Clinical trials: Low Anterior Resection Syndrome
Low Anterior Resection Syndrome
Transanal Irrigation for Low Anterior Resection Syndrome.
The aim of this study is to investigate whether the high-volume transanal irrigation (TAI) performed by the Peristeen Plus® system is superior to the low-volume TAI performed by standard 250ml water enema for the treatment of Low…
- Trial name
- HiLoV_TAI (NCT05245331)
- Testing
- Peristeen® Transanal irrigation system with the conic catheter, Standard reusable enema
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
Rectal Cancer
Effects of Dried Plum (Prune) Intake on the Incidence of Low Anterior Resection Syndrome in Patients With Rectal Cancer
Colorectal cancer is the third leading cause of cancer death and the fourth most commonly diagnosed cancer in the world. The importance of improving the quality of life of patients after colorectal cancer surgery has been…
- Trial name
- NCT05907642
- Testing
- Prune (dried plum)
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Low Anterior Resection Syndrome, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation in the Treatment of Major LARS
Randomized trial to assess FMT efficacy in improving bowel function for major LARS patients. 40 subjects, blinded, randomized to FMT or probiotics.
- Trial name
- FMT-LARS (NCT06475430)
- Testing
- fecal microbiota transplantation, Formulated probiotic supplements
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Colorectal Surgery
Efficiency of Neurostimulation of Tibial Nerve in the Treatment of Low Anterior Resection Syndrome
The aim of this study is to evaluate the efficiency of the Neuroestimulation of the Posterior Tibial Nerve for the treatment of this syndrome.
- Trial name
- NCT02517853
- Testing
- Posterior tibial nerve stimulation
- Where
- 2 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Patient Empowerment, Low Anterior Resection Syndrome
Interactive Online Informational and Peer Support App for Patients with Low Anterior Resection Syndrome
After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more.
- Conditions
- Patient Empowerment, Low Anterior Resection Syndrome, Colo-rectal Cancer, Peer Group
- Trial name
- NCT04469426
- Testing
- Interactive online informational and peer support app
- Where
- 5 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Low Anterior Resection Syndrome
Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery
A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel…
- Trial name
- NCT03215017
- Testing
- Transanal irrigation, Medication
- Where
- 3 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Mirna Abraham-Nordling
Rectal Cancer, Low Anterior Resection Syndrome
Rectal Cancer Survivorship: Impact of Low Anterior Resection Syndrome (LARS) on the Quality of Life
Quality of life and risk factors for developing major LARS are explored. Therapeutic options were explored in the cohort experiencing major LARS
- Trial name
- NCT06059170
- Testing
- LARS score/ EORTC QLQ C30
- Where
- Belgium
- Volunteers
- 187 people
- Sponsor
- University Hospital, Ghent
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Colorectal Cancer
Incidence and Risk Factors of Low Anterior Resection Syndrome
Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome.
- Trial name
- NCT06359730
- Testing
- LARS score questionnaire
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Low Anterior Resection Syndrome
The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure
This study was a single-center RCT study to compare the effect of preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon with that of traditional…
- Trial name
- NCT06569966
- Testing
- preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon
- Where
- China
- Volunteers
- 154 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Low Anterior Resection Syndrome
Transanal Irrigation - Best Treatment Possibility for Low Anterior Resection Syndrome? Multicenter, Randomized Clinical Trial
Introduction: About 50% of patients who undergo rectal resection (mostly as a treatment for rectal cancer) suffer from various and partly severe functional problems, despite the preservation of the anal fold.
- Trial name
- NCT05920681
- Testing
- Transanal irrigation, Best supportive care
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Low Anterior Resection Syndrome, Rectal Cancer
Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.
The goal of this clinical trial is to learn if antegrade intestinal fluid reinfusion works to prevent low anterior resection syndrome (LARS) in patients with prophylactic ileal stoma. The main questions it aims to answer are: 1.
- Trial name
- NCT07537998
- Testing
- intestinal fluid infusion, potable water
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Pei-Rong Ding
Rectal Cancer, Low Anterior Resection Syndrome
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
The study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative…
- Trial name
- NCT02177084
- Testing
- PTNS
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prevention, LARS - Low Anterior Resection Syndrome
Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)
The main aim of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LAR syndrome in patients after mini-invasive rectal resection.
- Conditions
- Prevention, LARS - Low Anterior Resection Syndrome, Pelvic Floor Disorders, Rectal Cancer
- Trial name
- CH1 (NCT06519006)
- Testing
- Pelvic floor exercise
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- F. D. Roosevelt University Hospital
Low Anterior Resection Syndrome, Rectal Cancer
Evaluation of a Decision Aid Tool in Rectal Cancer patiënts
Adapt and evaluate a decision aid for patients with rectal cancer. Phase 1 : decision aid testing (Delphi) multicentric Phase 2: pilot test decision aid
- Trial name
- NCT04938336
- Testing
- Delphi Procedure and interviews
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Rectal Cancer, Low Anterior Resection Syndrome
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome
The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients.
- Trial name
- TEDRMARS (NCT04023448)
- Testing
- transverse coloplasty pouch
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University