Clinical trials: Long-Haul COVID-19
Post-Acute Sequelae of COVID-19
Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD)
Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury.
- Trial name
- NCT06330376
- Testing
- Usual care of traditional treatment, Specific DB program/Diaphragmatic manipulation program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Long COVID, Post Acute Sequelae of COVID-19
Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition
The RECLAIM study platform will be used to explore whether the use of Hyperbaric Oxygen therapy (HBOT) improves the symptoms of post covid cognitive dysfunction. Hyperbaric oxygen therapy is a well-established medical treatment.
- Conditions
- Long COVID, Post Acute Sequelae of COVID-19, Post-COVID-19 Condition
- Trial name
- RECLAIM-HBOT (NCT06452095)
- Testing
- Hyperbaric Oxygen therapy
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Covid19
Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise
This is a Phase 1b study to assess the safety and efficacy of COVI-MSC in treating post COVID-19 "long haulers" with pulmonary compromise.
- Trial name
- NCT04909892
- Testing
- COVI-MSC
- Sponsor
- Sorrento Therapeutics, Inc.
Long COVID, Dysautonomia
Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia
The current pilot study will recruit participants experiencing new, returning, or ongoing symptoms related to COVID-19 illness for at least four weeks after being first infected with SARS-CoV-2.
- Trial name
- NCT05566379
- Testing
- Mindfulness - Mindful Awareness Practices ( MAPs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
SARS-CoV-2 Infection, Post-acute Sequelae of SARS-CoV-2
The Canadian Respiratory Research Network Long COVID-19 Study
Preliminary studies suggest that COVID-19 causes long-term lung damage, even in young, otherwise healthy people who did not need to go to hospital or the ICU.
- Trial name
- NCT05181670
- Where
- 8 sites in Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Post Acute COVID-19 Syndrome, Long COVID
Safety, Tolerability and Efficacy of S-1226 in Post-COVID-19 Subjects With Persistent Respiratory Symptoms.
This is a randomized (1:1) , placebo-controlled phase II study to evaluate the safety, tolerability and efficacy of S-1226 in Post-COVID-19 subjects (n≤48) with persistent respiratory symptoms.
- Conditions
- Post Acute COVID-19 Syndrome, Long COVID, COVID-19 Respiratory Infection
- Trial name
- NCT04949386
- Testing
- S-1226 (8%)
- Volunteers
- 48 people
- Sponsor
- SolAeroMed Inc.
ME/CFS, Post-COVID ME/CFS
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS
The goal of this clinical trial is to learn about the effectiveness of repeated immunoadsorption intervention in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS).
- Trial name
- NCT05710770
- Testing
- Immunoadsorption
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Charite University, Berlin, Germany
Covid19
Hyperbaric Oxygen for Long COVID-19 Pulmonary Sequela
This is a pilot study in 24 subjects where half will be randomized to 10 treatments with hyperbaric oxygen (HBO). It will primarily study pulmonary sequelae with imaging and physiological measurements (low dose chest computer…
- Trial name
- NCT04905888
- Testing
- Hyperbaric oxygen therapy
- Where
- United States
- Sponsor
- Peter Lindholm
Long COVID, Post-Acute COVID-19
Post-Covid Condition Cohort: Evolution of Symptomatology, Patient Profile and Associated Prognostic Factors
The aim of our cohort is to collect prospectively, in a standardized and exhaustive manner, the health data of patients referred to the CAPCoV, our holistic referal post covid clinics for post-covid condition in order to be able…
- Conditions
- Long COVID, Post-Acute COVID-19, Post-Acute COVID19 Syndrome
- Trial name
- SYNPOCov (NCT05610436)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Central Hospital, Nancy, France
Long COVID
Cognitive Impairment and Return to Work in Long COVID
This retrospective, single-center observational study investigates the relationship between cognitive performance and return to work in patients with Long COVID.
- Trial name
- REWORK-COV (NCT07881029)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hopitaux de Saint-Maurice
COVID-19
Nutrition and LOComotoric Rehabilitation in Long COVID-19
Long COVID is a new phenomenon, in which individuals who experienced a SARS-CoV-2 infection still experience one or more symptoms, such as exercise intolerance, fatigue and/or muscle pains in addition to other COVID-related…
- Trial name
- UNLOCK (NCT05254301)
- Testing
- Intervention group
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- Universitair Ziekenhuis Brussel
Long COVID, Acute COVID-19
Chronic Stress as a Risk Factor for Long COVID
The disease caused by the pathogen SARS-CoV-2 is known as coronavirus disease with the acronym COVID-19. The acute phase of this condition typically lasts one to two weeks and usually results in a full recovery.
- Trial name
- StressLoC (NCT05652634)
- Where
- Austria
- Volunteers
- 380 people
- Sponsor
- Medical University of Graz
Post-COVID19 Condition
Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study
PAX is a prospective, randomized (1:1), double-blind, placebo-controlled study, that have as a objective to evaluate the safety and tolerability of plasma exchange (PE) in patients with Post Acute Covid-19 Syndrome (PCC)…
- Trial name
- NCT05445674
- Testing
- Plasma Exchange Procedure
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Post COVID-19 Condition, Long COVID Syndrome
Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)
The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of…
- Conditions
- Post COVID-19 Condition, Long COVID Syndrome, Persistent COVID-19, Persistent COVID Condition
- Trial name
- THALASSA (NCT06766825)
- Testing
- Plitidepsin 1.5 mg/day
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
SARS-CoV2 Infection
Fatigue a Long COVID-19 Symptom Substudy of FSC19-KN Trial
Prospective, controlled follow-up observation of SARS-CoV-2 positive patients with regard to the aspect of fatigue (cognitive / motor) and psychological disorders in the areas of anxiety, depression and somatization.
- Trial name
- SubFSC19-KN (NCT04883190)
- Testing
- Fulfilling Questionaires
- Where
- Germany
- Volunteers
- 353 people
- Sponsor
- Hegau-Bodensee-Klinikum Singen
Long Covid19, Long COVID
Intermittent Fasting and a No-Sugar Diet for Long COVID Symptoms
This cross-over study will assess a no added sugar diet, a restricted daily eating window, and one or two full day water fasts to determine if there is an effect on self-reported symptoms of Long Covid (PASC).
- Trial name
- NCT06214455
- Testing
- Low sugar diet and 10-12 hour eating window, Low sugar diet, 8 hour eating window and fasting
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Pacific Northwest University of Health Sciences
Post-COVID-19 Syndrome
Physical Activity Coaching in Patients with Post-COVID-19
This randomized clinical trial aims to compare the effects of a 12-week behavioral physical activity intervention (i.e., physical activity coaching) with usual care (i.e., World Health Organization recommendations for being…
- Trial name
- NCT06165978
- Testing
- Self-monitoring, Goal setting and review, Education
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- University of Alcala
Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS
Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection.
- Conditions
- Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), SARS CoV 2 Infection, Long COVID19
- Trial name
- NCT07189936
- Testing
- To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To Measure Splanchnic venous capacitance after 28 days of Treatment with 2HOBA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
COVID-19, Tuberculosis
Tuberculosis as a Risk Factor for a Worse Outcome Post-Sars-CoV-2 Infection
This study has two main objectives. First, the clinical characteristics and outcomes of hospitalized patients with symptomatic Covid-19 disease will be compared between persons with a history of past or current TB infection or…
- Conditions
- COVID-19, Tuberculosis, Post-acute COVID-19 Syndrome
- Trial name
- Co-TB (NCT05643781)
- Where
- South Africa
- Volunteers
- 157 people
- Sponsor
- The Aurum Institute NPC
Long COVID
Neurobiological Underpinnings of Neuropsychological Consequences in Long COVID
Objectives: To describe the standardized evaluation of the psychological and cognitive function of long COVID patients and their evolution, to compare immunological and HPA-axis related biomarkers between long COVID patients and…
- Trial name
- Cov-N-Psy (NCT06279936)
- Testing
- Neuropsychological battery, Surveys and symptom severity questionnaires, Blood withdrawal
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen