Trial name
- ENDOPIK (NCT01397877)
- Testing
- BKM120
- Where
- 45 sites in France
- Volunteers
- 24 people
- Sponsor
- ARCAGY/ GINECO GROUP
Chronic Pain, Recurrences
Comparison of Three Meshes in Lichtenstein Hernia Repair
Chronic pain may be a long-term problem after inguinal Lichtenstein hernioplasty. The aim of this study was to compare long-term results of hernioplasty using three different meshes (partly absorbable, lightweight polypropylene…
- Trial name
- Lichtenstein (NCT01295437)
- Testing
- Vypro II mesh, Premilene LP, Premilene mesh
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Kuopio University Hospital
Rectal Cancer
Efficacy and Safety Study of Neoadjuvant in Treating Patients With Resectable Local Recurrent Rectal Cancer
RATIONALE: Surgical resection and adjuvant therapy has become the main treatment for resectable local recurrent rectal cancer. However the efficacy and safety of adjuvant therapy is still unknown.
- Trial name
- NARC (NCT01271192)
- Testing
- surgical resection and adjuvant therapy, Neoadjuvant followed by operation
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Sun Yat-sen University
Cancer Patient
Effects of Regional Nerve Block on Cancer Recurrence
It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence.
- Trial name
- NCT03134430
- Testing
- Normal saline, peripheral Nerve block
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Luo Foquan
Non-Small-Cell Lung Carcinoma, Neoplasm Recurrence, Local
A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
This Phase II, multicenter, randomized trial is designed to make preliminary evaluations of the efficacy of combining bevacizumab with chemotherapy (docetaxel or pemetrexed) or Tarceva relative to chemotherapy (docetaxel or…
- Trial name
- NCT00095225
- Testing
- Avastin (bevacizumab), Tarceva (erlotinib HCl)
- Where
- 48 sites in United States
- Volunteers
- 122 people
- Sponsor
- Genentech, Inc.
Neoplasm Metastasis, Neoplastic Processes
Fractionated Radiosurgery for Painful Spinal Metastases
It is the study hypothesis that hypo-fractionated image-guided radiosurgery significantly improves pain relief compared to historic data of conventionally fractionated radiotherapy.
- Conditions
- Neoplasm Metastasis, Neoplastic Processes, Neoplasm Recurrence, Local, Neoplasm, Residual
- Trial name
- DOSIS (NCT01594892)
- Testing
- Radiosurgery
- Where
- 5 sites in Germany, Netherlands and 2 more
- Volunteers
- 60 people
- Sponsor
- Wuerzburg University Hospital
Recurrent Prostate Cancer
Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy APP21
The purpose of this study is to determine whether vaccination with the Ad/PSA vaccine will induce an anti-PSA immunity that will result in the destruction of the remaining prostate cancer cells.
- Trial name
- APP21 (NCT00583752)
- Testing
- Adenovirus/PSA Vaccine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- David M Lubaroff
Head and Neck Cancer
Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who Have Undergone Surgery for Advanced Hypopharyngeal Cancer, Oropharyngeal Cancer, Laryngeal Cancer, or Oral Cavity Cancer at High Risk of Recurrence
RATIONALE: Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01142414
- Testing
- panitumumab, cisplatin, fluorouracil
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Neoplasms, Neoplasm Recurrence, Local
Screening MRI for Cancer Recurrence in Patients Treated With Breast Conserving Therapy
A prospective, multicenter study: Primary objective: to assess the diagnostic yield of screening MRI compared to physical examination, mammography or ultrasonography in the detection of recurrence in patients treated with breast…
- Trial name
- NCT01257152
- Where
- South Korea
- Volunteers
- 754 people
- Sponsor
- Seoul National University Hospital
Malignant Tumors
125I Seed Brachytherapy Combined With Immunotherapy for Primary, Recurrent, or Metastatic Malignant Tumors
This prospective randomized trial evaluates the efficacy and safety of combining 125I seed interstitial brachytherapy with immune checkpoint inhibitor therapy in patients with primary, recurrent, or metastatic malignant tumors.
- Trial name
- NCT07277777
- Testing
- Immune Checkpoint Inhibitors, 125I Seed Implantation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Li Min
Cervical Cancer, Endometrial Cancer
CerviPrep for Applying Topical Gemcitabine to the Cervix in Treating Patients With Primary Endometrial, Cervical, or Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00610740
- Testing
- topical gemcitabine hydrochloride, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Recurrent Hepatocellular Carcinoma, Lenvatinib
The Comparison of TACE-Lenvatinib With TACE-Lenvatinib-ablation for Intermediate Recurrent Hepatocellular Carcinoma
Studies have shown that combination therapy of TACE with Lenvatinib could achieve better survival outcomes than TACE alone for hepatocellular carcinoma (HCC) at BCLC B stage.
- Conditions
- Recurrent Hepatocellular Carcinoma, Lenvatinib, Local Therapy, Ablation
- Trial name
- NCT06609850
- Testing
- TACE, Ablation, Lenvatinb
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Personalization of Breast Radiotherapy According to Loco-regional Recurrence Risk and Toxicity Probability
Our objective is based on a personalized approach of adjuvant breast radiotherapy by selecting patients according to tumor recurrence and toxicity risk.
- Trial name
- PROBA (NCT06382818)
- Testing
- COHORT A, COHORT B, COHORT C
- Where
- France
- Volunteers
- 854 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Carcinoma, Non-Small-Cell Lung, Stage IIIA Non-small Cell Lung Cancer
Safety and Efficacy of Vitamin C Infusion in Combination With Local mEHT to Treat Non Small Cell Lung Cancer
This trial studies efficacy and safety of combination of vitamin C infusion with modulated electro-hyperthermia (mEHT) in treatment of non small cell lung cancer patients.Phase I of this clinical study is to find the tolerable…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
- Trial name
- VCONSCLC (NCT02655913)
- Testing
- vitamin C, Modulated Electro-Hyperthermia (mEHT), Supportive care
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Clifford Hospital, Guangzhou, China
Rectal Neoplasms, Neoplasm Recurrence, Local
Incidence, Risk Factor, Treatment and Overall Survival of Locally Recurrent Rectal Cancer
Data on disease recurrence was collected for all primary rectal cancer patients diagnosed in the Netherlands over the first six months of 2015.
- Trial name
- NCT05475301
- Volunteers
- 1,431 people
- Sponsor
- Radboud University Medical Center
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of arsenic trioxide in treating children who have advanced…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00024258
- Testing
- arsenic trioxide
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Radiotherapy Side Effect, Locoregional Recurrence
RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
This is a prospective randomized Phase III trial to assess efficiency of two post mastectomy hypofractionation schedules (40 Gy /15 fx / 3 weeks, 5 days per week VS 28.5 Gy delivered in 5 once-weekly fractions of 5.7 Gy each…
- Trial name
- Breastcancer (NCT04550910)
- Testing
- Hypofractionation Schedules for Breast Cancer patients after mastecomy
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- National Cancer Institute, Egypt