Clinical trials: Long COVID
Neurocognitive Impairment, Mild
Statin TReatment for COVID-19 to Optimise NeuroloGical recovERy
STRONGER is an international, investigator initiated and conducted, pragmatic clinical trial to determine whether 40mg atorvastatin daily can improve neurocognitive function in adults with long COVID neurological symptoms.
- Trial name
- STRONGER (NCT04904536)
- Testing
- Atorvastatin, Standard Care
- Where
- Australia
- Volunteers
- 190 people
- Sponsor
- The George Institute
Post-COVID-19 Syndrome, Long COVID
Balance Acceptance and Commitment Therapy for Long COVID
This randomised controlled trial aims to investigate the efficacy of a psychological intervention for long COVID (LC) / post-COVID-19 syndrome (PCS) called Balance Acceptance and Commitment Therapy (Balance ACT).
- Trial name
- BalanceACT (NCT06231238)
- Testing
- Balance Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 196 people
- Sponsor
- King's College London
Long Covid
Improving Attention in Individuals With Long COVID-19
This study is to find out if the Attention Processing Training program is a potential treatment for brain fog symptoms, reported by people with Long-Covid. Also investigating the feasibility of completing this program virtually.
- Trial name
- LongCovAtten (NCT06503874)
- Testing
- Attention Training, Music Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Shirley Ryan AbilityLab
COVID-19, Long COVID
A Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a RO7496998 (AT-527) Study
This study will evaluate the long-term sequelae of COVID-19 in patients diagnosed with COVID-19 who previously enrolled in a RO7496998 (AT-527) study (i.e.
- Trial name
- MEADOWSPRING (NCT05059080)
- Where
- 35 sites in Argentina, Belgium and 8 more
- Volunteers
- 72 people
- Sponsor
- Hoffmann-La Roche
Long COVID, PASC Post Acute Sequelae of COVID 19
Valacyclovir Plus Celecoxib for Post-Acute Sequelae of SARS-CoV-2
To explore the safety and efficacy of daily doses of celecoxib + valacyclovir in the treatment of patients with prolonged symptoms caused by COVID-19.
- Trial name
- PASC (NCT06316843)
- Testing
- Valacyclovir celecoxib dose 1, Valacyclovir celecoxib dose 2
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Bateman Horne Center
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
Covid19, SARS (Disease)
Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19:
Recently, a new clinical presentation called "long covid" has been reported, for patients with symptoms lasting for more than 4 weeks from the onset of the disease.
- Trial name
- E-SPERANZA (NCT04695704)
- Testing
- Montelukast
- Where
- 8 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Chronic Fatigue Syndrome, Long COVID
Endothelial Dysfunction in Post-infection Fatigue Syndromes
Post-infection chronic fatigue syndromes, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID-19 condition (Long Covid), are conditions primarily characterized by debilitating fatigue.
- Trial name
- NCT06463106
- Where
- Austria
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
ME/CFS, Long COVID
Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?
Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people…
- Conditions
- ME/CFS, Long COVID, Post- COVID-19 Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- ME/CFS (NCT07454395)
- Testing
- Swimming, Cycling
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Long COVID
Rehabilitation and Return to Everyday Life for Patients With Long COVID
This non-randomised controlled trial will investigate if patients with long COVID receiving a structured and group-based rehabilitation intervention (The Long COVID Rehabilitation Intervention) will report a difference in mean…
- Trial name
- NCT06544382
- Testing
- The Long COVID Rehabilitation Intervention, Usual care
- Where
- Denmark
- Volunteers
- 914 people
- Sponsor
- Defactum, Central Denmark Region
Covid19, Post-COVID / Long-COVID
Post-coronavirus Disease-2019 Fatigue
Background: COVID-19 is consistently spreading throughout the world, and the number of recovered patients is steadily increasing.
- Trial name
- NCT04851561
- Testing
- Cardiopulmonary stress test (CPET)
- Where
- Israel
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Supplemental Nutrition Assistance Program Education, Post COVID Syndrome
Effect of a Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients.
This study aims to evaluate the impact of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical functionality in recovered COVID-19 patients.
- Conditions
- Supplemental Nutrition Assistance Program Education, Post COVID Syndrome, Endothelial Function
- Trial name
- NCT07544186
- Testing
- L-citrulline supplementation
- Where
- Mexico
- Volunteers
- 43 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Post-COVID ME/CFS
Repeat Immunoadsorption Post Covid ME/CFS
The evidence for an autoimmune etiology in postinfectious myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is growing.
- Trial name
- NCT05629988
- Testing
- IA with TheraSorb ® column
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Post-COVID Condition
Munich Long COVID Registry for Children, Adolescents, and Adults
The MLC-R aims to create a large-scale registry that provides data on epidemiology, phenotypes, and disease trajectories of and health care for Long COVID at any age in Germany, which can be used for future clinical trials.
- Trial name
- MLC-R (NCT05638724)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Long COVID
Study of Xiflam™ Treatment in Patients Post COVID-19 Infection Suffering From What is Known as Long COVID (LC)
The primary objective of this study is to evaluate the safety and efficacy of Xiflam versus Placebo in patients who present with signs and symptoms of Long COVID.
- Trial name
- NCT06437223
- Testing
- Tonabersat
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Inflammx Therapeutics Inc
Covid19
Managerial and Environmental Risk for COVID 19 in French Long Term Care Institutions
REMPAR EHPAD study addresses environmental and managerial factors associated with an outbreak of COVID 19 in French Long Term Care Institutions in the spring of 2020.
- Trial name
- REMPAR-EHPAD (NCT04579289)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Rennes University Hospital
Long COVID
Characterization of the Immunometabolic Signature in Long COVID-19.
The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC).
- Trial name
- LoCo-ImMet (NCT05758480)
- Testing
- Blood sample (at inclusion and 6 months later), Patient questionnaires (at inclusion and 6 months later)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Post-COVID-19 Syndrome
Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome
More than half of patients with post-COVID-19 syndrome experience fatigue. Rehabilitation is needed to treat this persistent symptom.
- Trial name
- COVIDATE-02 (NCT06814379)
- Testing
- Rehabilitation, Virtual reality based rehabilitation
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad de Granada
Anosmia, Asymptomatic COVID-19
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
The purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the SARS-CoV-2 virus (which causes COVID-19).
- Conditions
- Anosmia, Asymptomatic COVID-19, COVID-19 Respiratory Infection, Influenza
- Trial name
- NCT05040659
- Testing
- AROMHA Longitudinal Smell Test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital