Clinical trials: Low Ejection Fraction
Cardiac Revascularization
ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting
Coronary artery bypass graft (CABG) surgery can result in severe postoperative complications, such as renal and pulmonary failure.
- Trial name
- NCT04639856
- Testing
- Coronary Artery Bypass Grafting
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Institute of Cardiology, Pakistan
Heart Failure
Cardiac Rhythm Monitoring After Acute Decompensation for Heart Failure
The CARRYING ON for heart failure (HF) study is a national, prospective, post market interventional, multi-center, open-label, pilot trial.The purpose of the study is to assess a short term and a long term period, incidence of…
- Trial name
- CARRYINGON (NCT01216670)
- Testing
- remote patient's management
- Where
- 4 sites in Italy
- Volunteers
- 18 people
- Sponsor
- Medtronic Italia
Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a common and serious complication of obesity and type 2 diabetes (T2D). HFpEF occurs when the heart muscle unable to relax efficiently to pump the blood around the body.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
- Trial name
- AMEND (NCT05887271)
- Testing
- Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Leicester
Coronary Artery Bypass, Cardiopulmonary Bypass
Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF
Coronary artery disease has the highest mortality rate worldwide and coronary artery bypass grafting (CABG) is the most common cardiac surgery performed in patients with coronary artery disease to revascularize the heart.
- Conditions
- Coronary Artery Bypass, Cardiopulmonary Bypass, Coronary Artery Disease
- Trial name
- NCT04560309
- Testing
- L-alanyl-L-glutamine dipeptide
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Mitral Regurgitation, Heart Failure
MitraClip for the Treatment of Moderate Functional Mitral Regurgitation: EVOLVE-MR
This study evaluates the addition of transcatheter mitral valve repair with the MitraClip device to medical treatment in patients with heart failure and moderate functional mitral regurgitation to determine the impact of left…
- Conditions
- Mitral Regurgitation, Heart Failure, Mitral Valve Regurgitation Due to Cardiomyopathy (Disorder)
- Trial name
- EVOLVE-MR (NCT03705312)
- Testing
- Transcatheter mitral valve repair, Guideline-directed medical therapy
- Where
- Canada
- Volunteers
- 174 people
- Sponsor
- Montreal Heart Institute
Hemodynamic (MAP) Stability
Unilateral Spinal vs General Anaesthesia in Low EF Patients: A Hemodynamic Comparison
A difference exists in intraoperative hemodynamic stability and vasopressor requirement between the two techniques
- Trial name
- NCT07752303
- Testing
- Unilateral spinal anesthesia, General anesthesia
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Sargodha Medical College
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Chronic Heart Failure With Reduced Ejection Fraction
Effects of Repletion of Sodium Chloride on Natriuresis, Blood Pressure, and Neurohormonal Activity in Patients With Chronic Heart Failure With Reduced Ejection Fraction
The study is a single-center, prospective, randomized, placebo-controlled, double-blind trial conducted at the Institute of Heart Diseases and the Department of Cardiology of Wroclaw Medical University Hospital.
- Trial name
- RESALT-CHF (NCT07614295)
- Testing
- Sodium chloride supplementation
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Wroclaw Medical University
Heart Failure, Low T3 Syndrome
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)
Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
- Trial name
- LIHFA (NCT01481402)
- Testing
- Liothyronine
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Jens Faber
Heart Failure, Ventricular Dysfunction, Left
ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era
Asymptomatic left ventricular systolic dysfunction (ALVSD), identified as a key component of stage B heart failure (HF) by AHA/ACC guidelines, is a common precursor to clinically overt HF.
- Conditions
- Heart Failure, Ventricular Dysfunction, Left, Artificial Intelligence, Early Diagnosis
- Trial name
- ELEGANT (NCT06968533)
- Testing
- AI-ECG guided diagnosis
- Where
- Taiwan
- Volunteers
- 13,350 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Low Ejection Fraction Patients, Fracture Tibia
Unilateral Epidural Block Versus Ultrasound Guided Combined Femoro-sciatic Nerves Block for Patients With Low Ejection Fraction
compare unilateral epidural anesthesia versus femoral/sciatic nerve block by ultrasound guided as anesthetic technique for cases with low ejection fraction undergoing insertion of nail tibia for fixation of fracture shaft tibia.
- Trial name
- NCT05506501
- Testing
- unilateral epidural anesthesia, Ultrasound guided femoro/ sciatic nerve block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Left Ventricular Systolic Dysfunction (Disorder)
Artificial Intelligence-assisted Diagnosis and Prognostication in Low Ejection Fraction Using Electrocardiograms
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- NCT05117970
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- Taiwan
- Volunteers
- 13,631 people
- Sponsor
- National Defense Medical Center, Taiwan
Hypertension, Pulmonary, Heart Failure With Reduced Ejection Fraction
Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG
This is a prospective, observational study evaluating whether heart sounds (phonocardiograms) and three-lead electrocardiograms (ECGs) recorded using the Eko CORE 500 digital stethoscope can help detect pulmonary hypertension…
- Trial name
- PH ELEFT 2-0 (NCT07087613)
- Testing
- Eko CORE 500 Digital Stethoscope
- Where
- 4 sites in United States
- Volunteers
- 3,850 people
- Sponsor
- Eko Devices, Inc.
Cardiac Surgery, Low Ejection Fraction
Impact of Perioperative Levosimendan on Patients Undergoing Cardiac Surgery With Low Ejection Fraction
to compar levosemindan to other cardiac intropic medications that strengthen the heart in diffrent common adult heart surgery with patients with low ejection fraction(weak heart)
- Trial name
- NCT06784570
- Testing
- levosemindan, adrenaline,noreadrenaline,dopamine and doputamine
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Zagazig University
Myocardial Ischemia, Congestive Heart Failure
Stem Cell Study for Patients With Heart Failure
The purpose of this study is to determine if cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will improve your ejection fraction…
- Conditions
- Myocardial Ischemia, Congestive Heart Failure, Cardiovascular Disease
- Trial name
- NCT00346177
- Testing
- Autologous Stem Cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Losordo, Douglas, M.D.
Impaired Left Ventricular Ejection Fraction
Validation of Kinocardiography, New Technology for Cardiac Linear and Torsional Contractility Measurement, to Assess Heart Failure Patient With Low Ejection Fraction
Measuring cardiac contractility is commonly realized with gold standard echocardiography or MRI. Portable devices to measure this contractility are not available as for rhythm and electric function assessment.
- Trial name
- NCT03157115
- Testing
- Kinocardiography
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Brugmann University Hospital
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
ST Elevation Myocardial Infarction
The Effect of Low-Level Tragus Stimulation on Echocardiographic Parameters in Patients With ST-Segment Elevation Myocardial Infarction - A Single-Centre Randomized Control Trial
The goal of this clinical trial is to learn the effect of low level tragus stimulation (LLTS) on echocardiographic parameter in patient with ST-segment Elevation Myocardial Infarction (STEMI) who undergo primart percutaneous…
- Trial name
- ELITE-STEMI (NCT07058857)
- Testing
- Parasym Neuromodulation Device (Treatment Group)
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Diponegoro
Left Ventricular Dysfunction, Ventricular Dysfunction
Low Ejection Fraction in Single Lead ECG
The purpose of this research is to prospectively test and validate the single-lead Low EF algorithm in outpatients in order to test the performance of a single-lead ECG based algorithm to identify people with decreased left…
- Conditions
- Left Ventricular Dysfunction, Ventricular Dysfunction, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT05010655
- Testing
- Use of Eko DUO Electronic Stethoscope
- Where
- 2 sites in United States
- Volunteers
- 1,935 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Coronary Artery Bypass Grafting, Left Ventricular Dysfonction
Preoperative Levosimendan in CABG Patients With Poor LV Function
The investigators want to test the hypothesis that an infusion of levosimendan started prior to CABG surgery can reduce incidence and severity of low cardiac output syndrome in patients with poor LV function (EF 40% or less).
- Trial name
- LICORN (NCT02184819)
- Testing
- levosimendan
- Where
- France
- Volunteers
- 335 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris