Clinical trials: Low Dose
PET/CT
Assessing Ultra-low Dose PET/CT and CT-less PET Using a Long Axial Field-of-view PET/CT System
Latest generation extended axial field-of-view (FOV) PET/CT systems offer the potential for substantial reductions in applied radiopharmaceutical necessary for a clinical scan.
- Trial name
- ULD-PET (NCT05496920)
- Testing
- FD-PET/CT, LD-PET/CT
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gastric or Duodenal Ulcers
Long-term Use of Takepron Capsules on the Prevention of Recurrence of Gastric/Duodenal Ulcer in Patients Receiving Low-dose Aspirin
The purpose of this study is to investigate the safety and efficacy of long-term administration of lansoprazole (Takepron) for up to 12 months in the routine clinical setting in patients receiving low-dose aspirin
- Trial name
- NCT02099682
- Testing
- Lansoprazole
- Volunteers
- 3,366 people
- Sponsor
- Takeda
Hemophilia A
Low Dose Emicizumab vs Low Dose Factor VIII in Prophylaxis in Hemophilia A Patients
Low dose factor VIII prophylaxis is practiced around the world. Role of standard dose Emicizumab prophylaxis is well established. Emicizumab is an expensive drug.
- Trial name
- AFEEL (NCT06938659)
- Testing
- Emicizumab Injection, Factor VIII (FVIII)
- Where
- Bangladesh
- Volunteers
- 20 people
- Sponsor
- Dhaka Medical College
Ovarian Cancer
Carboplatin Plus Paclitaxel With or Without Continued Low-Dose Paclitaxel in Treating Patients With Early-Stage Ovarian Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003644
- Testing
- carboplatin, paclitaxel
- Where
- 151 sites in United States, Japan
- Volunteers
- 571 people
- Sponsor
- Gynecologic Oncology Group
Lymphoma
Low-dose Radiotherapy for Diffuse Large B-cell Lymphoma
Patients with Diffuse Large B-cell Lymphoma with indication for palliative radiotherapy are treated with low-dose radiation (2 x 2 Gy) to the symptomatic sites only.
- Trial name
- NCT02803840
- Testing
- Low-dose radiotherapy
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Lung Cancer
Early Detection of Lung Cancer in Czech High-risk Asymptomatic Individuals
The aim of this study is to evaluate and optimize entry criteria for the proposed programme for early detection of lung cancer in the Czech Republic.
- Trial name
- ELEGANCE (NCT04627350)
- Testing
- Response to pulmonary finding (nodule, mass)
- Where
- Czechia
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Hemophilia C
A Single and Low Dose of Recombinant Factor VIIa in Patients With Severe Factor XI Deficiency Undergoing Surgery
Lately the investigators found that patients with severe factor XI deficiency and inhibitors could undergo major surgery with a single low dose of recombinant factor VIIa and tranexamic agent.
- Trial name
- rFVIIa (NCT01538160)
- Testing
- recombinant factor VIIa
- Where
- 3 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Sheba Medical Center
Breast Cancer
Evaluate Trastuzumab Plus Standard Chemotherapy Given Before Surgery in Breast Cancer Patients With Low HER 2 Expression
The purpose of this study is to find out if there is a benefit of adding Herceptin (trastuzumab) to standard chemotherapy in this type of breast cancer.
- Trial name
- NCT00944047
- Testing
- nab-paclitaxel, trastuzumab, Doxorubicin
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Kansas Medical Center
Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period
Ketamine and Postoperative Depressive Symptom-PASSION
Perioperative depression symptom (PDS) is one of the common mental comorbidity, and influences the clinical outcomes and prognosis. However, there is no rapid acting treatment to deal with it during the limited hospital stay.
- Trial name
- NCT03086148
- Testing
- Ketamine, Normal saline
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Tiantan Hospital
End Stage Renal Disease
Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis
OBJECTIVES: I. Evaluate whether hemodialysis providing a 2-pool, variable volume urea kinetic modelling value of 1.05 versus 1.45 reduces mortality and morbidity in patients with end stage renal disease. II.
- Trial name
- HEMO (NCT00004285)
- Testing
- Standard dose, low flux hemodialysis, Standard dose, high flux hemodialysis, High dose, low flux hemodialysis
- Where
- United States
- Volunteers
- 1,846 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Smoking Cessation
Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites
This study is to help determine the most effective type or combination of treatments to offer patients seeking lung cancer screening who are smokers to help them reduce the number of cigarettes they smoke, or quit smoking.
- Trial name
- NCT03315910
- Testing
- Motivational Interviewing (MI), Nicotine Replacement Therapy (NRT), Nicotine Lozenge
- Where
- 18 sites in United States
- Volunteers
- 807 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Myeloma
Lenalidomide & Adriamycin & Dexamethasone (RAD) in Newly Diagnosed, Multiple Myeloma Patients
This study is to assess the efficacy and safety of lenalidomide in combination with adriamycin and low dose dexamethasone in newly diagnosed patients with symptomatic multiple myeloma as well as to collect information regarding…
- Trial name
- RAD (NCT02471820)
- Testing
- Lenalidomide, Adriamycin, Dexamethasone
- Where
- 4 sites in Greece
- Volunteers
- 45 people
- Sponsor
- Meletios A. Dimopoulos
Hot Flashes, Sleep Disorders
Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function
To evaluate the tolerability, bleeding patterns and acceptability of Totelle® 1mg administered to a population of Brazilian women in a continuous combined regime for hormone replacement therapy.
- Trial name
- NCT00195520
- Testing
- Totelle®
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
COVID-19, Deep Vein Thrombosis
Evaluating Dose Regimen of Intravenous Unfractionated Heparin and Low Molecular Weight Heparin in Critical Ill Patients Versus Critical Ill COVID-19 Patients Using Anti-Xa Levels.
To see whether our increased dosing regimen of unfractionated heparin (UF) and low molecular weight heparin (LMWH) in COVID-19 patients was effective at preventing thrombo-embolic complications.
- Conditions
- COVID-19, Deep Vein Thrombosis, Anticoagulants and Bleeding Disorders, Critical Illness
- Trial name
- NCT05224388
- Testing
- Enoxaparin, Heparin
- Where
- Belgium
- Volunteers
- 813 people
- Sponsor
- University Hospital, Ghent
Epicardial Fat, Obesity
CT Evaluation of Cardiovascular Risk Markers in Obese Patients
Obesity is a chronic metabolic disorder : it leads to coronary heart disease and early atherosclerosis. Coronary artery calcium measured by CT is known as a robust predictor to predict risk for cardiac events in symptomatic and…
- Conditions
- Epicardial Fat, Obesity, Cardiovascular Risks Markers, Metabolic Syndrome
- Trial name
- RisqOScan (NCT03111693)
- Testing
- Unenhanced Coro-CT
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Clermont-Ferrand
Myelodysplastic Syndromes
Lenalidomide Versus Placebo in Myelodysplastic Syndromes With a Deletion 5q[31] Abnormality
The purpose of this study was to compare 2 doses (10 mg and 5 mg) of lenalidomide to that of placebo in subjects with red blood cell (RBC) transfusion-dependent low- or intermediate-1-risk IPSS MDS associated with a deletion…
- Trial name
- NCT00179621
- Testing
- Lenalidomide 5 mg, Lenalidomide 10 mg
- Where
- 38 sites in Belgium, France and 7 more
- Volunteers
- 205 people
- Sponsor
- Celgene Corporation
Poor Ovarian Response
Long-term Endogenous Androgen Priming in Bologna Criteria Poor Responder Patients - A Pilot Study
Until now no scientific clinical evidence exists regarding the possible impact of long term endogenous androgen priming in IVF patients aligned with the Bologna Criteria, in specific the impact of priming on serum parameters…
- Trial name
- NCT03447184
- Testing
- Androgen priming
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Mỹ Đức Hospital
Liver Transplantation
De Novo Everolimus Versus Tacrolimus in Combination With Mofetil Mycophenolate and Low Dose Corticosteroids to Reduce Tacrolimus Induced Nephrotoxicity in Liver Transplantation: a Prospective, Multicentric, Randomised Study
Tacrolimus is a calcineurin inhibitor. This is the immunosuppression of reference for patients undergoing a first liver transplant.
- Trial name
- FOREVER (NCT02909335)
- Testing
- Tacrolimus, Everolimus, Mycophenolate mofetil
- Sponsor
- Rennes University Hospital
Idiopathic Retroperitoneal Fibrosis, Perianeurysmal Retroperitoneal Fibrosis
Methotrexate as a Steroid-sparing Agent in Idiopathic Retroperitoneal Fibrosis: a Randomised, Multicenter Trial
Chronic periaortitis is a clinico-pathological entity encompassing idiopathic retroperitoneal fibrosis and perianeurysmal retroperitoneal fibrosis.
- Conditions
- Idiopathic Retroperitoneal Fibrosis, Perianeurysmal Retroperitoneal Fibrosis, Chronic Periaortitis
- Trial name
- FIPREDEX (NCT01240850)
- Testing
- Methotrexate+Prednisone, Prednisone
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Parma
Epiphora
Low-Dose Atropine Eye Drops for Excessive Tearing (Epiphora)
This study tests whether a very low concentration of atropine eye drops (0.005%) reduces excessive tearing (epiphora) in adults.
- Trial name
- NCT07816224
- Testing
- Atropine sulfate ophthalmic solution 0.005%, Vehicle arm
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Rehan Ahmed
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