Clinical trials: Long-term Postoperative Complications
Elderly, Hip Fracture Surgery
Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery
Delirium is common in the elderly after hip fracture surgery, and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after hip fracture surgery, dexmedetomidine supplemented analgesia can…
- Conditions
- Elderly, Hip Fracture Surgery, Patient-controlled Analgesia, Dexmedetomidine
- Trial name
- NCT04955249
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Peking University First Hospital
Hydronephrosis
Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis
The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for…
- Trial name
- NCT01839006
- Testing
- dismembered pyeloplasty
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Dysplasia; Hip, Prosthesis Survival
Long-term Outcomes of Conical Tapered Stems in Cementless Total Hip Arthroplasty Due to Congenital Hip Pathologies
A retrospective consecutive population of patients treated with conical tapered stems in cementless total hip arthroplasty for osteoarthritis due to congenital hip pathologies will be selected.
- Trial name
- RetroCone (NCT04748458)
- Testing
- Conical tapered stem
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Istituto Ortopedico Rizzoli
Short Bowel Syndrome
Survival and PN Dependence in SBS Patients
Short bowel syndrome (SBS) is a rare condition resulting from the loss of portions of the small intestine, and can cause a spectrum of metabolic and physiologic disturbances.The objective of this study was to determine the…
- Trial name
- NCT06102668
- Volunteers
- 173 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Chronic Intestinal Insufficiency, Advanced Glycation and Products
AGE Accumulation in Patients on Long-term Parenteral Nutrition
This prospective and observational study aims to evaluate the accumulation of advanced glycation end-products (AGEs) in adult and pediatric patients starting long-term parenteral nutrition, by non-invasive skin AGE measurements…
- Conditions
- Chronic Intestinal Insufficiency, Advanced Glycation and Products, Parenteral Nutrition
- Trial name
- NUPARAGE2 (NCT07392801)
- Testing
- Non-invasive skin AGE measurements
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Short Bowel Syndrome, Anticoagulation
Pharmacokinetics of Apixaban in Patients With Short Bowel Syndrome Requiring Long Term Parenteral Nutrition
Short bowel syndrome (SBS) is defined as a loss of function of the small intestine resulting in a malabsorptive disorder. In SBS, oral drug absorption may be altered due to extensive intestinal resection.
- Trial name
- ABSORB (NCT04344717)
- Testing
- Apixaban single dose, Apixaban steady-state
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Wounds and Injuries, Wound Infection
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries
- Trial name
- FTFDT2 (NCT03880188)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Survival, Prosthesis, Prosthesis Durability
SPAnish Aortic VALVE Multicentric Study
Currently there is an increase in the use of bioprosthesis worldwide (> 70% according to national data of the Spanish Society of Thoracic and Cardiovascular Surgery).
- Conditions
- Survival, Prosthesis, Prosthesis Durability, Valve Heart Disease
- Trial name
- SPAVALVE (NCT03595423)
- Testing
- Surgical AVR with bioprosthetic or mechanical prosthesis
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cancer Surgery, Intraoperative Hypothermia
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor.
- Conditions
- Cancer Surgery, Intraoperative Hypothermia, Targeted Temperature Management, Postoperative Delirium
- Trial name
- NCT06256354
- Testing
- Routine thermal management, Target temperature management
- Where
- 36 sites in China
- Volunteers
- 3,992 people
- Sponsor
- Peking University First Hospital
Pain, Postoperative, Neural Therapy of Huneke
Evaluation of the Neural Therapy Effect on Long Term Postoperative Discomforts in Patients Who Undergo Bilateral Tubal Ligation
The aim of this study was to explore the effect of neural therapy on postoperative pain and discomfort such as abdominal swelling; and gynecologic symptoms such as dysmenorrhea, dyspareunia, amount of menstrual bleeding and…
- Conditions
- Pain, Postoperative, Neural Therapy of Huneke, Dysmenorrhea, Dyspareunia
- Trial name
- NCT03761862
- Testing
- Neural Therapy
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Short Bowel Syndrome (SBS)
Efficacy and Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome
The purpose of this study is to understand the safety and efficacy of twice weekly glepaglutide 10 mg in adult patients with short bowel syndrome (SBS), who were previously enrolled in the EASE SBS 2 or EASE SBS 3 trials.
- Trial name
- EASE SBS 6 (NCT07228403)
- Testing
- Glepaglutide 10 mg
- Where
- 16 sites in United States, Belgium and 5 more
- Volunteers
- 28 people
- Sponsor
- Zealand Pharma
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071988
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children
Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment.
- Conditions
- Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children, Perioperative/Postoperative Complications, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00258453
- Testing
- metabolic assessment, physiologic testing, biopsy
- Where
- 109 sites in Austria, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
Intestinal Insufficiency, Short Bowel Syndrome
Prescription Pattern of Adjuvant Drugs and Vitamins in Patients Undergoing Long-term Home Nutritional Support for Intestinal Insufficiency
Intestinal insufficiency due to short bowel syndrome is a chronic, disabling condition with significant morbidity and mortality.Standard care includes home parenteral/enteral nutrition as well as intestinal transplantation…
- Trial name
- NCT01696656
- Testing
- Drug prescription pattern
- Where
- Brazil
- Volunteers
- 37 people
- Sponsor
- University of Sao Paulo
Stress Urinary Incontinence, Postsurgical Pain
The Follow-up After Shorter Tapes Study. Effectiveness and Safety of Shorter Trans-obturator Tapes.
Urinary incontinence after pregnancy and labor affects 1 in 3 women and has a negative impact on quality of life (QOL), limiting women's physical activity and impairing sexual function.
- Conditions
- Stress Urinary Incontinence, Postsurgical Pain, Follow-Up Studies
- Trial name
- FAST (NCT06731985)
- Where
- Norway
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy
Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC
Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes.
- Conditions
- Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Hydration, Diuresis
- Trial name
- NCT05939193
- Testing
- Urine-guided hydration, Routine hydration, Forced administration of furosemide
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Peking University First Hospital
Postoperative Pain
NALDEBAIN for Postoperative Pain Management in Take Down of Anastomosis
NALDEBAIN ER injection, invented by Taiwanese, launched in 2017, is a nalbuphine synthetic prodrug with oil-based solution to extend the release in human body by intramuscular injection.
- Trial name
- NCT03854851
- Testing
- Naldebain, Morpine
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Pain, Postoperative
Short and Long-term Effects of Surgical Repair of Pectus Deformities
A large number of institutions have reported their early results with minimally invasive repair of pectus excavatum and open repair of pectus carinatum, but only few have addressed the outcomes relevant to the concerns of the…
- Trial name
- NCT01329120
- Testing
- Minimally invasive repair of pectus excavatum, Open surgical repair of pectus carinatum
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- University of Aarhus
Older Patients, Surgery
Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes.
- Conditions
- Older Patients, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07576543
- Testing
- Dex-Esk, Active tDCS
- Where
- 6 sites in China
- Volunteers
- 1,996 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Kidney Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Warm Ischemia or Cold Ischemia During Surgery in Treating Patients With Stage I Kidney Cancer
RATIONALE: Warm ischemia is the clamping of blood vessels without cooling the kidney. Cold ischemia is the clamping of blood vessels with kidney cooling.
- Conditions
- Kidney Cancer, Long-term Effects Secondary to Cancer Therapy in Adults, Perioperative/Postoperative Complications, Urinary Complications
- Trial name
- NCT00743236
- Testing
- cold ischemia procedure, warm ischemia procedure
- Where
- 8 sites in United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences