Clinical trials: Low Dose
Cerebrovascular Function, Cognition
Ketone Dose and Cerebral Blood Flow Study
Ketone bodies are produced by the liver during periods of food scarcity or severe carbohydrate restriction. Blood ketones are an alternative fuel source used by the brain, heart, and skeletal muscle during periods of fasting.
- Trial name
- kCBF (NCT06032156)
- Testing
- Low Dose β-OHB, High Dose β-OHB
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma
Efficacy of LAMA Added to ICS in Treatment of Asthma (ELITRA)
Primary objective The primary objective was to evaluate the superiority of CHF 5259 (glycopyrronium bromide [GB]) in a pressurised metered dose inhaler (pMDI) (50 μg total daily dose) versus placebo in terms of forced expiratory…
- Trial name
- ELITRA (NCT02296411)
- Testing
- CHF 5259 12.5 µg + Qvar
- Where
- 28 sites in Bulgaria, Germany and 3 more
- Volunteers
- 98 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Periodontitis, Type2 Diabetes
Effect of Aspirin Vs Omega 3 Fatty Acid After Scaling and Root Planing in Type II Diabetic Patients With Chronic Periodontitis
The main aim and objective of this study is to compare the effectiveness of low dose aspirin vs omega 3 fatty acids as adjuvants to non-surgical periodontal therapy and also to evaluate the levels of pentraxin 3 and glycosylated…
- Trial name
- EAOFASRPDMCP (NCT03599401)
- Testing
- Scaling and root planing
- Where
- India
- Volunteers
- 42 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Metastatic Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma
BATS With in Combination With Low Dose IL-1 and GM-CSF for Advanced Pancreatic Cancer
This phase Ib/II trial studies the side effects and best dose of bispecific antibody armed activated T-cells when given together with aldesleukin and sargramostim and to see how well they work in treating patients with pancreatic…
- Conditions
- Metastatic Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage III Pancreatic Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT02620865
- Testing
- Aldesleukin, Antibody Therapy, Fluorouracil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Pervasive Developmental Disorder
Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD)
This study will examine the effects of low-dose naltrexone (LDN) on children with autistic spectrum disorders. The investigators hope to show a positive effect on social functioning and language.
- Trial name
- NCT00318162
- Testing
- low dose naltrexone
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Dental Malocclusion
Effect of Low Level Laser on Orthodontic Canine Retraction
The aim of this study was to determine whether orthodontically moved maxillary canines exposed to two different protocols and dosage of LLLT exhibited differences in amount and rate of orthodontic tooth movement.
- Trial name
- NCT04381442
- Testing
- Low Level Laser Therapy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Rectal Cancer
Chemotherapy Combined With High-dose Radiotherapy for Low Rectal Cancer Using MR Guided Linear Accelerator
The incidence rate of colorectal cancer is third in male tumors and second in female tumors. The newly diagnosed incidence of colorectal cancer is no less than 100 thousand in China, which poses a great threat to people's health…
- Trial name
- NCT05338866
- Testing
- Magnetic resonance guided radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Sun Yat-sen University
Systemic Scleroderma
Low-Dose Conditioning Followed by Donor Stem Cell Transplant in Treating Patients With Severe Systemic Sclerosis
The purpose of the study is to see how well reduced intensity conditioning followed by a stem cell transplant from a donor (allogeneic) works in treating patients with severe systemic sclerosis.
- Trial name
- NCT01047072
- Testing
- fludarabine phosphate, total-body irradiation, tacrolimus
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Painful Diabetic Neuropathy
Low-Dose Naltrexone for the Treatment of Painful Diabetic Neuropathy
Diabetes affects more than 30 million people in the United States and is a leading cause of morbidity. Over 25% diabetics also suffer from debilitating painful diabetic neuropathy in the lower legs and feet.
- Trial name
- NCT04678895
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Abdomen, Acute, Other Acute Pain
Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department
The purpose of this study is to compare the safety and effectiveness of intravenous low dose ketamine (LDK) to the industry standard of morphine (MOR) in regards to controlling acute pain in the emergency department.
- Conditions
- Abdomen, Acute, Other Acute Pain, Flank Pain, Back Pain
- Trial name
- NCT01538745
- Testing
- Ketamine, Morphine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brooke Army Medical Center
Hip Fractures
Haemodynamic Effects of Low-dose Spinal Anaesthesia for Hip Fracture Surgery.
Approximately 65, 000 hip fractures occur in the United Kingdom (UK) each year, and more than 99% are repaired by surgery. Roughly half of patients receive spinal anaesthesia, where a small amount (usually less than half a…
- Trial name
- NCT05799300
- Testing
- Intrathecal anaesthesia
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Royal Sussex County Hospital
MDS, Myelodysplastic Syndromes
Determination of Safe and Effective Dose of Romiplostim (AMG 531) in Subjects With Myelodysplastic Syndrome (MDS)Receiving Hypomethylating Agents
The purpose of this study is to evaluate the effect of Romiplostim (AMG 531) on the incidence of clinically significant thrombocytopenic events (grade 3 or 4 and/or receipt of platelet transfusions) in subjects with low or…
- Conditions
- MDS, Myelodysplastic Syndromes, Thrombocytopenia
- Trial name
- NCT00321711
- Testing
- AMG 531 (Romiplostim), Azacitidine, Decitabine
- Volunteers
- 69 people
- Sponsor
- Amgen
Multiple Myeloma
Study of Initial Treatment With Elotuzumab, Carfilzomib, Lenalidomide and Dexamethasone in Multiple Myeloma
This study was a multi-center, open-label, single-arm, Phase 2 study where newly diagnosed Multiple Myeloma requiring systemic chemotherapy will be eligible for enrollment. A total of 46 subjects were enrolled.
- Trial name
- NCT02969837
- Testing
- Elotuzumab, Carfilzomib, Lenalidomide
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Chicago
Histologically Proven Diagnosis of Glioblastoma or Gliosarcoma (WHO Grade IV)
Phase II Trial of Low-Dose Whole Brain Radiotherapy With Concurrent Temozolomide and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma Multiforme
In the current proposed trial the role of the low-dose WBRT (0.15 Gy) would be to safely treat the microscopic distant GBM cells outside of the high dose RT region and sensitize the gross tumor, while the focal radiation dose…
- Trial name
- GCC 1224 (NCT01822275)
- Testing
- Chemotherapy with Temodar., Radiation therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Maryland, Baltimore
Idiopathic Thrombocytopenic Purpura, Anemia, Hemolytic, Autoimmune
Alemtuzumab and Rituximab in the Treatment of Refractory Autoimmune Cytopenias
The purpose of this study is to determine whether the combination of low doses of alemtuzumab and rituximab are effective in the treatment of patients with autoimmune cytopenias who has failed on steroids, relapsed after steroids…
- Trial name
- NCT00749112
- Testing
- Alemtuzumab, Rituximab
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Radiation Dose Reduction
Tin Filter Calcium Scoring
The aim of this study is to prospectively investigate the diagnostic performance and potential radiation dose reduction in coronary artery calcium scoring using the new tin filter system of the 3rd generation DSCT scanner.
- Trial name
- NCT02855528
- Testing
- Tin Filter
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Adult Spinal Deformity
Tranexamic Acid Dosing in Adult Spinal Deformity Surgery
The purpose of this study is to evaluate two dosing protocols for tranexamic acid (TXA), an anti-fibrinolytic used to decrease blood loss in adult patients undergoing complex, reconstructive spinal fusion surgeries.
- Trial name
- NCT02053363
- Testing
- Tranexamic Acid (Cyklokapron)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Washington University School of Medicine
HDL Cholesterol
Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)
Summary: Background: There is a lot of interest in the function and role of HDL to prevent and mitigate atherosclerosis in patients who are at or near LDLc targets.
- Trial name
- NCT00736463
- Testing
- Simvastatin, Atorvastatin 80 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma
Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer
This clinical trial studies fludarabine phosphate, low-dose total-body irradiation, and donor stem cell transplant followed by cyclosporine, mycophenolate mofetil, and donor lymphocyte infusion in treating patients with…
- Conditions
- Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma
- Trial name
- NCT00006251
- Testing
- total-body irradiation, fludarabine phosphate, cyclosporine
- Where
- 2 sites in United States, Italy
- Volunteers
- 21 people
- Sponsor
- Fred Hutchinson Cancer Center
Post-craniotomy, Pain
Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy
Post-craniotomy pain is common and often associated with poor outcomes. Flurbiprofen axetil (FA) is an injectable NSAID for postoperative analgesia, however, the impact of local FA, remains elusive on post-craniotomy pain.
- Trial name
- NCT07209345
- Testing
- FA+Ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Beijing Tiantan Hospital
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