Clinical trials: Low Dose
Low Level Laser Therapy, Performance
Photobiomodulation in Different Doses on Strength Capacities and Functional Performance
Background: Photobiomodulation has been explored for years, with wide clinical use for wound healing and analgesia in varied orthopedic conditions, but the number of research and clinical use has increased during the last decade.
- Conditions
- Low Level Laser Therapy, Performance, Sport
- Trial name
- NCT03860766
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Low Dose Calcium to Prevent Preeclampsia
The purpose of this study is to assess, in pregnant women with calcium-poor diets, what is the effectiveness of low-dose (500 mg/day) calcium supplements associated with an educational intervention, compared to the educational…
- Conditions
- Pre-Eclampsia, Hypertension, Pregnancy-Induced, Dietary Calcium Deficiency
- Trial name
- AMCAL (NCT02338687)
- Testing
- calcium, Educational sessions
- Where
- Brazil
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Myopia
The Effects of Low-dose Atropine and Orthokeratology in Pediatric Myopia Control
Both orthokeratology and atropine eye drops are effective methods for myopia control, but few studies have compared them all together simultaneously.
- Trial name
- AVO (NCT05478356)
- Testing
- low-dose atropine eye drops, orthokeratology
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Evidence Based Cataract Study Group
Brain Tumor
Effect of Preemptive Low Dose Norepinephrine Infusion on Intraoperative Hemodynamic Stability and Postoperative Outcomes in Patients Undergoing Brain Tumor Resection With a Craniotomy
In the experimental group, norepinephrine at a concentration of 5 mcg/ml is preemptively administered through peripheral venous catheter with a size of 20 G or more from the time of anesthesia induction to the end of anesthetic…
- Trial name
- NCT05814601
- Testing
- norepinephrine
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
FLT3 Gene Mutation Negative, FLT3 Internal Tandem Duplication Positive
Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
This phase I/II trial studies the side effects and best dose of quizartinib when given in combination with azacitidine or cytarabine in treating patients with acute myeloid leukemia or myelodysplastic syndrome that have come back…
- Conditions
- FLT3 Gene Mutation Negative, FLT3 Internal Tandem Duplication Positive, Recurrent Acute Myeloid Leukemia, Recurrent Chronic Myelomonocytic Leukemia
- Trial name
- NCT01892371
- Testing
- Azacitidine, Cytarabine, Quizartinib
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer (CRC)
Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer
This is a prospective, open-label, randomized, parallel-group phase II trial evaluating the efficacy and safety of a low-dose radiotherapy sensitization strategy combined with a PD-1 antibody (pucotenlimab) and CAPEOX as…
- Trial name
- NCT07448142
- Testing
- Low-dose radiotherapy, Pucotenlimab, CAPEOX/XELOX
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Kidney Transplantation
Ultra-low Dose Subcutaneous IL-2 in Renal Transplantation
To investigate the safety and tolerability of treatment with low dose rIL-2 in renal transplant recipients. To assess the immunologic impact of low dose rIL-2 in renal transplant recipients.
- Trial name
- NCT02417870
- Testing
- aldesleukin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anil K. Chandraker, MD
Opioid Use Disorder
Pharmacokinetics, Safety, and Tolerability of Depot Buprenorphine at Three Different Molecular Weights in Treatment-Seeking Subjects With Opioid Use Disorder
This is a single-center, randomized, open-label, single-dose, parallel-group study which will enroll and randomize approximately 48 subjects (to achieve 36 completers) with opioid use disorder (OUD) who are seeking treatment for…
- Trial name
- NCT02559973
- Testing
- RBP-6000, SUBOXONE Sublingual Film
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Indivior Inc.
Irreversible Intestinal Failure, Allograft Rejection
Low Dose Irradiation for Small Bowel Transplant
The specific aims of this study is to improve short and long-term patient and graft survival, to reduce the incidence and severity of allograft rejection, to reduce the incidence of infection and to reduce and/or eventually…
- Trial name
- NCT00382486
- Testing
- Reduce the risk of allograft rejection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Prostate Cancer
HDR Brachytherapy vs. LDR Brachytherapy Monotherapy in Localized Prostate Cancer
High-dose rate brachytherapy (HDRB) used as monotherapy is emerging as an alternative to Low-Dose Rate brachytherapy (LDRB) with excellent PSA-progression free survival as high as 90-100% for favorable prostate cancer at a median…
- Trial name
- HDRvsLDR (NCT02628041)
- Testing
- Permanent Iodine-125 seed implant, High-Dose-rate Prostate Brachytherapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- CHU de Quebec-Universite Laval
Acne Vulgaris
Combined Low-Dose Isotretenion and Long-Pulsed 1064 ND-YAG Laser in the Treatment of Acne Erythema
Acne erythema consists of telangiectasia and erythematous papules, without a comedo, which occurs as a result of inflammatory acne.
- Trial name
- NCT05622253
- Testing
- Combined Low-Dose Isotretenion and Long-Pulsed 1064 ND-YAG Laser
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Solid Tumor
Safety and Tolerability of LDRT Plus Concurrent Partial SBRT and Tislelizumab in Patients With Bulky Tumors
This is a 3+3 dose escalation phase I study which aims to evaluate the safety and tolerability of low dose radiotherapy (LDRT) plus concurrent partial Stereotactic Ablative Radiotherapy (SBRT) and Tislelizumab in Patients with…
- Trial name
- NCT06349837
- Testing
- Tislelizumab, Low Dose Radiotherapy, Stereotactic Ablative Radiotherapy
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sichuan University
Myopia
Low-Dose Atropine for Treatment of Myopia
Study Objectives The objectives for this randomized trial are: 1. To determine the efficacy of daily low-dose atropine (0.01%) for slowing myopia progression over a two-year treatment period in children aged 5 to less than 13…
- Trial name
- MTS1 (NCT03334253)
- Testing
- Atropine
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- Jaeb Center for Health Research
Chronic Graft Versus Host Disease, Chronic GVHD
Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
This research study is a Phase I clinical trial, which tests the safety of an investigational combination of IL-2 plus donor anti-inflammatory Treg cells and also tries to define the appropriate dose of the investigational…
- Conditions
- Chronic Graft Versus Host Disease, Chronic GVHD, Complications of Organ Transplant Stem Cells
- Trial name
- NCT01937468
- Testing
- Treg-enriched infusion, Interleukin-2
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Dana-Farber Cancer Institute
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
Adult Acute Myeloid Leukemia in Remission, Childhood Acute Lymphoblastic Leukemia in Remission
Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer
This phase I/II trial studies whether a new kind of blood stem cell (bone marrow) transplant, that may be less toxic, is able to treat underlying blood cancer. Stem cells are "seed cells" necessary to make blood cells.
- Conditions
- Adult Acute Myeloid Leukemia in Remission, Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Childhood Myelodysplastic Syndrome
- Trial name
- NCT00027820
- Testing
- Fludarabine Phosphate, Total-Body Irradiation, Peripheral Blood Stem Cell Transplantation
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 106 people
- Sponsor
- Fred Hutchinson Cancer Center
Endometrial Hyperplasia, Endometrial Cancer
Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia
This study protocol evaluates the use of hysteroscopic endomyometrial resection in women diagnosed with atypical endometrial hyperplasia or grade I endometrial cancer who have not responded to anti-hormone therapy.
- Conditions
- Endometrial Hyperplasia, Endometrial Cancer, Gynecologic Cancer
- Trial name
- FETCH (NCT04362046)
- Testing
- Hysteroscopic uterine resection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vancouver Coastal Health Research Institute
Cancer, Metastatic Solid Malignancies
Consolidation Therapy in Patients With Metastatic Solid Malignancies
This study evaluates the effectiveness of Tumor Associated Peptide Antigens (TAPA) pulsed dendritic cell injections as a potential consolidation therapy for patients with metastatic solid malignancies (SM).
- Trial name
- NCT02705703
- Testing
- TAPA-pulsed DC vaccine
- Sponsor
- Kiromic BioPharma Inc.
Demoralization
Exploratory Study of Low Dose Psilocybin
The purpose of the present study is to evaluate the feasibility, initial signals of efficacy, and potential mechanisms of action of "microdoses" of psilocybin (i.e., low doses of psilocybin that are not believed to produce…
- Trial name
- NCT05227742
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Carcinoma, Non-Small-Cell Lung Cancer, Bone Metastases From Solid Tumors
Safety Study for a Gamma Delta T Cell Product Used With Low Dose Radiotherapy in Patients With Locally Advanced or Metastatic NSCLC or Solid Tumors With Bone Metastases
This is a clinical trial studying intravenous infusions of allogeneic gamma delta T cells after receiving low dose radiotherapy in participants with locally advanced or metastatic non-small cell lung cancer or solid tumors with…
- Trial name
- NCT06069570
- Testing
- KB-GDT-01
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Kiromic BioPharma Inc.
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