Clinical trials: Longitudinal Studies
Complications Wounds, Negative Pressure Wound Therapy
Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial
Incisional negative pressure therapy (INPWT) has previously been shown in certain patient populations to decrease wound healing complications, decrease the rate of hematomas and seromas, as well as have better scar quality.
- Conditions
- Complications Wounds, Negative Pressure Wound Therapy, Wound Healing Delayed, Incisional
- Trial name
- NCT03010137
- Testing
- Incisional Negative Pressure Wound Therapy, Standard Closure with Skin Glue, PICO (Smith&Nephew)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Lip Augmentation
A Study to Evaluate the Effectiveness of Juvéderm® VOLIFT™ With Lidocaine for Lip Augmentation
This is an open-label, multi-center, study where eligible participants will undergo treatment with Juvéderm® VOLIFT™ with Lidocaine injected into the lips for lip augmentation.
- Trial name
- LIPS (NCT03796728)
- Testing
- Juvéderm® VOLIFT™ with Lidocaine
- Where
- 4 sites in Portugal, United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Allergan
Colorectal Cancer Screening
Colon Capsule Endoscopy (CCE) Versus Computed Tomographic Colonography (CTC) in the Identification of Colonic Polyps in a Screening Population.
The primary objective of this multicenter, prospective, randomized study is to assess the diagnostic yield of Colon Capsule Endoscopy (CCE) versus Computed Tomographic Colonography (CTC) in a screening population.
- Trial name
- TOPAZ (NCT02754661)
- Testing
- COLON Capsule endoscopy, Computed Tomographic Colonography
- Where
- 13 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Cataract
Evaluate the Safety and Effectiveness of the enVista® One-Piece Hydrophobic Acrylic Trifocal Intraocular Lens
The objective of the study is to evaluate the safety and effectiveness of the enVista trifocal intraocular lens when implanted in the capsular bag.
- Trial name
- NCT03603600
- Testing
- enVista MX60E, enVista MX60EF
- Where
- 23 sites in United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Respiratory Syncytial Virus
A Prospective, Epidemiological Study to Assess the Disease Burden of Respiratory Syncytial Virus Associated, Suspected Lower Respiratory Tract Infections in Newborns, From 0 to 2 Years of Age and Risk of Development of Wheeze and Asthma From 0 to 6 Years of Age
The purpose of this study is to assess the incidence and associated healthcare utilization of RSV-associated, suspected LRTI in a general population of infants from birth up to 2 years of age, and also to assess the accuracy of a…
- Trial name
- NCT01995175
- Testing
- Nasal swab sampling, Blood sampling, Diary cards
- Where
- 23 sites in United States, Argentina and 6 more
- Volunteers
- 2,409 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cataract
Accuracy of the New Barrett TAL Formula With the Argos Measurements: A Multicenter Prospective Study
This study is a prospective, multi-site, multi-surgeon, observational study of refractive accuracy with the Argos using BTAL after successful cataract surgery.
- Trial name
- NCT06085131
- Testing
- Argos
- Where
- 6 sites in United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- Shammas Eye Medical Center
Acute Musculoskeletal Disease, Sprains
Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
This study evaluates the addition of a lidocaine patch to ibuprofen in the treatment of acute musculoskeletal pains. Half of the participants will get only ibuprofen for their pain, while other half will receive lidocaine patch…
- Conditions
- Acute Musculoskeletal Disease, Sprains, Sprains and Strains, Injuries
- Trial name
- NCT03571737
- Testing
- Ibuprofen, Lidocaine Patch 4%
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Disorder of Soft Tissue
Safety Evaluation of Aline HA, an Implanted Cross-Linked HA Device
The protocol hypothesis is that treatment with Aline HA™ will be safe through 6 months as determined by clinical assessment of treatment sites and routine tracking of adverse events.
- Trial name
- NCT01708213
- Testing
- Aline HA
- Where
- 2 sites in Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TauTona Group
Presbyopia
A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near Vision in Presbyopic Patients
This study will be a prospective, multicenter clinical trial in which a total of 400 subjects will be enrolled. All subjects will be followed over a 36 month time frame with a maximum of 15 clinical sites participating.
- Trial name
- NCT01373580
- Testing
- The Raindrop Near Vision Inlay
- Where
- 11 sites in United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- ReVision Optics, Inc.
Colorectal Polyp, Colorectal Adenoma
Standard Colonoscopy Versus Colonoscopy With Endocuff Vision
This study seeks to compare colonoscopy results between a standard method and one using a distal scope attachment (Endocuff Vision).
- Conditions
- Colorectal Polyp, Colorectal Adenoma, Colon Cancer
- Trial name
- NCT03361917
- Testing
- Endocuff Vision
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
HIV Infections
The Raltegravir and Ribavirin Pharmacokinetics (PK) Study
The purpose of this study is to look at levels of both a new anti-HIV drug called raltegravir and an existing anti-hepatitis C drug called ribavirin to see if they affect the blood levels of each other when given separately and…
- Trial name
- NCT00982553
- Testing
- Ribavirin, Raltegravir
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cognitive Decline
Cognitive Function in Elderly Marathon Runners
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly.
- Trial name
- APSOEM (NCT01045031)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Colon Mucous, Colonoscopy
Dose the Saline Reduce the Mucus Production When Water Exchange Colonoscopy is Used?
This is a study to compare the left colon mucus production between carbon dioxide (CO2) insufflation and water exchange (WE) colonoscopy in patients that require a routine or repeat colonoscopy.
- Trial name
- NCT04769739
- Testing
- CO2, Water, 50% saline
- Where
- Taiwan
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Reduction of Unwanted Fat
Non-Invasive Cooling of Fat Cells
The purpose of this study is to evaluate a non-invasive cooling device to determine if cold exposure will consistently result in a reduction of subcutaneous fat.
- Trial name
- NCT00762437
- Testing
- Zeltiq Dermal Cooling Device
- Where
- 11 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Gastric Bypass, Parathyroid Hormone
Trial Of Paricalcitol and Cholecalciferol(Vitamin D3) in the Treatment Of Secondary Hyperparathyroidism in Patients After ROUX-EN-Y Gastric Bypass Surgery
Evaluate the efficacy of paricalcitol, cholecalciferol, and placebo in the reduction of parathyroid hormone in patients after Roux-en-Y gastric bypass surgery (RYGB).
- Trial name
- ExtenD (NCT01138475)
- Testing
- Paricalcitol, Cholecalciferol
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Kerstyn C. Zalesin, M.D.
Lichen Planopilaris, Frontal Fibrosing Alopecia
Oral Low-Dose Naltrexone for Lichen Planopilaris and Frontal Fibrosing Alopecia
Oral naltrexone was initially FDA approved to treat opioid use disorder and alcohol dependence at doses from 50-100mg/day. At lower doses of 1-5mg/day, naltrexone has been used off-label with success in treatment of several…
- Trial name
- NCT04409041
- Testing
- Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes
Prospective Study of the Impact of Insulin Pump Therapy in Young Children With Type 1 Diabetes
The purpose of the study is to examine glycemic and neuropsychological outcomes in very young children with Type I diabetes who are being started on insulin pumps and to compare their outcomes to children who are not utilizing…
- Trial name
- NCT00727220
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Indiana University
Preterm Delivery
Neonatal Outcome by Reason for Delivery
To determine the rate of Composite Neonatal Morbidity for very preterm babies delivered secondary to preterm labor (PTL) vs. prelabor rupture of membranes (PROM).
- Trial name
- NCT01818518
- Where
- 10 sites in United States
- Volunteers
- 995 people, healthy volunteers welcome
- Sponsor
- Obstetrix Medical Group
Diabetes, Type I
Efficacy & Safety of Inhaled Insulin in Type 1 Diabetes
To determine the safety and efficacy of inhaled insulin in the treatment of type 1 diabetes
- Trial name
- NCT00308308
- Testing
- Technosphere Insulin, Active comparator
- Where
- 129 sites in United States, Argentina and 8 more
- Volunteers
- 589 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation