Clinical trials: Low Cardiovascular Risk
Atherosclerotic Cardiovascular Disease (ASCVD)
Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment
The goal of this clinical trial is to learn whether an ultra-low LDL-C target (<1.0 mmol/L) can improve clinical outcomes compared with a moderately low LDL-C target (1.0-1.39 mmol/L) in Chinese patients with extreme-high-risk…
- Trial name
- TARGET-EXTREME (NCT07615296)
- Testing
- Lipid-lowering therapy targeting LDL-C <1.0 mmol/L, Lipid-lowering therapy targeting LDL-C 1.0-1.39 mmol/L
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Beijing Anzhen Hospital
Pulmonary Arterial Hypertension, Air Pollution
The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension
With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary…
- Conditions
- Pulmonary Arterial Hypertension, Air Pollution, Maternal Outcome
- Trial name
- NCT07164157
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Wei Huang
Urinary Stones, Hypertension
The Links Between Water and Salt Intake, Body Weight, Hypertension and Kidney Stones: a Difficult Puzzle
Nephrolithiasis is a disease that strikes roughly 10% of the Italian population and its incidence in industrialized countries is on the increase.
- Conditions
- Urinary Stones, Hypertension, Overweight, Obesity
- Trial name
- NCT01100580
- Testing
- low salt diet, water therapy
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Parma
Coronary Artery Disease
Study Of Costs Realized After Percutaneous Coronary intervenTion Employing Same Day Discharge
The purpose of this study is to determine whether the total costs of care associated with uncomplicated elective or low-risk urgent percutaneous coronary intervention (PCI) through 30-day follow up are lower among patients who…
- Trial name
- SOCRATES (NCT02207270)
- Testing
- Same day discharge, Overnight Stay
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Trinity Health Michigan
Coronary Artery Disease, Chest Pain
The Value of CT-FFR Compared to CCTA or CCTA and Stress MPI in Low to Intermediate Risk ED Patients With Toshiba CT-FFR
Coronary Computed Tomography Angiogram (CCTA) is a non-invasive imaging modality that has high sensitivity and negative predictive value for the detection of coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction
- Trial name
- NCT03329469
- Testing
- Toshiba CT-FFR
- Where
- United States
- Volunteers
- 1,142 people
- Sponsor
- Northwell Health
Myocardial Infarction
Safety And Feasibility of Early DischargE - a Prospective And Randomized Trial of Low-risk Primary Percutaneous Coronary Intervention (PCI) Patients
The purpose of this study is to determine if early hospital discharge (at 48-72 hours), is feasible, safe, cost-effective, and/or improves compliance with medications, positive lifestyle changes and quality-of-life, in low-risk…
- Trial name
- SAFE-DEPART (NCT00474214)
- Testing
- Early hospital discharge facilitated by close nurse practitioner follow-up
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Hamilton Health Sciences Corporation
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
High Cardiovascular Risk Patients, Low Cardiovascular Risk Patients
Retinal Microvascularization and Cardiovascular Disease
The main objective of this study is to investigate whether there are links between the blood vessels of the retina as a whole and heart and/or vascular diseases (cardiovascular diseases).
- Trial name
- NESTOR (NCT03551717)
- Testing
- Optical Coherence Tomography angiography, Fundus, cardiac ultrasound scan
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Obstructive Sleep Apnea, Pregnancy Induced Hypertension
Sleep Quality in Pregnancy and Its Impact on Pregnancy Outcomes
Hypothesis:Sleep Disorders are very common during pregnancy but the their exact role in causation of pregnancy related disorders is yet to be determined.
- Conditions
- Obstructive Sleep Apnea, Pregnancy Induced Hypertension, High-Risk Pregnancy, Restless Leg Syndrome
- Trial name
- NCT02016638
- Testing
- Polysomnography and ambulatory blood pressure recording
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Atrial Fibrillation
Left Atrial Low vOltage Zone, GenetIC Markers and Outcomes in Patients After Atrial Fibrillation abLation
This prospective, single-centre cohort study aims to investigate the association between known genetic Atrial Fibrillation (AF) risk variants and the amount of left atrial fibrosis found in patients undergoing clinically…
- Trial name
- LOGICAL (NCT02074826)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technische Universität Dresden
Stenoses, Aortic
SAfe and Fast Discharge With Acurate Valve in Low Risk tavI Patients
Recent evidence from scientific literature supported the extension of TAVI procedures to lower risk populations. Despite its widespread usage, the expansion of TAVI into lower risk patient populations is still limited by…
- Trial name
- SAFARI (NCT05983458)
- Testing
- Transaortic valve replacement
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Maria Cecilia Hospital
Diabetes
Meta-analysis of Low GI/GL Diets and Cardiometabolic Risk in Diabetes
Low glycemic index and low glycemic load diets have been shown to improve glycemic control and cardiometabolic risk factors in randomized controlled trials in people with diabetes and are associated with reduced incidence of…
- Trial name
- NCT04045938
- Testing
- Low Glycemic Index or Glycemic Load
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Acute Coronary Syndrome
Impact of a Decision Aid on Patient Decision Making in Emergency Department Chest Pain Patients
We are doing a study to assess the impact of including patients in making decision regarding their own medical care in the emergency department. We will randomly assign them to either receive a decision aid or usual care.
- Trial name
- NCT01077037
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Mayo Clinic
Healthy Adult Participants
Effect of Low-Carbohydrate Versus Balanced Diets on Anthropometric Blood Pressure, ApoB, and hsCRP in Healthy Adults
The goal of this clinical trial is to explore the effect of a low-carbohydrate diet and a balanced diet. The main questions it aims to answer are: Does a 4-week diet intervention improve anthropometric and cardiovascular…
- Trial name
- NCT07457827
- Testing
- Diet
- Where
- 3 sites in Indonesia
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Trisakti University
Cardiac Disease, Cardiac Failure
Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery
The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery
- Conditions
- Cardiac Disease, Cardiac Failure, Cardiac Surgery, Inotropes
- Trial name
- NCT04635293
- Testing
- preoperative infusion of levosimendan, no preoperative infusion of levosimendan
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aretaieion University Hospital
Carbohydrate, Hypoxia
Isolated and Combined Effect of a Low Carbohydrate Diet and Exercise in Hypoxia in Patients With Type 2 Diabetes
The purpose of this study is to determine the effects of isolated chronic exercise in hypoxia and combined exercise in hypoxia with a low carbohydrate diet on hypoxia-induced transcription factor (HIF1-α); glycaemic control and…
- Conditions
- Carbohydrate, Hypoxia, Exercise, Diabetes Mellitus, Type 2
- Trial name
- NCT05094505
- Testing
- Exercise in normoxia, Control diet, Exercise in hypoxia
- Where
- 2 sites in Portugal
- Volunteers
- 42 people
- Sponsor
- Universidade do Porto
Myocardial Infarction
Safety of Early Discharge Following Low Risk Myocardial Infarction
Objectives: The primary objective of this study is to evaluate the safety of an early discharge strategy in patients with low risk ST-elevation myocardial infarction (STEMI), treated with primary percutaneous coronary…
- Trial name
- EDAMI (NCT01868256)
- Testing
- early discharge (<72 h), Conventional discharge
- Where
- Spain
- Volunteers
- 1,558 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Non ST Segment Elevation Myocardial Infarction, Unstable Angina
Patients With High-risk Acute Coronary Syndrome Without ST-segment Elevation
This non-inferiority study aims at comparing Versa® to the reference enoxaparin (Clexane®, Sanofi-Aventis) in patients with high-risk unstable angina and NSTEMI.
- Trial name
- VECOR (NCT01356992)
- Testing
- Enoxaparin
- Where
- 5 sites in Brazil
- Volunteers
- 62 people
- Sponsor
- Eurofarma Laboratorios S.A.
Hypertension
Evaluation of the Effectiveness of an Intervention to Reduce Gaps in Hypertension Care in Low-income Medellin, Colombia
This study evaluates the effectiveness of a multi-component intervention to reduce the gaps in hypertension care and control at a population level in low-income Communes of Medellin, Colombia, and assess the process and fidelity…
- Trial name
- NCT05011838
- Testing
- 1. Health Services Redesign, 2. Clinical Staff Training, 3. Patient and Community Engagement
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium