Clinical trials: Long-Haul COVID-19
SARS-CoV-2, Post-acute COVID-19 Syndrome
Neurological Outcome After SARS-CoV-2 Infection
Wider research context: Since the recognition of SARS-CoV-2 outbreak in 2019, there are now over 126 million COVID-19 cases worldwide with more than 2.7 million deaths.
- Trial name
- ATTRACT (NCT05025839)
- Testing
- No Intervention
- Where
- Austria
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Long COVID
Qigong for Post Acute Sequelae of COVID-19 Infection
The purpose of this study is to conduct a pilot feasibility study of a combination of external and internal qigong on health-related quality of life in individuals with prolonged symptoms following COVID-19 infection.
- Trial name
- NCT05675995
- Testing
- Qigong
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Davis
Long Covid
Improving Attention in Individuals With Long COVID-19
This study is to find out if the Attention Processing Training program is a potential treatment for brain fog symptoms, reported by people with Long-Covid. Also investigating the feasibility of completing this program virtually.
- Trial name
- LongCovAtten (NCT06503874)
- Testing
- Attention Training, Music Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Shirley Ryan AbilityLab
Long-Haul COVID-19
Effect of Plasmapheresis on Clinical Improvement and Biological Parameters of Patients With Long-haul COVID
Many patients infected with SARS-Cov-2 present in the months following infection with non-specific symptoms such as non-resolving fatigue, cognitive disorders, dyspnea, headaches, myalgias, sleep disorders, anosmia/ ageusia and…
- Trial name
- PLEXCOVIL (NCT05543590)
- Testing
- Plasmapheresis, Blood collection, Stool samples
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
Long Covid19
Chronic-disease Self-management Program in Patients Living With Long-COVID in Puerto Rico
This is a pilot non-randomized-controlled trial to evaluate the impact of "Tomando control de su salud", an evidenced-based intervention for chronic disease self-management in the quality of life of patients living with…
- Trial name
- NCT06208696
- Testing
- "Tomando control de su salud" (Spanish Chronic Disease Self-Management)
- Where
- Puerto Rico
- Volunteers
- 47 people
- Sponsor
- University of Puerto Rico
Long COVID, Post Acute Sequelae of COVID-19
Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID.
- Conditions
- Long COVID, Post Acute Sequelae of COVID-19, Post-Acute COVID-19
- Trial name
- PREVAIL-LC (NCT06161688)
- Testing
- Ensitrelvir
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Timothy Henrich
Systemic Inflammation, Neuroinflammation
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Background: COVID-19 can cause problems in different parts of the body. For most people, it causes fevers or trouble breathing. Some people might not recover all the way.
- Conditions
- Systemic Inflammation, Neuroinflammation, Microvascular Thrombosis
- Trial name
- NCT05350774
- Testing
- IV normal saline, IV immunoglobulin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
COVID-19
Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19
Fatigue is common and disabling in patients with post-COVID syndrome. There is no treatment available at this moment, and fatigue has important consequences.
- Trial name
- STIMULATECOVID (NCT05252481)
- Testing
- Active tDCS
- Where
- Spain
- Volunteers
- 47 people
- Sponsor
- Hospital San Carlos, Madrid
Long COVID
Prospective, Open-label Study of Seraph 100 in Patients With Prolonged COVID (PC)
This study will use a prospective, open, single-arm design, in which a group of 100 patients with a diagnosis of prolonged COVID, previously selected according to inclusion and exclusion criteria, and who have undergone informed…
- Trial name
- NCT06637800
- Testing
- Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100)
- Where
- Mexico
- Sponsor
- ExThera Medical Corporation
Long Covid
SingStrong: Strong Lungs Through Song - Long COVID-19 Study
Evidence is emerging that many individuals who recover from Covid-19 are experiencing a range of residual problems. These include fatigue, pain, reduced exercise tolerance and breathing issues.
- Trial name
- ss (NCT04810065)
- Testing
- SingStrong: Strong lungs through Song
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University of Limerick
Long COVID, Postural Orthostatic Tachycardia Syndrome
The Long COVID-19 Wearable Device Study
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can…
- Conditions
- Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis
- Trial name
- NCT05741112
- Testing
- Wearable device
- Where
- United States
- Volunteers
- 100,500 people
- Sponsor
- Scripps Translational Science Institute
COVID-19, Long COVID
Study of Vascular Endothelial Glycocalyx and Ophthalmic Injury, Prospective Cohort of Patients With Prolonged Post-COVID-19 Symptoms
The glycocalyx is a membrane coat composed of glycoproteins attached to the surface of cell membranes. Recent publications have drawn attention to the potential role of a degradation of the endothelial glycocalyx (a kind of gel…
- Trial name
- GLYCOVLONG (NCT05235698)
- Testing
- Ophthalmological examinations, GlycoCheck
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Long COVID-19 Syndrome
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19
This clinical trial aims to evaluate the safety and effectiveness of umbilical cord mesenchymal stem cell (UCMSC)-derived extracellular vesicle nebulization inhalation therapy for the treatment of chronic cough after COVID-19…
- Trial name
- NCT05808400
- Testing
- MSC-derived exosomes
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Huazhong University of Science and Technology
Post COVID-19 Syndrome
Randomized Double-Blind Phase 2 Study of Allogeneic HB-adMSCs for the Treatment of Chronic Post-COVID-19 Syndrome
This study will enroll up to 80 subjects with Chronic Post COVID-19 Syndrome. Subjects will receive four intravenous injections of either allogeneic HB-adMSC's or a placebo over 10 weeks with two follow-up visits and an end of…
- Trial name
- HBPCOVID02 (NCT05126563)
- Testing
- HB-adMSCs (allogeneic)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Hope Biosciences Research Foundation
Post COVID-19 Condition, Long COVID
Pycnogenol® in Post-COVID-19 Condition
To determine the effect of Pycnogenol® versus placebo on patient-reported health status in people with post COVID-19 condition.
- Trial name
- PYCNOVID (NCT05890534)
- Testing
- Pycnogenol®
- Where
- Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Long COVID, COVID-19
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID.
- Trial name
- CARE BEAR-LC (NCT05530317)
- Testing
- Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
Long COVID, Fatigue
Long COVID-19 Fatigue and Obstructive Sleep Apnea
Identify the relationship of obstructive sleep apnea (OSA) prevalence with post-COVID-19 fatigue that remains at least six months after acute disease
- Conditions
- Long COVID, Fatigue, Obstructive Sleep Apnea of Adult
- Trial name
- PostCoV2OSA (NCT05290350)
- Testing
- OSA
- Where
- 12 sites in Portugal
- Volunteers
- 300 people
- Sponsor
- Centro Hospitalar Universitario do Algarve
Long COVID
Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID
This will be a six-week, randomized, parallel, two group, open-label design. Patients will be treated with Paragon Novel Metabolic Regulator (PNMR) + standard of care (SOC) or SOC alone for 6 weeks for the treatment of Long…
- Trial name
- NCT07627815
- Testing
- Paragon Novel Metabolic Regulator (PNMR), Dietary and Lifestyle Recommendations
- Where
- 4 sites in Canada
- Volunteers
- 82 people
- Sponsor
- ParagonClinicals Inc.
Long Covid19
Effectiveness of Testofen Compared to Placebo on Long COVID Symptoms
This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Testofen (a specialised extract of Trigonella foenum-graecum (Fenugreek) seed) compared to placebo on post COVID-19 symptoms in otherwise…
- Trial name
- NCT05795816
- Testing
- Testofen, Microcrystalline cellulose
- Where
- Australia
- Volunteers
- 150 people
- Sponsor
- RDC Clinical Pty Ltd