Clinical trials: Long COVID Syndrome
Neuro-PASC, Long COVID
Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans
Mental health symptoms, including cognitive impairment ("brain fog"), following COVID-19 are of great concern to Veterans. This research seeks to advance understanding of the long-term effects of COVID-19 on neuropsychiatric and…
- Trial name
- PASC (NCT06932237)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Long Covid19
Non-pharmacological and TCM-based Treatment for Long COVID Symptoms
Cognitive impairment is one of the commonly reported Long COVID symptoms, mainly in terms of memory, attention, and executive function.
- Trial name
- NCT06042777
- Testing
- Acupuncture and TCM-based lifestyle management
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Long COVID, COVID-19
Group Psychotherapy in Long COVID
The aim of the present study was to establish a single-arm group psychotherapy and to evaluate its clinical effectiveness in long COVID patients.
- Trial name
- NCT06726772
- Testing
- Group Psychotherapy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
COVID-19, Pain, Chronic
Pain-related Long Covid in Covid-19 Survivors
The exploratory project aims to investigate the presence of pain as a long Covid-19 symptom in previously hospitalised patients and in non-hospitalised persons previously tested positive in a PCR test.
- Trial name
- NCT05520931
- Testing
- Questionnaire and register-based data assessment
- Where
- Denmark
- Volunteers
- 600,000 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Post-COVID-19 Syndrome, Post-COVID Syndrome
Post-COVID-19 Chronic Fatigue Syndrome
Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2.
- Trial name
- NCT05642923
- Testing
- Synthetic Vitamin B1
- Where
- Egypt
- Volunteers
- 528 people
- Sponsor
- ClinAmygate
Persistent COVID Condition
Predictors of Long-Term Evolution in Long COVID; 4-Year Follow-Up. (BioICOPER Follow-up Study)
Long COVID (persistent COVID) represents a major global health challenge due to its high prevalence (approximately 7%), significant impact on quality of life, and socioeconomic burden.
- Trial name
- NCT07295483
- Testing
- BioICOPER Long COVID Cohort
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Long COVID
Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID
The purpose of this study is to evaluate the effects of fermented foods on bacterial gut microbiome diversity of long-COVID subjects.
- Trial name
- NCT06560554
- Testing
- Fermented foods, Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Long COVID, Long Covid19
RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Trial name
- RECOVER-VITAL (NCT05595369)
- Testing
- Experimental: Paxlovid 25 day dosing, Experimental: Paxlovid 15 day dosing
- Where
- 69 sites in United States, Puerto Rico
- Volunteers
- 963 people
- Sponsor
- Kanecia Obie Zimmerman
Parosmia
Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia
Chronic olfactory dysfunction, both hyposmia and parosmia, from the COVID-19 pandemic is a growing public health crisis, affecting up to 1.2 million people in the United States.
- Trial name
- Stella (NCT06055270)
- Testing
- Stellate Ganglion Block
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post-COVID-19 Syndrome
Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome
This is a multicenter, randomized, placebo controlled, double-blind phase III trial with four parallel groups studying studying the feasibility of RCT in primary care as well as the effectiveness of treatment with prednisolone…
- Trial name
- PreVitaCOV (NCT05638633)
- Testing
- Prednisolone 20 mg/ 5 mg, Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12)
- Where
- 3 sites in Germany
- Volunteers
- 321 people
- Sponsor
- Wuerzburg University Hospital
Long Covid19, Long COVID
Intermittent Fasting and a No-Sugar Diet for Long COVID Symptoms
This cross-over study will assess a no added sugar diet, a restricted daily eating window, and one or two full day water fasts to determine if there is an effect on self-reported symptoms of Long Covid (PASC).
- Trial name
- NCT06214455
- Testing
- Low sugar diet and 10-12 hour eating window, Low sugar diet, 8 hour eating window and fasting
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Pacific Northwest University of Health Sciences
SARS-CoV-2 Infection, COVID-19
Index Individuals in SARS-CoV-2 Prevention Research Studies (COVID-19 Index Individuals Companion Study)
Clinical trials of prevention modalities for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease (COVID-19) and pneumonia are underway under separate protocol(s) for close contacts…
- Conditions
- SARS-CoV-2 Infection, COVID-19, Coronavirus Infection, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- IICov19PRS (NCT05074719)
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- University of Washington
Coronavirus COVID-19, Respiratory Infection
EEG as Predictor of HD-tDCS Effectiveness in Long COVID-19
COVID-19 is an infectious disease which presents a heterogenous clinical presentation. Recent investigations suggest that people who were infected by COVID-19 often develop physical disabilities (i.e.
- Trial name
- NCT05289128
- Testing
- Experimental group
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Paraíba
Long Covid
Effects of a Physical Rehabilitation Program on Long COVID
The objective of this clinical trial is to analyze the clinical, functional, and laboratory effects of a rehabilitation protocol designed for patients with long COVID; it may include any of the following: sex/gender, age groups…
- Trial name
- ReabCovid (NCT07651371)
- Testing
- Physical rehabilitation, Treadmill ergometer, Pulley
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Universidade do Estado do Pará
Long COVID
Fluvoxamine for Long COVID-19
This clinical trial aims to test the effects of fluvoxamine as a treatment for Long COVID. Fluvoxamine is an FDA approved SSRI for Obsessive Compulsive Disorder (OCD), that has already had success in preventing hospitalization in…
- Trial name
- NCT05874037
- Testing
- Fluvoxamine
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Washington University School of Medicine
COVID-19
Association of Phenotypic Age and Antibody Titers Among SARS-Co-V2 Infected Patients and Vaccinated Groups
Defining the antibody response to SARS-CoV-2 will be essential for understanding disease progression, long-term immunity, and vaccine efficacy.
- Trial name
- NCT05827939
- Testing
- Covid19 Vaccination dose
- Where
- Taiwan
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital