Clinical trials: Long-Haul COVID-19
Long COVID
A Cross-sectional, Observational Study to Characterise Long COVID-19 in an Urban Sample of South African Adults
"Long-COVID'' (also known as post-COVID-19 syndrome, post-acute sequelae of COVID-19, or chronic COVID syndrome, used here as 'Long-COVID' for brevity), is a complex array of postconvalescence symptoms following SARS-CoV-2…
- Trial name
- ChaLOC (NCT05445713)
- Where
- 2 sites in South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Long COVID, Long COVID Syndrome
A Study to Examine Anktiva for the Treatment of COVID-19.
This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.
- Conditions
- Long COVID, Long COVID Syndrome, Long Covid 19
- Trial name
- NCT07123727
- Testing
- Anktiva
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
PASC Post Acute Sequelae of COVID-19
Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)
This study uses total-body [¹⁸F]F-AraG PET/CT imaging to investigate immune activation and vascular changes in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID.
- Trial name
- NCT07076862
- Testing
- A.1 - [¹⁸F]F-AraG PET/CT (90-min dynamic + 4-h static), A.2 - [¹⁸F]F-AraG PET/CT (60-min dynamic only), B.1 - [¹⁸F]F-AraG PET/CT (90-min dynamic + 4-h static)
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Robotic Exoskeleton, Post-acute Covid-19 Syndrome
Robotic Assisted Hand Rehabilitation Outcomes in Adults After COVID-19
Prolonged hospitalization in severe COVID-19 cases can lead to substantial muscle loss and functional deterioration. While rehabilitation is vital, conventional approaches encounter capacity constraints.
- Conditions
- Robotic Exoskeleton, Post-acute Covid-19 Syndrome, Rehabilitation Outcome, Physical And Rehabilitation Medicine
- Trial name
- NCT06137716
- Testing
- Training with a Robotic Hand Exoskeleton
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- University of Valladolid
COVID-19
A Study to Understand How the Use of Paxlovid Affected Healthcare Use in People With Pre-existing Conditions.
This is a cohort study that will include Paxlovid (nirmatrelvir-ritonavir) treatment eligible for people with a positive SARS-CoV-2 diagnostic test and at least one COVID-19 symptom.
- Trial name
- NCT07090486
- Testing
- nirmatrelvir-ritonavir
- Where
- United States
- Volunteers
- 14,000 people
- Sponsor
- Pfizer
Long Covid19, Autonomic Dysfunction
Autonomic Nervous System Affection Due to Post Covid Syndrome
Post-Covid syndrome is defined as symptoms that develop in addition to respiratory symptoms in individuals who have had Covid-19 infection for more than 12 weeks.
- Trial name
- NCT05502094
- Testing
- Heart Rate Variability Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Post-COVID-19 Syndrome
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
This clinical trial aims to learn about the therapeutic value of Methylprednisolone, a well-known immunosuppressant, on cognitive deficits in patients with post-COVID-19 syndrome (PCS).
- Trial name
- NCT05986422
- Testing
- Methylprednisolone
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19
Trial of Auricular Vagus Nerve Stimulation in Painful Covid Long
Patients infected with Covid 19 suffer from frequent pain (headache, migraines, joint pain, muscle pain) in the acute phase which may persist after a stay in intensive care or in an intensive care unit, in the event of…
- Trial name
- COLOSAT (NCT05205577)
- Testing
- Tens Eco Plus
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
Systemic Inflammation, Neuroinflammation
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Background: COVID-19 can cause problems in different parts of the body. For most people, it causes fevers or trouble breathing. Some people might not recover all the way.
- Conditions
- Systemic Inflammation, Neuroinflammation, Microvascular Thrombosis
- Trial name
- NCT05350774
- Testing
- IV normal saline, IV immunoglobulin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post-COVID-19 Syndrome
Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome
This is a multicenter, randomized, placebo controlled, double-blind phase III trial with four parallel groups studying studying the feasibility of RCT in primary care as well as the effectiveness of treatment with prednisolone…
- Trial name
- PreVitaCOV (NCT05638633)
- Testing
- Prednisolone 20 mg/ 5 mg, Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12)
- Where
- 3 sites in Germany
- Volunteers
- 321 people
- Sponsor
- Wuerzburg University Hospital
Long Covid
Antiviral Clinical Trial for Long Covid-19
The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid.
- Trial name
- NCT06511063
- Testing
- tenofovir disoproxil/emtricitabine, Selzentry
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Conscripts, Military Induction Board
Prevalence of ENT Diseseas
The aim of the present study will be to evaluate in conscripts at the military induction board the prevalence of rhinosinusitis, the prevalence of HPV vaccinations, the prevalence of hearing impairments and the prevalence of…
- Conditions
- Conscripts, Military Induction Board, ENT Disease, Rhinosinusitis Chronic
- Trial name
- PrENT (NCT06105346)
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
COVID-19
Disability Following Hospitalization in People of Working-age Surviving SARS-CoV-2 Infection - COVID-19
The purpose of the study is to describe disability following hospitalization in people of working-age surviving COVID-19.
- Trial name
- DisCOVID (NCT04724395)
- Testing
- Hospitalization
- Where
- France
- Volunteers
- 530 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-COVID-19 Syndrome
Transcutaneous Vagus Nerve Stimulation (tVNS) for Improved Recovery After Exertion.
Widespread infection with SARS-CoV-2 has resulted in millions of people having Post-COVID. Post-COVID is a complex, non-monolithic disease with diverse clinical manifestations.
- Trial name
- NCT06510985
- Testing
- transcutaneous vagus nerve stimulation, Monitoring, cardiowatch bracelet
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
COVID-19 Pandemic
Left Atrial Function of COVID-19-recovered Patients During the Surge of Omicron Variants
The goal of this observational study is to retrospectively analyze left atrial function in mild to moderate COVID-19-recovered patients.
- Trial name
- NCT06170307
- Testing
- two-dimensional speckle tracking echocardiography
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Haiyan Wang
COVID-19, Long COVID
Pulmonary Rehabilitation for Long COVID (Post COVID-19 Condition)
In the PuRe COVID study (a randomized, controlled, multicenter, pragmatic trial) the investigators aim to assess the effect of a pulmonary rehabilitation program in primary care on exercise capacity (6MWT) and daily life physical…
- Conditions
- COVID-19, Long COVID, Post COVID-19 Condition
- Trial name
- PuRe-COVID (NCT05244044)
- Testing
- Pulmonary rehabilitation in primary care
- Where
- 2 sites in Belgium
- Volunteers
- 76 people
- Sponsor
- University Hospital, Antwerp
Post-acute COVID-19 Syndrome, Long-COVID
Sociodemographic, Clinical, Quality of Life and Health Care Conditions in COVID-19 Survivors.
Sociodemographic, Clinical, Quality of Life, and Health Care Conditions After Hospital Discharge in Patients Who Required Admission to the Intensive Care Unit for COVID-19 at the Hospital Universitario Nacional Between April 2020…
- Conditions
- Post-acute COVID-19 Syndrome, Long-COVID, COVID-19, Long COVID
- Trial name
- NCT05185674
- Testing
- Exposure: Coronavirus disease 2019 (COVID-19)
- Where
- Colombia
- Volunteers
- 114 people
- Sponsor
- Javier Eslava
Post-COVID-19 Syndrome, Dyspnea
Home-Based Respiratory Muscle Strength Training Program for Individuals With Post-COVID-19 Persistent Dyspnea
To evaluate the extent to which a 12-week respiratory rehabilitation program consisting of inspiratory and expiratory breathing exercises compared to expiratory breathing exercises alone will help to improve shortness of breath…
- Trial name
- NCT06091280
- Testing
- Respiratory Muscle Strength Trainers
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of South Florida
Tinnitus, Subjective
Treatment for Post Acute COVID-19 Syndrome
Post-acute COVID-19 tinnitus has not been treated successfully. As tinnitus may be related to SARS-CoV-2 neurological manifestations.
- Trial name
- NCT05507372
- Testing
- Pimozide 1 MG
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Applied Biology, Inc.