Clinical trials: Low Cardiovascular Risk
Body Weight, Obesity
Meta Analysis of the Effect of a Low Glycemic Index Diet and Glycemic Load on Body Weight
A low glycemic index (GI) diet has been associated with improved glycemic control in type 2 diabetes patients and a reduced risk of cardiovascular disease (CVD).
- Conditions
- Body Weight, Obesity, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- NCT02557022
- Testing
- GI and/or GL
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Myocardial Infarction
Smart Device-based Cardiac Rehabilitation After Myocardial Intervention
The aim of this study is to evaluate the influence of cardiac rehabilitation based on smart band use and telemonitoring on functional capacity change and risk factors control among patients hospitalized for acute myocardial…
- Trial name
- SmartRehab (NCT03926312)
- Testing
- Smart device-based cardiac rehabilitation
- Where
- Czechia
- Volunteers
- 64 people
- Sponsor
- Charles University, Czech Republic
Venous Thromboembolism
Risk of Recurrent Venous Thrombosis: A Validation Study of the Vienna Prediction Model
Because of a high recurrence risk after unprovoked venous thromboembolism (VTE) indefinite anticoagulation is recommended, but confers a considerable bleeding risk.
- Trial name
- NCT01972243
- Testing
- no intervention
- Where
- Austria
- Volunteers
- 800 people
- Sponsor
- Medical University of Vienna
Aortic Valve Stenosis
Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry
Multicenter registry data analysis of aortic valve stenosis patients that underwent elective, isolated transcutaneous aortic valve implantation (TAVI) or surgical aortic valve replacement between 2015 and 2019.
- Trial name
- AVALON (NCT05308173)
- Testing
- Surgical Aortic Valve Replacement, Transcutenous Aortic Valve Implantation
- Volunteers
- 2,393 people
- Sponsor
- Nicolaus Copernicus University
Fibrillation, Atrial, Atrial Fibrillation
Use Of SB424323 With Aspirin In Non-Valvular Atrial Fibrillation In Patients At A Low Or Intermediate Risk For Stroke
This study will allow determination of the pharmacokinetic and pharmacodynamics of SB424323 in a relevant population. The data from this study will be used along with other data to aid in choosing the most appropriate dose for…
- Trial name
- NCT00240643
- Testing
- SB424323
- Where
- 116 sites in United States, Argentina and 23 more
- Volunteers
- 640 people
- Sponsor
- GlaxoSmithKline
Aortic Valve Stenosis
TAVI in LOW RISK in the REAL WORLD
The primary objective is to assess all-cause mortality, the occurrence of stroke, or rehospitalization for cardiovascular causes in low-risk "all-comers" patients following percutaneous aortic valve replacement
- Trial name
- TAVI IN LOW R (NCT07605780)
- Where
- Italy
- Volunteers
- 650 people
- Sponsor
- Centro Cardiologico Monzino
Antiphospholipid Syndrome (APS), Venous Thrombosis (Disorder)
Observational Study to Evaluate the Effectiveness of DOACS for Secondary Thrombosis Prevention in Low-risk Thrombotic APS Patients
This is an observational study designed to evaluate the effectiveness and safety of direct oral anticoagulants (DOACs) compared with vitamin K antagonists (VKAs) for the secondary prevention of thrombosis in patients with…
- Conditions
- Antiphospholipid Syndrome (APS), Venous Thrombosis (Disorder), Thrombophilia
- Trial name
- DOACS-APS (NCT07372170)
- Where
- 2 sites in Spain
- Volunteers
- 600 people
- Sponsor
- Infanta Leonor University Hospital
Metabolic Syndrome, Coronary Heart Disease
Hämeenlinna Metabolic Syndrome Research Program: Surrogate Indicators for Atherosclerosis
Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS) surrogate indicators for atherosclerosis are studied in 120 men with…
- Trial name
- HMS-02 (NCT01119404)
- Where
- 4 sites in Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kanta-Häme Central Hospital
Deep Vein Thrombosis
Understanding Risk Factors Involved in Developing a Second Blood Clot.
The purpose of this study is to develop a way to predict which patients diagnosed with idiopathic blood clots can safely stop warfarin therapy after six months.
- Trial name
- NCT00261014
- Where
- 7 sites in Canada, France
- Volunteers
- 800 people
- Sponsor
- Ottawa Hospital Research Institute
Obesity
Low Carb Diets & Exercise for Cardiovascular Disease (CVD) Reduction
The purposes of this study are: To investigate the effects of a 6 month low carbohydrate diet in obese men on markers of heart health including blood fats, blood clotting factors, inflammatory markers and levels of body fat.
- Trial name
- NCT01176084
- Testing
- low carbohydrate diet, low carbohydrate diet and exercise
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Type 2 Diabetes, Obesity
Canola-Mediterranean Diet Study in T2DM
The purpose of the study is to assess whether a Mediterranean-type weight-loss diet, enriched with canola oil, high in plant protein, and low in carbohydrates will produce blood sugar control, reduce coronary heart disease (CHD)…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Cardiovascular Diseases
- Trial name
- NCT02245399
- Testing
- A canola oil enriched mediterranean diet, A high wheat fiber diet
- Where
- 3 sites in Canada
- Volunteers
- 164 people
- Sponsor
- Unity Health Toronto
Dipeptidyl-Peptidase 4 Inhibitors, LDL Cholesterol
Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial
The purpose of this study is to determine whether Anagliptin or Sitagliptin are effective in reducing the low-density lipoprotein cholesterol in patients with type 2 diabetes and cardiovascular risk factors on statin.
- Conditions
- Dipeptidyl-Peptidase 4 Inhibitors, LDL Cholesterol, Glycosylated Hemoglobin, Diabetes Mellitus
- Trial name
- REASON (NCT02330406)
- Testing
- Anagliptin, Sitagliptin
- Where
- Japan
- Volunteers
- 353 people
- Sponsor
- Institute for Clinical Effectiveness, Japan
Atrial Fibrillation
Clinical and Laboratory Predictors Associated With Stroke or Systemic Embolism in Low Risk Atrial Fibrillation Patients
The purposes of this study are to assess the prevalence of patients with a low risk of stroke or systemic embolism based on a CHA2DS2-VASc score among patients who have an AF-related thromboembolism and to identify the clinical…
- Trial name
- CLASS-AF (NCT03147911)
- Where
- 9 sites in South Korea
- Volunteers
- 1,181 people
- Sponsor
- Korea University Guro Hospital
Cardiovascular Risk Factor
Impact of Plant Sterol Supplement on LDL-C Lowering in Low-to-Moderate Risk South Asian Patients
The purpose of this study is to measure the incremental effectiveness of a twice daily plant sterol supplement in a population of South Asian patients who have low-to-moderate cardiovascular disease (CVD) risk.
- Trial name
- NCT04030247
- Testing
- Plant Sterol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
New Onset Atrial Fibrillation
Anticoagulant and Antiarrhythmic Management Based on Continuous Rhythm Monitoring
This pilot study aims to assess the feasibility and safety of using an ILR to identify the incidence of recurrent AF after an episode of newly diagnosed AF.
- Trial name
- NCT04038944
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- St. Francis Hospital, New York
Diabetes
Optimizing Statin Tratment in People Living With Diabetes
Hypercholesterolemia is frequent (prevalence of 30% in general population) and constitue with diabetes, obesity and arterial hypertension a major risk factor of atherosclerosis that leads to cardiovascular diseases (CVD).
- Trial name
- MEDPHARM-RCV (NCT04320719)
- Where
- France
- Volunteers
- 387 people
- Sponsor
- University Hospital, Montpellier
Arterial Hypertension
"Community-based, eHealth Supported Management of Cardiovascular Risk Factors by Lay Village Health Workers (ComBaCaL aHT TwiC 1 & ComBaCaL aHT TwiC 2)
ComBaCaL aHT TwiC 1 and aHT TwiC 2 are two cluster-randomized controlled trials that are identical in intervention, design and endpoints.
- Trial name
- NCT05684055
- Testing
- First-line antihypertensive single-pill combination (SPC), Standardized counselling and referral to the closest health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- 1,354 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 2 Diabetes, Heart Diseases
Egg Intake and Risk of Type 2 Diabetes
This is a longitudinal study that will collect demographic, anthropometric and dietary data to determine the relationships between meat and egg intake and the incidence of Type 2 Diabetes.
- Trial name
- ES (NCT03406910)
- Where
- United States
- Volunteers
- 55,851 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Syndrome, Vascular Disorders
Optimal Timing of Physical Activity in Cancer Treatment
The number of long-term cancer survivors is growing. As a result, treatment-related morbidity - such as cardiovascular disease, metabolic syndrome, functional decline and fatigue - is impacting quality of life and impairing…
- Conditions
- Metabolic Syndrome, Vascular Disorders, Cardiovascular Risk Factors, Fatigue
- Trial name
- ACT (NCT01642680)
- Testing
- A tailored physical activity program during chemotherapy, A tailored physical activity program after chemotherapy
- Where
- Netherlands
- Volunteers
- 266 people
- Sponsor
- University Medical Center Groningen