Clinical trials: Low Cardiovascular Risk
Dyslipidemia
Statins at the Primary Care Level
Hypercholesterolemia, a major cause of disease burden in both the developed and developing world, is estimated to cause 2.6 million deaths annually (4.5% of all deaths) and one third of ischemic heart diseases., and result in…
- Trial name
- EPRINA (NCT02380911)
- Testing
- Educational Intervention
- Where
- 10 sites in Argentina
- Volunteers
- 357 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Aortic Valve Stenosis, Cardiovascular Diseases
Comparison of TAVR With SAVR in Younger Low Surgical Risk Patients With Severe Aortic Stenosis
A randomized clinical trial investigating transcatheter (TAVR) versus surgical (SAVR) aortic valve replacement in patients 75 years of age or younger suffering from severe aortic valve stenosis.
- Conditions
- Aortic Valve Stenosis, Cardiovascular Diseases, Heart Diseases, Heart Valve Diseases
- Trial name
- NOTION-2 (NCT02825134)
- Testing
- Transcatheter aortic valve replacement, Surgical aortic valve replacement
- Where
- 9 sites in Denmark, Finland and 3 more
- Volunteers
- 376 people
- Sponsor
- Ole De Backer
Coronary Arteriosclerosis, Diabetes Mellitus, Type 2
Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)
Physicians tend to always use the lowest dose of statins to initiate therapy even in subjects who require large reductions in cholesterol.
- Conditions
- Coronary Arteriosclerosis, Diabetes Mellitus, Type 2, Cerebrovascular Accident, Dyslipidemia
- Trial name
- ACTFAST (NCT00442845)
- Testing
- Atorvastatin (Lipitor)
- Where
- 121 sites in Cameroon, Canada and 3 more
- Volunteers
- 2,080 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Leukemia, Lymphoma, Low-Grade
Study of Low Intensity Conditioning and Immunotherapy for High-Risk Cancers of the Blood
This research project will focus on whether it is safe and effective to rely on donor cells to prevent relapse of leukemia, lymphoma, or other blood cancer after bone marrow stem cell transplant.
- Conditions
- Leukemia, Lymphoma, Low-Grade, Lymphoma, Non-Hodgkin's, Multiple Myeloma
- Trial name
- NCT00143884
- Testing
- Reduced intensity conditioning, Prophylactic donor leukocyte infusions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan Rogel Cancer Center
Fontan Procedure
Clinical Outcomes in Fenestrated Extra-Cardiac Fontan in Low Preoperative Risk Profiles
Evaluation of fenestration benefit in Extra-cardiac total cavo-pulmonary connection (Fontan procedure) in single ventricle anomaly, comparing clinical outcomes of patients with low preoperative risk profiles in prospective study
- Trial name
- NCT03503032
- Testing
- Extracardiac Fontan, Fontan fenestration
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Hypertension
Coaching and Navigation by Community Health Workers (CHWs) Through Telehealth for High-risk Hypertension
The investigators propose an intervention that leverages the success of Community Healthcare Workers (CHWs) and telehealth to connect patients with severe hypertension from Emergency Department (ED) to primary care resources and…
- Trial name
- CONNECT-HTN (NCT07461415)
- Testing
- CONNECT-HTN, Standard ED management
- Where
- 5 sites in Pakistan
- Volunteers
- 3,620 people
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Embolism, Lung Diseases
Identifying Low-Risk Patients With Pulmonary Embolism
To develop a clinical prediction rule to identify patients with acute pulmonary embolism who are at very low risk for short-term adverse outcomes.
- Trial name
- NCT00086151
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome X
Comparison of Two Different Diets on Health Outcomes
The purpose of this study is to compare the effects of a low-carbohydrate diet and a high-carbohydrate, high-fiber diet, on insulin sensitivity and blood chemicals considered risk markers for heart disease, in persons with the…
- Trial name
- NCT00269646
- Testing
- Low-carbohydrate and high-carbohydrate diets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Insulin Sensitivity
The Potential of Carnosine Supplementation in Reducing the Cardiometabolic Risk
The aim of this study is to determine whether carnosine supplementation in overweight/obese individuals can improve insulin secretion and/or insulin resistance by decreasing sub clinical inflammation.
- Trial name
- NCT02686996
- Testing
- carnosine
- Where
- Australia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Monash University
Atrial Fibrillation, Stroke
Transesophageal Echocardiography to Identify pAtients With Low Risk of Stroke in Atrial Fibrillation - TIARA Pilot Study
In this multi centre pilot study we will perform TEE in patients with AF who are eligible for VKA treatment. TTE will be used as pre-screening: if TTE shows left atrial abnormalities or aortic plaque, patients will be excluded…
- Trial name
- TIARA (NCT00224757)
- Testing
- Transoesophageal echocardiography
- Where
- 10 sites in Netherlands
- Volunteers
- 227 people
- Sponsor
- The Interuniversity Cardiology Institute of the Netherlands
Heart Diseases, Coronary Artery Disease
Intraoperative Echocardiography in Low-Risk CABG Surgery
This goal of this study is to better understand when and where intraoperative transesophageal echocardiography (TEE) should (or should not) be used during coronary artery bypass graft (CABG) surgeries.
- Conditions
- Heart Diseases, Coronary Artery Disease, Chest Pain, Stenosis Coronary
- Trial name
- NCT06154265
- Testing
- TEE probe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Chronic Stable Angina
Multi-slice CT Coronary Angiography in Patients With Stable Angina
early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as CT coronary angiography.
- Trial name
- NCT03963609
- Testing
- multisclice CT
- Volunteers
- 150 people
- Sponsor
- Benha University
Pre-eclampsia, Intra-uterine Growth Restriction
Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy
Pre-eclampsia and intra uterine growth restriction (IUGR) represent major complications for pregnant women, with a high related maternal and fetal morbidity and mortality.
- Conditions
- Pre-eclampsia, Intra-uterine Growth Restriction, Placental Insufficiency, 3D Doppler Ultrasound
- Trial name
- PLACENTA3D (NCT00930397)
- Where
- France
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection
Lung Cancer Prevention Screening Programme in Italy
This prospective randomized multicentered clinical study aims at implementing early diagnosis of lung cancer in high-risk heavy smokers in the Italian population.
- Conditions
- Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection, Cardiovascular Diseases
- Trial name
- RISP (NCT05766046)
- Testing
- early lung cancer detection, blood test
- Where
- Italy
- Volunteers
- 7,324 people, healthy volunteers welcome
- Sponsor
- Ugo Pastorino
Chronic Myeloproliferative Disorders, Leukemia
Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and busulfan, before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00296023
- Testing
- anti-thymocyte globulin, filgrastim, therapeutic allogeneic lymphocytes
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Dyslipidemia
Effect of Compound (Cardiol Forte) on Lipid And Glycemic Parameters in Low Cardiovascular Risk Individuals
This study will evaluate the effects of a combination dietary supplement, Cardiol Forte, on lipid and glycemic parameters in adults at low cardiovascular risk with suboptimal cholesterol levels.
- Trial name
- CLARISKI (NCT07515573)
- Testing
- Cardiol Forte
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- U.G.A. Nutraceuticals
Hypertension
Study of the Impact of Low Fat Dairy and High Fat Dairy Consumption on Daytime Ambulatory Blood Pressure
Market trends depicted by Agriculture and Agri-Food Canada suggest stagnation in cheese consumption, with potentially important impact on this key industry in Canada.
- Trial name
- GABA2 (NCT02763930)
- Testing
- Control diet, Milk diet, GABA-rich cheese diet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University