Clinical trials: Loss of Consciousness
Type 1 Diabetes, Hypoglycemia Unawareness
A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes
This is a single center, double blind randomized cross over design trial that will compare the impact of N-acetyl cysteine (200 mg) vs.
- Trial name
- NAC for HAAF (NCT02206152)
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
Sick Sinus Syndrome, Complete Heart Block
Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
The number of cardiac implantable electronic devices (CIEDs) implanted each year has grown rapidly over the past two decades. CIED infections, defined as infections involving the generator implant site (pocket) and/or…
- Conditions
- Sick Sinus Syndrome, Complete Heart Block, Syncope, Chronic Systolic Heart Failure
- Trial name
- ENVELOPE (NCT02809131)
- Testing
- polymixin/bacitracin, cephalexin, or levofloxacin, or clindamycin, Saline
- Where
- United States
- Volunteers
- 1,010 people
- Sponsor
- Vanderbilt University Medical Center
Vasovagal Syncope
Syncope Prediction Study
The purpose of this study is to perform a prospective evaluation of the vasovagal syncope prediction algorithm, called Tilt Test Analyzer, during head up tilt testing tests in one center in the United Kingdom.
- Trial name
- SPS (NCT02140567)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Medtronic BRC
Hypoglycemia Unawareness
Carvedilol in Treating Hypoglycemia Unawareness
Type 1 diabetes mellitus (T1DM) can lead to cardiovascular, renal and neurological complications if left poorly-controlled over prolonged periods of time.
- Trial name
- NCT03538015
- Testing
- Carvedilol 3.125 mg, Carvedilol 2.5 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Owen Chan, PhD
Hypoglycemia Unawareness, Diabetes Mellitus, Type 1
Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses
This is a prospective, randomized, controlled, double-blind, parallel 4-group trial with the primary analysis after 4 weeks of treatment with continuous subcutaneous glucagon infusion (CSGI) or placebo.
- Trial name
- NCT03490942
- Testing
- Glucagon
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- Xeris Pharmaceuticals
Type 1 Diabetes, Hypoglycemia Unawareness
Naltrexone and Hypoglycemia in Type 1 Diabetes
Low blood sugar is also called hypoglycemia. Usually, it is mild and can be treated quickly and easily by eating or drinking a small amount of a sugar-rich food.
- Trial name
- Naltrexone (NCT01053078)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Syncope
ISSUE3: International Study on Syncope of Uncertain Etiology 3
ISSUE 3 is a multi-center, prospective, randomised controlled double-blind study aimed to assess the effectiveness of pacemaker therapy for prevention of asystolic neurally-mediated syncope.
- Trial name
- NCT00359203
- Testing
- Dual chamber pacemeker
- Where
- Italy
- Volunteers
- 511 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Brain Death, Heart Failure
Intravenous Thyroxine for Heart-Eligible Organ Donors
This randomized controlled trial will evaluate whether intravenous thyroxine infusion given to brain-dead organ donors who are eligible to donate hearts for 12 hours will result in more hearts transplanted than saline placebo
- Trial name
- NCT04415658
- Testing
- Thyroxine, Saline
- Where
- 14 sites in United States
- Volunteers
- 838 people
- Sponsor
- Washington University School of Medicine
Symptomatic Neurogenic Orthostatic Hypotension
Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, multi-center, open-label study to evaluate the safety and tolerability of ampreloxetine in subjects with primary autonomic failures (MSA, PD, and PAF) and symptomatic nOH over 182 weeks.
- Trial name
- OAK (NCT04095793)
- Testing
- ampreloxetine
- Where
- 55 sites in United States, Australia and 16 more
- Volunteers
- 110 people
- Sponsor
- Theravance Biopharma
Syncope
Syncope Decision Aid for Emergency Care
Syncope, or transient loss of consciousness/fainting, is a common emergency department (ED) complaint responsible for over 1 million ED visits yearly.
- Trial name
- SynDA (NCT02971163)
- Testing
- SynDA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type1diabetes, Hypoglycemia
Adrenergic System in Islet Transplantation
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation.
- Conditions
- Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness, Islet Cell Transplantation
- Trial name
- NCT03079921
- Testing
- Phentolamine, Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Malaria, Cerebral
Treating Brain Swelling in Pediatric Cerebral Malaria
This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as…
- Trial name
- TBS (NCT03300648)
- Testing
- Mechanical ventilation, Hypertonic saline
- Where
- Malawi
- Volunteers
- 57 people
- Sponsor
- Michigan State University
Type 1 Diabetes Mellitus With Hypoglycemia
A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness
VC02-101 will evaluate an experimental cell replacement therapy intended to provide a functional cure to subjects with Type 1 Diabetes and Hypoglycemia Unawareness.
- Trial name
- NCT03163511
- Testing
- VC-02 Combination Product
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 49 people
- Sponsor
- ViaCyte
Traumatic Brain Injury
Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness
The purpose of this study is to examine the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with Amantadine relative to rTMS Alone and Amantadine Alone for persons in chronic states of…
- Trial name
- NCT02025439
- Testing
- rTMS, Amantadine
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Edward Hines Jr. VA Hospital
Lennox-Gastaut Syndrome
Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrome
The objective of this study is to evaluate the long-term safety and effectiveness of open-label clobazam in the treatment of drop seizures in subjects with LGS.
- Trial name
- LGS (NCT01160770)
- Testing
- Clobazam
- Volunteers
- 267 people
- Sponsor
- Lundbeck LLC
Symptomatic Neurogenic Orthostatic Hypotension, MSA
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, MSA, Parkinson's Disease (PD), Pure Autonomic Failure (PAF)
- Trial name
- REDWOOD (NCT03829657)
- Testing
- ampreloxetine
- Where
- 82 sites in United States, Australia and 17 more
- Volunteers
- 203 people
- Sponsor
- Theravance Biopharma
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Brief Loss of Consciousness
Applicability of Syncope Guidelines in Cataluña
The aim of SYNCAT study is to study the level of adherence of the centers in Cataluña tu the Syncope Guidelines ESC2009 for the diagnosis and treatment of syncope and the impact that following them can have in the prognosis of…
- Trial name
- SYNCAT (NCT01721369)
- Testing
- Transient Loss of Consciousness (T-LOC)
- Volunteers
- 581 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Hypoglycemia Unawareness
Assessment of the Impact of Real-Time Continuous Glucose Monitoring on People Presenting With Severe Hypoglycaemia
This study aims to assess the impact of real-time continuous glucose monitoring on the frequency, duration, awareness and severity of hypoglycaemia in people with type 1 diabetes and a recent history of severe hypoglycaemia…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia Unawareness, Hypoglycemia
- Trial name
- AIR-CGM (NCT03748433)
- Testing
- Dexcom G6 CGM, Tandem t:slim X2 Insulin Pump
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London