Clinical trials: Low Cardiovascular Risk Patients
Patient With Dyslipidemia
Assessment of Compliance With European and French Guidelines for the Management of Dyslipidaemias
Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and of disability-adjusted life years in Europe, and is also increasingly common in…
- Trial name
- OBDYSLIP (NCT03449784)
- Testing
- Detection of patients with dyslipidemia
- Where
- France
- Volunteers
- 977 people
- Sponsor
- University Hospital, Montpellier
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Atrial Fibrillation, Arrhythmias, Cardiac
Low Workload Concept for the Detection of Silent Atrial Fibrillation (AF) and Atrial Fibrillation Burden in Patients At High Risk of AF and Stroke
Patient-centered novel e-health technology and services will lay the foundation for future healthcare systems and services to support health and welfare promotion.
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- CARE-DETECT (NCT05351775)
- Testing
- Smartphone application, Bed sensor, Wrist-worn photoplethysmography (PPG) and accelerometer data logger.
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- University of Turku
Pre Diabetes, ASCVD
Comparison of Low-Intensity Statin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus (PROVE-DM)
This study is to evaluating the impact of low-intensity statin plus ezetimibe versus high-intensity statin therapy on risk of new-onset diabetes mellitus in patients with atherosclerotic cardiovascular disease who have…
- Trial name
- NCT05579626
- Testing
- high-intensity statin arm, low-intensity statin plus ezetimibe
- Where
- 31 sites in South Korea
- Volunteers
- 4,000 people
- Sponsor
- Seung-Whan Lee, M.D., Ph.D.
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Dual Antiplatelet Therapy Escalation From Standard-dose Clopidogrel to Low-Dose Prasugrel in Patients With High Bleeding and Ischemic Risk Undergoing PCI: A Prospective, Randomized Pharmacodynamic Study (TAILOR-BLEED-2)
The primary aim of this study is to investigate the PD effects of switching from standard-dose clopidogrel dose to low-dose prasugrel versus continuing standard-dose clopidogrel in patients at dual-risk (HBR defined as the…
- Trial name
- NCT07025148
- Testing
- Prasugrel, Clopidogrel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Venous Thromboembolism, Venous Thrombosis
Intermittent Pneumatic Compression in Surgical Patients at Extremely-high Risk for Venous Thromboembolism
The aim of the study is to evaluate efficacy and safety of venous thromboembolism prophylaxis by the combination of graduated compression stockings (GCS), standard doses of low-molecular-weight heparins (LMWH) and sequential…
- Trial name
- IPCSUPER (NCT03044574)
- Testing
- SCD, GCS, LMWH
- Where
- 2 sites in Russia
- Volunteers
- 407 people
- Sponsor
- Pirogov Russian National Research Medical University
Atherosclerotic Cardiovascular Disease (ASCVD)
Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment
The goal of this clinical trial is to learn whether an ultra-low LDL-C target (<1.0 mmol/L) can improve clinical outcomes compared with a moderately low LDL-C target (1.0-1.39 mmol/L) in Chinese patients with extreme-high-risk…
- Trial name
- TARGET-EXTREME (NCT07615296)
- Testing
- Lipid-lowering therapy targeting LDL-C <1.0 mmol/L, Lipid-lowering therapy targeting LDL-C 1.0-1.39 mmol/L
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Valve Stenosis
Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality
Randomized controlled, multi-center trial randomizing patients with symptomatic severe aortic stenosis at low to intermediate operative risk of mortality in a 1:1 fashion to transcatheter aortic valve implantation (TAVI) or…
- Trial name
- DEDICATE (NCT03112980)
- Testing
- Transcatheter aortic valve implantation, Surgical aortic valve replacement
- Where
- 43 sites in Germany
- Volunteers
- 1,414 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mitral Regurgitation
TEER for Severe DMR of Low to Intermediate Surgery Risk
To investigate the efficacy and safety of transcatheter mitral valve edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR) patients of low to intermediate surgery risk.
- Trial name
- NCT06162780
- Testing
- ultrasonic cardiography (UCG), TEER
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dyslipidemia
Statins at the Primary Care Level
Hypercholesterolemia, a major cause of disease burden in both the developed and developing world, is estimated to cause 2.6 million deaths annually (4.5% of all deaths) and one third of ischemic heart diseases., and result in…
- Trial name
- EPRINA (NCT02380911)
- Testing
- Educational Intervention
- Where
- 10 sites in Argentina
- Volunteers
- 357 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Heart Failure
Trial to Determine Imaging Parameters of LMI1195 in Heart Failure Patients at Low and High Risk of Defibrillator Firing
The purpose of this clinical study is to determine the optimal imaging parameters and assess the safety of LMI1195 -101 in Heart Failure subjects at Low and High Risk of cardiac events.
- Trial name
- LMI1195-201 (NCT01085175)
- Testing
- LMI 1195
- Where
- United States
- Sponsor
- Lantheus Medical Imaging
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Cardiac Disease, Cardiac Failure
Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery
The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery
- Conditions
- Cardiac Disease, Cardiac Failure, Cardiac Surgery, Inotropes
- Trial name
- NCT04635293
- Testing
- preoperative infusion of levosimendan, no preoperative infusion of levosimendan
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aretaieion University Hospital
Myocardial Infarction
Safety of Early Discharge Following Low Risk Myocardial Infarction
Objectives: The primary objective of this study is to evaluate the safety of an early discharge strategy in patients with low risk ST-elevation myocardial infarction (STEMI), treated with primary percutaneous coronary…
- Trial name
- EDAMI (NCT01868256)
- Testing
- early discharge (<72 h), Conventional discharge
- Where
- Spain
- Volunteers
- 1,558 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Carbohydrate, Hypoxia
Isolated and Combined Effect of a Low Carbohydrate Diet and Exercise in Hypoxia in Patients With Type 2 Diabetes
The purpose of this study is to determine the effects of isolated chronic exercise in hypoxia and combined exercise in hypoxia with a low carbohydrate diet on hypoxia-induced transcription factor (HIF1-α); glycaemic control and…
- Conditions
- Carbohydrate, Hypoxia, Exercise, Diabetes Mellitus, Type 2
- Trial name
- NCT05094505
- Testing
- Exercise in normoxia, Control diet, Exercise in hypoxia
- Where
- 2 sites in Portugal
- Volunteers
- 42 people
- Sponsor
- Universidade do Porto
Coronary Artery Disease
Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention
The proposed study aims to assess the antiplatelet effects of more potent oral P2Y12 inhibition with low-dose ticagrelor (60 mg bid) compared with standard of care clopidogrel in patients with a high ABCD-GENE score (≥10).
- Trial name
- NCT06228456
- Testing
- Ticagrelor 60mg, Clopidogrel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Coronary Artery Disease, Chest Pain
The Value of CT-FFR Compared to CCTA or CCTA and Stress MPI in Low to Intermediate Risk ED Patients With Toshiba CT-FFR
Coronary Computed Tomography Angiogram (CCTA) is a non-invasive imaging modality that has high sensitivity and negative predictive value for the detection of coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction
- Trial name
- NCT03329469
- Testing
- Toshiba CT-FFR
- Where
- United States
- Volunteers
- 1,142 people
- Sponsor
- Northwell Health
Deep Vein Thrombosis, Pulmonary Embolism
D-dimer to Select Patients With First Unprovoked Venous Thromboembolism Who Can Have Anticoagulants Stopped at 3 Months
The purpose of this study is to determine if the risk of recurrent venous thromboembolism (VTE) after stopping therapy is low and acceptable in patients with a first unprovoked proximal deep vein thrombosis (DVT) or pulmonary…
- Trial name
- DODS (NCT00720915)
- Testing
- Discontinue anticoagulant therapy (Negative d-dimer), Continue on anticoagulant therapy (positive d-dimer)
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 410 people
- Sponsor
- McMaster University
Cardiovascular Risk Factor
Impact of Plant Sterol Supplement on LDL-C Lowering in Low-to-Moderate Risk South Asian Patients
The purpose of this study is to measure the incremental effectiveness of a twice daily plant sterol supplement in a population of South Asian patients who have low-to-moderate cardiovascular disease (CVD) risk.
- Trial name
- NCT04030247
- Testing
- Plant Sterol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Aortic Valve Stenosis, Heart Valve Diseases
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treating patients with symptomatic, severe native aortic stenosis who are considered…
- Conditions
- Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder
- Trial name
- ENVISION (NCT05932615)
- Testing
- Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System
- Where
- 107 sites in United States, Australia and 11 more
- Volunteers
- 1,500 people
- Sponsor
- Abbott Medical Devices